Diffuse Idiopathic Skeletal Hyperostosis: Can We Identify a Peripheral Pattern?

Clavaguera, Teresa; Reyner, Patrícia; Valls, Ramón; Cendra, E. De; Rodríguez-Jimeno, Mari Carmen

doi:10.1016/j.reumae.2017.03.013

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…3 Actualmente se diagnostica en estadios avanzados o cuando se presentan complicaciones graves. 11 En este caso, la paciente presento síntomas desde el año 1982 y fue diagnosticada 37 años después de manera accidental.…”

Section: Discussionunclassified

Síndrome de Forestier: caso clínico y revisión de la literatura

Palma

Molina²

2021

Rev Méd Hondur

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Antecedentes: El síndrome de Forestier también conocido como Hiperostosis Esquelética Idiopática Difusa (DISH, por sus siglas en inglés), es una enfermedad de etiología desconocida que se caracteriza por osificación del ligamento espinal anterior, siendo las porciones cervicales y torácicas las que se afectan más frecuentemente. Esta enfermedad es más frecuente en hombres y se asocia con diabetes, hipertensión arterial, dislipidemia y trastornos endocrinos. Descripción del caso clínico: Paciente femenina de 63 años con antecedente de dolor cervical desde hace 32 años, que 6 años después del inicio del cuadro, presentó limitación en la movilidad del cuello; presentando varios episodios de disfonía desde hace 10 años; al momento de la consulta la paciente presentó limitación de la movilidad del cuello y dolor cervical. La imagen de resonancia magnética reportó: presencia de crecimiento óseo anterior de los cuerpos vertebrales, este hallazgo está en relación con el síndrome de Forestier. Conclusiones: Por ser una enfermedad poco conocida es subdiagnosticada y a menudo confundida con otras patologías. Los pacientes son diagnosticados muchos años después de que aparecieron los primeros síntomas que incluyen dolor, limitación de la movilidad, disfagia y dificultad respiratoria. El tratamiento incluye manejo sintomático, terapia física y manejo quirúrgico.

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Section: Discussionunclassified

Síndrome de Forestier: caso clínico y revisión de la literatura

Palma

Molina²

2021

Rev Méd Hondur

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“…In a previous study, we reported three patients with an extensive ossification of entheses who did not fulfil the Resnick criteria, but who were indisputably affected by hyperostosis. We noted a distinct phenotype with predominant extraspinal manifestations, female predominance and earlier disease onset [ 5 ]. Recently, some authors have suggested that peripheral manifestations, such as hip involvement, could be prominent in DISH and lead to significant discapacity or functional impairment [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Identifying Clinicoradiological Phenotypes in Diffuse Idiopathic Skeletal Hyperostosis: A Cross-Sectional Study

et al. 2021

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Background and objectives: Diffuse idiopathic skeletal hyperostosis (DISH) is a bone formation disease in which only skeletal signs are considered in classification criteria. The aim of the study was to describe different phenotypes in DISH patients based on clinicoradiological features. Materials and Methods: We evaluated 97 patients who met the Resnick or modified Utsinger classification criteria for DISH and were diagnosed at our hospital from 2004 to 2015. Patients were stratified into: (a) peripheral pattern (PP)—Resnick criteria not met but presenting ≥3 peripheral enthesopathies; (b) axial pattern (AP)—Resnick criteria met but <3 enthesopathies; and (c) mixed pattern (MP)—Resnick criteria met with ≥3 enthesopathies. Statistical analysis was carried out to identify variables that might predict classification in a given group. Results: Fifty-six of the 97 patients included (57.7%) were male and 72.2% fulfilled the Resnick criteria. Applying our classification, 39.7% were stratified as MP, 30.9% as AP and 29.4% as PP. Clinical enthesopathy was reported in 40.2% of patients during the course of the disease. Sixty-eight patients were included in a comparative analysis of variables between DISH patterns. The results showed a predominance of women (p < 0.004), early onset (p < 0.03), hip involvement (p < 0.003) and enthesitis (p < 0.001) as hallmarks of PP. Asymptomatic patients were most frequently observed in AP (28.6%, MP 3.8%, PP 5.0%) while MP was characterized by a more extensive disease. Conclusions: We believe DISH has distinct phenotypes and describe a PP phenotype that is not usually considered. Extravertebral manifestations should be included in the new classification criteria in order to cover the entire spectrum of the disease.

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Diffuse Idiopathic Skeletal Hyperostosis: Can We Identify a Peripheral Pattern?

Cited by 2 publications

References 12 publications

Síndrome de Forestier: caso clínico y revisión de la literatura

Síndrome de Forestier: caso clínico y revisión de la literatura

Identifying Clinicoradiological Phenotypes in Diffuse Idiopathic Skeletal Hyperostosis: A Cross-Sectional Study

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