Diffuse Gallbladder Wall Thickening on Computed Tomography in Patients With Liver Cirrhosis

Son, Jee Young; Kim, Young Jun; Park, Hee Sun; Yu, Nam C.; Ko, Sung Min; Jung, Sung Il; Jeon, Hae Jeong

doi:10.1097/rct.0b013e31822d2ade

Cited by 11 publications

(7 citation statements)

References 14 publications

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“…The latter fact is in contrast to different studies which described a significant correlation between hypalbuminemia and pathologically increased GBWT. 3,9,17 However, most of the patients in these studies also had advanced cirrhosis, so that ACLD appears to be the main factor here and hypalbuminemia is to be seen as a bystanding phenomenon. This assumption is supported by the studies of Colli et al and Kaftori et al who were able to show that there is no gallbladder wall thickening in patients with ascites and hypalbuminemia in the absence of ACLD.…”

Section: Discussionmentioning

confidence: 93%

“…Diffuse gallbladder wall thickening in the absence of gallbladder disease is a common finding on imaging. Reported causes include advanced chronic liver disease (ACLD), portal hypertension, ascites, and hypalbuminemia, which were postulated in various studies as independent driver 1–9 . Diffuse gallbladder wall thickening must be distinguished from focal or irregular wall thickenings, which can be associated with gallbladder carcinoma, polyps, or chronic cholezystitis 2,10 …”

Section: Introductionmentioning

confidence: 99%

“…Reported causes include advanced chronic liver disease (ACLD), portal hypertension, ascites, and hypalbuminemia, which were postulated in various studies as independent driver. [1][2][3][4][5][6][7][8][9] Diffuse gallbladder wall thickening must be distinguished from focal or irregular wall thickenings, which can be associated with gallbladder carcinoma, polyps, or chronic cholezystitis. 2,10 Recently, we showed a positive correlation between the gallbladder wall thickness (GBWT) and the presence of esophageal varices (EV) in patients with chronic liver disease.…”

Section: Introductionmentioning

confidence: 99%

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Pathological gallbladder wall thickening is associated with advanced chronic liver disease and independent of serum albumin

Bremer

Knoop

Porsche

et al. 2021

J of Clinical Ultrasound

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Purpose Increased gallbladder wall thickness (GBWT) is a common finding. Reported causes include advanced chronic liver disease (ACLD), ascites and hypalbuminemia. GBWT is a marker for the prediction of esophageal varices. It remains unclear which of these factors is the decisive driver of GBWT. We aim to investigate whether there is a predominant factor associated with the GBWT. Methods We enrolled 258 patients with ascites, hypalbuminemia and/or ACLD and 98 healthy volunteers that underwent abdominal ultrasound. Differences of mean GBWT in subgroups of patients with ACLD, ascites, and/or hypalbuminemia were analyzed. Correlation between various parameters and GBWT were calculated using multiple regression analysis. Results GBWT in patients with ACLD + ascites + hypalbuminemia (n = 59; 5.70 ± 2.05 mm) was pathologically increased compared to patients with hypalbuminemia + ascites without ACLD (n = 36; 2.14 ± 0.66 mm; p < .001) and to patients with only hypalbuminemia (n = 76; 2.02 ± 0.80 mm; p < .001). GBWT of patients with ACLD + hypalbuminemia (n = 30; 3.42 ± 1.52 mm) and with ACLD and normal albumin level were not different (n = 46; 3.10 ± 1.62 mm; p > .999). Significant correlation was seen between GBWT and ACLD (r = .53; p < .001) and ascites (r = .51; p < .001) but not albumin level (r = .04; p = .510). Conclusion We demonstrate that ACLD is predominantly associated with GBWT. In contrast to the current literature, serum albumin level appears not to be associated with pathological GBWT.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pathological gallbladder wall thickening is associated with advanced chronic liver disease and independent of serum albumin

Bremer

Knoop

Porsche

et al. 2021

J of Clinical Ultrasound

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“…In addition to the above, the disorder of gallbladder contractility in patients with liver cirrhosis also influenced by humoral changes. [13][14][15][16][17] Humoral changes that occur in liver cirrhosis are due to cholecystokinin (CCK) receptor resistance in the gallbladder. Thus, the contraction of the gallbladder disrupted.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study Gallbladder Contractility Index Using Ultrasound in Patients with and without Liver Cirrhosis

Soekersi

Santiana

Fatmawaty

2020

GMHC

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Liver cirrhosis leads to impairment of gallbladder contractility resulting in bile stasis and facilitate the development of gallstones that will aggravate the clinical symptoms of the patients. The gallbladder contractility index is an indicator of gallbladder motility measured using ultrasound as the radiological choice of modality. This study aims to determine differences in the gallbladder contractility index using ultrasound in patients with and without liver cirrhosis. This study was an observational study of comparative analytic with cross-sectional design with sampling conducted by consecutive admissions sampling at Dr. Hasan Sadikin General Hospital Bandung from December 2017 to February 2018. Statistical analysis than performed by using an independent t test to find out the difference of gallbladder contractility index in patients with and without liver cirrhosis. A total of 22 subjects, 12 men, 10 women, with the youngest 37 years old and the oldest 70 years old. The result of the study was obtained mean fasting gallbladder volume (35.56±22.16 mL) and postprandial (21.25±16.08 mL) in patients with liver cirrhosis higher than without liver cirrhosis with mean fasting gallbladder volume (16.50±4.14 mL) and postprandial (5.44±2.10 mL). The average gallbladder contractility index on patients with liver cirrhosis (41.64±24.52%) smaller than without liver cirrhosis (66.73±9.19%). The result of the statistical test showed that there was a significant difference in the gallbladder contractility index on patients with liver cirrhosis than without liver cirrhosis (p=0.007, p≤0.05). In conclusion, there was a significant difference in the gallbladder contractility index that measured by using ultrasound between the patients with and without liver cirrhosis. PERBEDAAN INDEKS KONTRAKTILITAS KANDUNG EMPEDU MENGGUNAKAN ULTRASONOGRAFI PADA PENDERITA SIROSIS HATI DAN TANPA SIROSIS HATISirosis hati menyebabkan gangguan indeks kontraktilitas kandung empedu yang mengakibatkan stasis cairan empedu dan memudahkan kejadian batu empedu yang akan memperberat gejala klinis pasien. Indeks kontraktilitas kandung empedu merupakan indikator motilitas kandung empedu yang diukur menggunakan ultrasonografi (USG) sebagai modalitas pilihan radiologi. Penelitian ini bertujuan mengetahui perbedaan indeks kontraktilitas kandung empedu menggunakan ultrasonografi pada pasien sirosis hati dan tanpa sirosis. Penelitian ini menggunakan studi observasional analitik komparatif dengan rancangan cross-sectional dan pengambilan sampel dilakukan secara consecutive admissions sampling di RSUP Dr. Hasan Sadikin Bandung dari bulan Desember 2017 hingga Februari 2018. Uji statistik menggunakan independent t test. Subjek penelitian berjumlah 22, laki-laki 12 dan perempuan 10, serta usia termuda 37 tahun dan tertua 70 tahun. Hasil penelitian didapatkan volume rerata kandung empedu puasa (35,56±22,16 mL) dan pascaprandial (21,25±16,08 mL) pada pasien sirosis hati lebih besar daripada tanpa sirosis hati dengan volume rerata kandung empedu puasa (16,50±4,14 mL) dan pascaprandial (5,44±2,10 mL). Indeks kontraktilitas rerata kandung empedu penderita sirosis hati (41,64±24,52%) lebih rendah dibanding dengan tanpa sirosis hati (66,73±9,19%). Hasil uji statistik menunjukkan terdapat perbedaan bermakna antara indeks kontraktilitas kandung empedu penderita sirosis hati dan tanpa sirosis hati (p=0,007; p≤0,05). Simpulan, terdapat perbedaan bermakna antara indeks kontraktilitas kandung empedu menggunakan USG pada penderita sirosis hati dan tanpa sirosis hati.

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“…The presence of diffuse GB wall thickening in cirrhotic patients is associated with clinical/laboratory variables (21). A prospective study involving more patients is warranted to correlate the extrarenal manifestations with the severity of the illness.…”

Section: Patientsmentioning

confidence: 99%

Gallbladder Wall Thickening and Periportal Tracking on CT in Patients with Acute Pyelonephritis

Shin

Sung

Park

et al. 2012

J Korean Soc Radiol

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Purpose:To assess gallbladder (GB) wall thickening and periportal tracking on CT in patients with acute pyelonephritis (APN) by each kidney involvement. Materials and Methods: A total of 117 patients diagnosed with APN by clinical examination and CT were included in this retrospective study. The patients were divided into three groups based on kidney involvement seen on CT: right APN, left APN, and bilateral APN. Two radiologists reviewed CT images in consensus for the presence of diffuse GB wall thickening and periportal tracking. The prevalence of these two manifestations was compared among the three groups. Results: The prevalence of GB wall thickening in patients with right APN (26.4%) and bilateral APN (19%) was significantly higher than in patients with left APN (0%) (p < 0.016). The prevalence of periportal tracking in patients with right APN (15.1%) and bilateral APN (26%) was higher than in patients with left APN (3%), with a significant difference between patients with bilateral APN and left APN (p < 0.016). Conclusion: GB wall thickening and periportal tracking are predominantly encountered on CT in patients with APN involving the right kidney (right and bilateral APN), and should be considered in differential diagnosis of diseases associated with GB wall thickening and periportal tracking.

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Diffuse Gallbladder Wall Thickening on Computed Tomography in Patients With Liver Cirrhosis

Abstract: The presence of DGWT in cirrhotic patients is associated with the presence of ascites, lower platelet count, and lower albumin level. The degree of DGWT is not correlated with such variables.

Cited by 11 publications

References 14 publications

Pathological gallbladder wall thickening is associated with advanced chronic liver disease and independent of serum albumin

Pathological gallbladder wall thickening is associated with advanced chronic liver disease and independent of serum albumin

Comparative Study Gallbladder Contractility Index Using Ultrasound in Patients with and without Liver Cirrhosis

Gallbladder Wall Thickening and Periportal Tracking on CT in Patients with Acute Pyelonephritis

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