Diffuse Esophageal Squamous Papillomatosis Covering the Entire Esophagus

Gençdal, Genco; Değirmencioğlu, Şerife; Akyıldız, Murat

doi:10.1016/j.cgh.2017.09.020

Cited by 9 publications

(6 citation statements)

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“…Esophageal squamous papillomatosis (ESP) is a rare condition characterized by well‐defined and exophytic circumferential projections, with friable mucosa diffusely spread through the esophagus. The incidence of singular or limited squamous esophageal papillomas is proposed to be between 0.01% and 0.04% of the population, 1,2 while diffuse ESP is exceedingly rare with only 17 cases reported to our knowledge 3–19 …”

Section: Introductionmentioning

confidence: 91%

Gastrointestinal: Distal esophageal squamous papillomatosis in a healthy 47‐year‐old man

Singh,

Brooks

2023

JGH Open

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A 47‐year‐old man with a background history of gastroesophageal reflux disease (GERD) and seasonal asthma underwent a gastroscopy for further investigation. Endoscopy revealed numerous polypoid lesions diffusely distributed in the lower third of the esophagus, with histology revealing squamous papilloma with occasional intraepithelial lymphocytes. The diagnosis was esophageal squamous papillomatosis (ESP), which is a rare condition characterized by exophytic and circumferential projections with friable mucosa diffusely spread through the esophagus with unclear etiology and malignancy risk.

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Section: Introductionmentioning

confidence: 91%

Gastrointestinal: Distal esophageal squamous papillomatosis in a healthy 47‐year‐old man

Singh,

Brooks

2023

JGH Open

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“…The cocktail for high-risk HPV (BOND RNA Scope HPV-High Risk 18 PROBE [ACD BIO 312598]) recognizes E6/E7 mRNA of 18 different subtypes including HPV 16,18,26,31,33,35,39,45,51,52,53,56,58,59, 66, 68, 73, and 82. The cocktail for low-risk HPV (BOND RNA Scope HPV-Low Risk 10 PROBE [ACD BIO 314558]) recognizes E6/E7 mRNA of 10 different subtypes including HPV 6,11,40,43,44,54,69,70,71,and 74. Positive controls included cervical low-grade squamous intraepithelial lesion (LSIL) for low-risk HPV probes and cervical adenocarcinoma in situ for high-risk HPV probes.…”

Section: Hpv Rna Ishmentioning

confidence: 99%

Detection of Human Papillomavirus in Squamous Papilloma of the Esophagus

Li,

Lin,

Ling

et al. 2023

Int J Surg Pathol

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Introduction: The etiology of esophageal squamous papilloma (ESP) is largely unknown. Previous studies have shown a variable association with human papillomavirus (HPV) with conflicting data. The aim of this study was to further investigate the possible association of HPV in our ESP series using RNA in-situ hybridization (ISH) and compare study groups from the United States of America and China. Methods: Demographic and clinical data of patients with ESP were retrieved from the University of California Los Angeles (UCLA) (1/2016-3/2019) and Peking Union Medical College Hospital (PUMCH) (9/2014-3/2019) pathology databases. Hematoxylin and eosin slides were reexamined. Confirmed cases were examined by high- and low-risk HPV RNA ISH. Results: For the UCLA cohort, 13 429 upper endoscopies were performed and 78 biopsies from 72 patients were identified as ESP (F:M = 45:27, 66.7% > 45 years). Seventy-four (94.9%) biopsies were designated as polyps or nodules and 46.6% were located in the mid-esophagus. Other abnormal findings included gastroesophageal reflux disease (48.6%), hiatal hernia (38.9%), and esophagitis (36.1%). For the PUMCH cohort, 63 754 upper endoscopies were performed and 73 biopsies from 71 patients were identified as ESP (F:M = 48:23, 71.8% > 45 years). Sixty-four (87.7%) biopsies were designated as polyps or nodules and 57.5% were located in the mid-esophagus. Other abnormal findings included esophagitis (19.7%), and hiatal hernia (8.5%). No features of conventional cytologic dysplasia or viral cytopathic change were found. None of the cases was associated with squamous cell carcinoma, and none showed positive HPV RNA ISH results. Conclusions: No association was found between ESP and active HPV infection in our 2 cohorts. Other etiopathogenetic mechanisms, such as aging, might contribute to the development of these innocent lesions.

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“…В настоящее время взаимосвязь папилломавирусной инфекции и пищеводного папилломатоза все еще не доказана. В литературе описан клинический случай, когда после введения вакцины ВПЧ произошло улучшение состояния пациента [85]. Согласно результатам исследования D. Lavergne и соавт.…”

Section: ýçîôàãèò âûçâàííûé âï×unclassified

Evaluation and management of infectious esophagitis in immunocompromised patients and immunocompetent individuals

Трухманов

Макушина

Сторонова

et al. 2020

Terapevticheskii arkhiv

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Among the many causes of the inflammatory process in the esophagus, infectious diseases are becoming increasingly important due to their steady growth. Previously esophageal infections have traditionally been associated with immunodeficiency syndromes, but now in clinical practice, these disorders are becoming increasingly recognized in immunocompetent individuals. Early diagnosis of infectious esophagitis is necessary to develop effective treatment tactics, and, as a result, reduce the risk of complications and adverse outcomes of the disease. This study reviewed the most clinical relevant pathogens of infectious esophagitis, both among patients with immunodeficiency and among healthy individuals. Specific diagnostic, risk factors, clinical presentation and therapeutic features were considered depending on the immune status of patients.

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Diffuse Esophageal Squamous Papillomatosis Covering the Entire Esophagus

Cited by 9 publications

References 0 publications

Gastrointestinal: Distal esophageal squamous papillomatosis in a healthy 47‐year‐old man

Gastrointestinal: Distal esophageal squamous papillomatosis in a healthy 47‐year‐old man

Detection of Human Papillomavirus in Squamous Papilloma of the Esophagus

Evaluation and management of infectious esophagitis in immunocompromised patients and immunocompetent individuals

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