Diffuse Cutaneous Pseudolymphoma Due to Therapy With Medicinal Leeches

Altamura, Davide; Calonje, Eduardo; Liau, Jia Li; Rogers, Martyn; Verdolini, Roberto

doi:10.1001/jamadermatol.2013.8066

Cited by 15 publications

(21 citation statements)

References 5 publications

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“…Drug‐associated CPL can always resolved completely after drug discontinuation and the time period of regression ranged from a few weeks to few months. Treatment with topical or intralesional corticosteroids resulted in improvement in the skin disease (Altamura et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…CPL designates a group of reactive lymphocytic disorders that involve an inflammatory response to known or unknown stimuli simulating kinds of malignant lymphomas both clinically and histologically (Altamura, Calonje, Liau, Rogers, & Verdolini, 2014). The reactions can be idiopathic or secondary to stimuli including drugs, trauma, insect bites, cowpox vaccinations, and contact dermatitis (Erickson, Nahmias, Rosman, Sternhell-Blackwell, & Musiek, 2018;Miguel, Peckruhn, & Elsner, 2018).…”

Section: Cutaneous Pseudolymphomasmentioning

confidence: 99%

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Lymphoma or pseudolymphoma: A report of six cases and review of the literature

Zhu

Zhang

Wang

et al. 2019

Dermatologic Therapy

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To explore and compare the clinical presentations and pathologic features of cutaneous pseudolymphomas (CPL) with primary cutaneous lymphomas. Review literature in order to improve the treatment of CPL. Six cases of CPLs were collected. The clinical, pathologic, and immunohistochemical features were performed and analyzed in Peking Union Medical College Hospital in 2018. Of six patients, the distributions and clinical manifestations of skin lesions are varied. The pathologic features consisted of atypical prominent lymphocytes infiltration. Of them, two cases imitated mycosis fungoides, one case mimicked primary cutaneous aggressive pidermotropic CD8+ cytotoxic T‐cell lymphoma, one case was diagnosed as Jessner‐Kanof lymphocyte infiltration and two cases primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder. With respect to etiology, one was result from insects bite and the others were on account of drugs. All cases were treated with systemic or local glucocorticoid. The skin lesions and systemic symptoms showed notable improvement after treatment. Follow‐up visits were 2 years, half a year, and months, respectively, without relapse. These unique types of CPL were similar to cutaneous lymphomas in clinical manifestation and pathology. They were all sensitive to the treatment of externally or orally using glucocorticoid. The prognosis is generally good but needs long‐term follow‐up.

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Section: Discussionmentioning

confidence: 99%

Section: Cutaneous Pseudolymphomasmentioning

confidence: 99%

Lymphoma or pseudolymphoma: A report of six cases and review of the literature

Zhu

Zhang

Wang

et al. 2019

Dermatologic Therapy

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“…Cutaneous pseudolymphomas caused by MLA have been rarely reported in the literature. The summary of reported cases are shown in Table [2,[7][8][9][10]. Among the cases, there was only one male patient, the others were women.…”

Section: Discussionmentioning

confidence: 99%

“…Probably the women are more interested in such traditional treatments. In female patients, the leech application was performed due to pain, contrary to an esthetic reason for the male patient [2,[7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

A case of cutaneous pseudolymphoma induced by medicinal leech application and review of the literature

Aktaş¹,

Hamidi²,

Ertuğrul³

et al. 2018

Archives of Clinical and Experimental Medicine

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Medicinal leech application is a common traditional therapy used for various disorders in many cultures for thousands of years. Although it is usually a safe method, serious side effects can also be seen. As a rare side effect of this method, cutaneous pseudolymphoma is a reactive skin disease caused by foreign antigens, infectious processes and arthropod bites. Idiopathic cases sometimes can be seen. In this article, we present a case of cutaneous pseudolymphoma in an elderly woman with multiple nodules over her lumbar region emerging after leech application.Tıbbi sülük uygulaması binlerce yıldır birçok kültürde çeşitli hastalıkların tedavisinde kullanılan yaygın bir geleneksel tedavi yöntemidir. Genellikle güvenli bir yöntem olmasına rağmen, bazen ciddi yan etkiler de görülebilir. Bu metodun nadir bir yan etkisi olarak kutanöz psödolenfoma, yabancı antijenler, enfeksiyöz süreçler, artropod ısırıkları ve bazen idiopatik nedenlerle oluşan reaktif bir deri hastalığıdır. Bu yazıda, sülük uygulaması sonrası çok sayıda nodülü olan ve kutanöz psödolenfoma tanısı konulan bir kadın olguyu sunuyor ve literatürü gözden geçiriyoruz.Anahtar kelimeler: Psödolenfoma, tıbbi sülük, geleneksel yöntemler.

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“…Pseudolymphomatous reaction to leech bites was first described by Smolle et al in 2000 [4]. To the best of our knowledge, English language studies have presented seven other cases so far [5][6][7][8][9][10][11]. Herein, a new case of cutaneous pseudolymphoma is presented at the site of medicinal leech therapy.…”

Section: Introductionmentioning

confidence: 93%

Cutaneous Pseudolymphoma As a Rare Adverse Effect of Medicinal Leech Therapy: A Case Report and Review of the Literature

Sepaskhah¹,

Yazdanpanah²,

Aslani³

et al. 2020

Cureus

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Hirudotherapy (leech therapy) is one of the oldest practices in medical history, and nowadays it is used for several purposes in medicine. Salvage of flaps, wound healing, pain management, and treatment of varicose veins are among the common therapeutic applications of leeches. Complications associated with leech therapy include infections, bleeding, anemia, and allergic reaction. Cutaneous pseudolymphoma (benign proliferation of lymphoid cells in the skin) follows several underlying conditions. Although persistent arthropod bite reaction is one of the conditions associated with cutaneous pseudolymphoma, it has been rarely reported after medicinal leech therapy. Here we describe the case of a patient who presented with cutaneous pseudolymphoma after leech therapy as a rare cutaneous complication of hirudotherapy.

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Diffuse Cutaneous Pseudolymphoma Due to Therapy With Medicinal Leeches

Abstract: The image shows the presence of a dense, nodular, and diffuse infiltrate in the dermis. Note the presence of germinal centers (hematoxylin-eosin, original magnification ×20).

Cited by 15 publications

References 5 publications

Lymphoma or pseudolymphoma: A report of six cases and review of the literature

Lymphoma or pseudolymphoma: A report of six cases and review of the literature

A case of cutaneous pseudolymphoma induced by medicinal leech application and review of the literature

Cutaneous Pseudolymphoma As a Rare Adverse Effect of Medicinal Leech Therapy: A Case Report and Review of the Literature

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