Diffuse follicle center lymphoma of the spine: a primary epidural lymphoma?

Fb, Mesfin; Drazin, Doniel; Berry, Shauna; Homan, Suzanne M.; Jw, German

doi:10.5414/npp28395

Cited by 7 publications

(23 citation statements)

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“…Patients clinically present most commonly in the fifth to seventh decade of life[15–18] with more than 80% being older than 40 years. [114–1619] Pediatric patients with PSEL, however, have also been reported. [520–23]…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…This has been attributed to both the greater length of the thoracic spine (compared with the cervical and lumbar) and to an enhanced ability to accommodate bulky disease in the thorax and abdomen. [1131416–1825] The rich venous plexus in the thoracic spine may be the reason for frequent occurrence of lymphomas in this site. [21]…”

Section: Locationmentioning

confidence: 99%

“…[243] In the report by Mesfin et al and Iizuka et al , a lesion in the epidural space that was in continuity with the vertebral foramina was identified. [144]…”

Section: Pathogenesismentioning

confidence: 99%

“…These are followed by lymphoma, plasmacytoma, multiple myeloma, and prostate malignancies. [1] Epidural lymphomas form 9% of all the spinal epidural tumors. An epidural location for lymphoma is observed in 0.1–6.5% of all the lymphomas.…”

Section: Introductionmentioning

confidence: 99%

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Primary spinal epidural lymphomas

Cugati

Singh

Pande

et al. 2011

J Craniovert Jun Spine

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An epidural location for lymphoma is observed in 0.1–6.5% of all the lymphomas. Primary spinal epidural lymphoma (PSEL) is a subset of lymphomas, where there are no other recognizable sites of lymphomas at the time of diagnosis. The incidence of this subset of lymphomas is much less. It, however, is increasingly diagnosed, due to the increased use of more sensitive imaging modalities. For the electronic search, Pubmed was used to identify journals that enlisted and enumerated PSEL from 1961 to January 2011. The following combination of terms: “primary,” “spinal,” “epidural,” and “lymphoma” were used. The most significant articles and their bibliographies were analyzed by the authors. The symptoms, pathogenesis, diagnostic workup, histopathology, treatment, and outcome have been analyzed in a systematic manner

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Section: Patient Characteristicsmentioning

confidence: 99%

Section: Locationmentioning

confidence: 99%

“…[243] In the report by Mesfin et al and Iizuka et al , a lesion in the epidural space that was in continuity with the vertebral foramina was identified. [144]…”

Section: Pathogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Primary spinal epidural lymphomas

Cugati

Singh

Pande

et al. 2011

J Craniovert Jun Spine

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“…In cases of primary disease presenting with spinal cord compression, surgical debulking is mandated and also allows for adequate tissue sampling for diagnosis [19]. This is followed by radiation therapy alone or in conjunction with chemotherapy but rarely with chemotherapy alone [19,28,29]. Rathmell et al reported a 33% actuarial survival rate in patients treated with radiation alone compared to 86% with combination therapy [30], while Monnard et al found that combined treatment was statistically superior to radiotherapy alone [19].…”

Section: Introductionmentioning

confidence: 99%

Primary epidural lymphocyte-depleted Hodgkin’s lymphoma of the thoracic spine – presentation of a rare disease variant

et al. 2012

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BackgroundLymphocyte-depleted Hodgkin’s lymphoma is the rarest form of classical Hodgkin’s lymphoma, accounting for < 1% of all cases. Patients often have advanced-stage disease at the time of presentation with an aggressive clinical course. Even more uncommon is primary extranodal disease and rarely it will be presenting with spinal cord compression.Case presentationAn 88-year-old Caucasian female presented with a history of upper back pain for several months and new onset bilateral leg numbness and weakness. MRI of the spine showed a dorsal epidural lesion with cord compression at T1-T4 with involvement of the paraspinal muscles. The patient received urgent surgical decompression, with final histopathology showing a lymphocyte-depleted Hodgkin’s lymphoma. Systemic work-up did not show evidence of nodal disease. Following surgery, she received a course of radiotherapy with good outcome.ConclusionTo the best of our knowledge, this is the first reported case of primary lymphocyte-depleted Hodgkin lymphoma presenting as epidural spinal cord compression. Our report, in conjunction with a review of the literature, suggests that surgical intervention is clearly indicated in de novo disease followed by radiotherapy.

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