Diffuse Large B-Cell Lymphoma of the Left Upper Extremity Mimicking a Sarcoma

Siddiqui, Raheel S; Ferman, Debra; Tuli, Sandeep; Kemeny, Margaret

doi:10.7759/cureus.15588

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin lymphoma originating from the germinal center and it represents a heterogeneous group of diseases with variable outcomes: it is ideally diagnosed from an excisional biopsy of a suspicious lymph node [1]. DLBCL is extremely uncommon in the soft tissue of the upper extremity and a few cases have been reported in the literature, where they were initially mistaken to be other tumor, like sarcomas [2]. Ultrasonography could be considered the best method to evaluate lymph nodes and soft tissue in the suspect of lymphoproliferative disease, due to its high speci city and accurancy in the study and characterization of normal and pathological aspects [3].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound of Non-Hodgkin Lymphoma Involving Soft Tissue of the Arm: a case report.

Ciampi¹,

Petrelli²

2023

Preprint

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An 80-year-old woman presented to the hospital with a 11-month history of swelling that progressively involved the whole left upper limb. Her clinical history was rilevant for arterial hypertension, obesity and rheumatoid arthritis. Ultrasonography revealed hypoechoic nodules in soft tissue of the left arm,brachial vein thrombosisandmalignant left axillary lymphadenopathy. The patient started antithrombotic therapy and underwent axillary lymph nodes excisional biopsy: a diagnosis of diffuse large B-cell lymphoma was made and she was referred to hematology clinic for chemotherapy. At a 3-month follow-up visit, the patient showed decrease of the swelling of her upper limb; the ultrasonographic control demonstrated reduction in size and number of soft tissue nodules and resolution of vein thrombosis.

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Section: Discussionmentioning

confidence: 99%

Ultrasound of Non-Hodgkin Lymphoma Involving Soft Tissue of the Arm: a case report.

Ciampi¹,

Petrelli²

2023

Preprint

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“…1 Few cases involving both upper and lower extremities have been reported in the literature, where they were initially thought to be sarcomas and ultimately diagnosed as non hodgkin's lymphoma after excision biopsy. 2 Bolke et al 5 Further research on this domain may have immense impact on the therapeutic modalities of these patients. Our case signifies the importance of including lymphoma in differential diagnosis of sarcoma of extremities.…”

Section: Discussionmentioning

confidence: 99%

“…1 The primary site for DLBCL is lymph node, however extra nodal involvement has been seen in many cases with gastrointestinal tract is the most common site. 2 Other sites are skin, soft tissue, bone, central nervous system and genitourinary system. It affects all ages but incidence is higher in elderly people around sixth to seventh decade of life.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic surprise on IHC: A rare case of intramuscular DLBCL in thigh region mimicking sarcoma

Agrawal¹,

Ansari

Bhamra³

2022

ACHR

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Soft tissue sarcomas are broad group of malignant tumours that arise in tissues like fat, muscle, nerves, fibrous tissue and blood vessels. A variety of non mesenchymal neoplasms like sarcomatoid carcinomas, melanomas and extranodal lymphomas may also mimic soft tissue sarcoma. Diffuse Large BCell Lymphoma is the most common type of Non HodgkinsLymphoma accounting for around 30-40% of cases.DLBCL involving skeletal muscle is extremely rare accounting approximately <1% of the cases with most of the cases reported in the lower extremity involving calf and thigh region.Here we report a case of DLBCL of the left thigh mass in 60 years old male which was initially thought to be a sarcoma based on clinical findings and imaging, but was later diagnosed to be DLBCL after surgical excision of the mass with the help of histopathology and immunohistochemistry.

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“…All these were clinically suspected to be sarcomas and most cases involved the extremities. 8,9,10 Uncommon sites include back, abdominal wall, pelvis and gluteal region. 7 Our case is a primary skeletal muscle lymphoma presenting at the lumbar region of the back (which is an unusual site).…”

Section: 7mentioning

confidence: 99%

Primary Skeletal Muscle Diffuse Large B Cell Lymphoma in Lumbar Region – A Rare Occurrence

Muralidhar,

Mahadev,

Minal

et al. 2024

Int. J. Hum. Health Sci.

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Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma worldwide. Patients most often present with a rapidly growing tumour mass in single or multiple, nodal, or extranodal sites. Extranodal involvement is seen in up to 40% cases. Initial presentation as soft tissue lesion is rare. We report a case of extranodal DLBCL in an elderly male, presenting as a soft tissue mass in the left lumbar region, clinically suggestive of lipoma. The patient had no palpable lymphadenopathy. Complete blood counts were within normal limits. Initial ultrasonography was suggestive of abscess, possibly of tubercular origin. On fine needle aspiration cytology, features were of a malignant neoplasm; a lymphomatous process. Subsequent histopathological evaluation followed by IHC confirmed the diagnosis of DLBCL. Primary extranodal DLBCL involving the soft tissue is rare. Owing to its non- specific and unusual clinical presentation, accurate diagnosis may be delayed. Besides, imaging modalities are also diagnostically challenging due to a wide range of differentials, thereby emphasising the need for tissue diagnosis. Histopathological examination and immunohistochemistry are paramount in accurate diagnosis and tailoring treatment options.International Journal of Human and Health Sciences Vol. 08 No. 01 Jan’24 Page: 95-98

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Diffuse Large B-Cell Lymphoma of the Left Upper Extremity Mimicking a Sarcoma

Cited by 4 publications

References 10 publications

Ultrasound of Non-Hodgkin Lymphoma Involving Soft Tissue of the Arm: a case report.

Ultrasound of Non-Hodgkin Lymphoma Involving Soft Tissue of the Arm: a case report.

Diagnostic surprise on IHC: A rare case of intramuscular DLBCL in thigh region mimicking sarcoma

Primary Skeletal Muscle Diffuse Large B Cell Lymphoma in Lumbar Region – A Rare Occurrence

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