Diffuse interstitial leukemic infiltration of the lungs producing the alveolar-capillary block syndrome

Resnick, Myron E.; Berkowitz, Richard; Rodman, Theodore

doi:10.1016/0002-9343(61)90232-7

Cited by 31 publications

(3 citation statements)

References 8 publications

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“…This relationship could result from lymphocyte infiltration of lung parenchyma or pleura, as reported in autopsy series (15,29,31). A massive lymphocytic infiltration of the lung has been reported to cause restrictive respiratory failure, with severe decrease in alveolar capillary lung diffusion [16][17][18][19][20][21][22][23][24][25][26][27]. Our series did not include cases with hyperleucocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…The few existing studies are limited to case reports of "alveolar-capillary block syndrome" in patients with hyperleukocytosis [16][17][18][19][20][21][22][23][24][25][26][27]. In the present work we have evaluated respiratory function tests, including lung volumes, diffusing capacity, and bronchial responsiveness to methacholine, in a group of 24 outpatients with B-CLL in different stages of their disease.…”

Section: Introductionmentioning

confidence: 99%

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Respiratory symptoms, lung function tests, airway responsiveness, and bronchoalveolar lymphocyte subsets in B-Chronic lymphocytic leukemia

Rolla

Bucca

Chiampo

et al. 1993

Lung

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A respiratory questionnaire was completed and spirometry, tests for lung volumes, diffusion capacity for CO, and methacholine bronchial challenge were performed in 24 outpatients with B-chronic lymphocytic leukemia (B-CLL), aged 44-79, presenting in different stages of their disease. In 10 patients, bronchoalveolar lavage (BAL) fluid was also obtained. Ten of twenty-four patients had symptoms consistent with chronic bronchitis, unrelated both to smoking history and to the clinical stage. Abnormal values (< 2 SD) were found in 4 patients for total lung capacity (TLC), in 9 for vital capacity (VC), 8 for forced expiratory volume in 1 sec (FEV1), 11 for MEF50, 15 for MEF25 and in 7 for diffusing capacity for carbon monoxide. Seven of nineteen patients had PD20FEV1 at less than 1,600 micrograms of methacholine chloride. There was a significantly negative correlation between white blood cell count and VC (r = 0.41, P < 0.05). A positive correlation was found between PD20FEV1 and FEV1/VC (r = 0.61, P < 0.01). The mean and SEM for BAL cells/ml was 463 (71.8) x 10(3). No leukemic cells but a marked increase in T lymphocytes (32.5 +/- 7.8%) were found in BAL fluid. There were significantly negative correlations between the number of BAL CD3+ T lymphocytes and PD20FEV1 (r = 0.61, P < 0.05), and between the number of BAL CD8+ T lymphocytes and PD20FEV1 (r = 0.84, P < 0.01). In conclusion, patients with B-CLL have a high prevalence of respiratory symptoms, small airway dysfunction and CD8 "alveolitis" related to airway responsiveness; despite the well-known lung interstitial lymphocyte infiltration in B-CLL, leukemic cells are not found in BAL fluid.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Respiratory symptoms, lung function tests, airway responsiveness, and bronchoalveolar lymphocyte subsets in B-Chronic lymphocytic leukemia

Rolla

Bucca

Chiampo

et al. 1993

Lung

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“…All but one of these patients were affected by AML with the leucocyte count between 12 and 200 leucocytes · 10 9 /l. In all these patients, the leukaemic pulmonary infiltrates were strongly related to a high proportion of blast cells, with a peripheral blast count > 40% (Resnick et al, 1961;Geller, 1971;Prakash et al, 1979;Nelson & Ravreby, 1980;Kovalski et al, 1990). Six children have been also reported, five with acute lymphocytic leukaemia and one with acute monocytic leukaemia, with dyspnoea, radiographic pulmonary infiltrates and biopsy-proven alveolar septal or nodular leukaemic infiltrates.…”

mentioning

confidence: 92%

Leukaemic pulmonary infiltrates in adult acute myeloid leukaemia: a high‐resolution computerized tomography study

Potenza¹,

Luppi²,

Morselli³

et al. 2003

Br J Haematol

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Leukaemic infiltration of the lungs may occur in acute myeloid leukaemia (AML). Pulmonary infiltrates are usually microscopic and invariably associated with hyperleucocytosis. Four AML patients with respiratory symptoms and low leucocyte counts underwent standard chest radiography, bronchoscopy with bronchoalveolar lavage and high-resolution computerized tomography (HRCT) of the lungs. HRCT scans showed pulmonary infiltrates with alveolar, interstitial, mixed and peribronchial/perivascular patterns in all patients, including one with negative standard radiographic findings. Infectious agents were excluded. Histology of the lung biopsy/autopsy specimens showed leukaemic infiltrates. Pulmonary leukaemia may be the cause of pulmonary infiltrates, even in non-hyperleucocytosic AML patients with low blast counts

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Respiratory Distress Secondary to Pulmonary Leukemia

Kelleher¹,

Miale²,

Donnelly³

1981

Arch Pediatr Adolesc Med

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Diffuse interstitial leukemic infiltration of the lungs producing the alveolar-capillary block syndrome

Cited by 31 publications

References 8 publications

Respiratory symptoms, lung function tests, airway responsiveness, and bronchoalveolar lymphocyte subsets in B-Chronic lymphocytic leukemia

Respiratory symptoms, lung function tests, airway responsiveness, and bronchoalveolar lymphocyte subsets in B-Chronic lymphocytic leukemia

Leukaemic pulmonary infiltrates in adult acute myeloid leukaemia: a high‐resolution computerized tomography study

Respiratory Distress Secondary to Pulmonary Leukemia

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