Diffuse cutaneous leishmaniasis: A disease due to an immunological defect of the host

Convit, J; Pinardi, M. E.; Rondon, Antonio

doi:10.1016/0035-9203(72)90306-9

Cited by 164 publications

(102 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The importance of cellular immune responses in the outcome of leishmaniasis has been well established in human (Convit et al 1972, Coutinho et al 1996 and experimental studies (Scott & Farrell 1998). The inability of T-cell-mediated immune responses to control the spread of the parasite could lead to atypical and severe clinical forms and may contribute to an unresponsiveness to anti-leishmanial drugs , Alvar et al 1997, Badaró 1997.…”

Section: Discussionmentioning

confidence: 99%

“…Resolution of cutaneous lesions is associated with a well modulated T-cell response, while an exacerbated immune response seems to be responsible for severe mucosal lesions (Carvalho et al 1985, Coutinho et al 1996. On the other hand, the de-velopment of a specific depressed T-cell mediated immune response leads to diffuse cutaneous leishmaniasis (DCL) (Convit et al 1972). Previous reports from our group describing a DCL-like picture in a patient with AIDS and leishmaniasis suggested that generalized immunosuppression produced by HIV infection was responsible for aggravation of the leishmanial infection, related to the inability of the T-cell-mediated immune response to control the spread of the parasite (DaCruz et al 1992).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy

Da‐Cruz

Filgueiras

Coutinho

et al. 1999

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

An atypical case of acquired immunodeficiency syndrome-associated mucocutaneous lesions due toLeishmania braziliensis is described. Many vacuolated macrophages laden with amastigote forms of the parasite were found in the lesions. Leishmanin skin test and serology for leishmaniasis were both negative. The patient was resistant to therapy with conventional drugs (antimonial and amphotericin B). Interestingly, remission of lesions was achieved after an alternative combined therapy of antimonial associated with immunotherapy (whole promastigote antigens). Peripheral blood mononuclear cells were separated and stimulated in vitro with Leishmania antigens to test the lymphoproliferative responses (LPR). Before the combined immunochemotherapy, the LPR to leishmanial antigens was negligible (stimulation index -SI=1.4). After the first course of combined therapy it became positive (SI=4.17). The antigen responding cells were predominantly T-cells (47.5%) most of them with CD8 + phenotype (33%). Very low CD4 + cells (2.2%) percentages were detected. The increased T-cell responsiveness to leishmanial antigens after combined therapy was accompanied by interferon-γ (IFN-γ) production as

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy

Da‐Cruz

Filgueiras

Coutinho

et al. 1999

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…The host immunological response to the parasite is certainly a major clinical determinant in VL 10,22 .…”

Section: Discussionmentioning

confidence: 99%

Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features

Gama

Gomes

Sílveira

et al. 2013

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Revista da Sociedade Brasileira de Medicina Tropical 46(6):741-745, Nov-Dec, 2013http://dx.doi.org/10.1590/0037-8682-0203-2013 INTRODUCTION ABSTRACT Introduction:The relationship between severe clinical manifestations of visceral leishmaniasis (VL) and immune response profi les has not yet been clarifi ed, despite numerous studies on the subject. This study aimed to investigate the relationship between cytokine profi les and the presence of immunological markers associated with clinical manifestations and, particularly, signs of severity, as defi ned in a protocol drafted by the Ministry of Health (Brazil). Methods: We conducted a prospective, descriptive study between May 2008 and December 2009. This study was based on an assessment of all pediatric patients with VL who were observed in a reference hospital in Maranhão. Results: Among 27 children, 55.5% presented with more than one sign of severity or warning sign. Patients without signs of severity or warning signs and patients with only one warning sign had the highest interferon-gamma (IFN-γ) levels, although their interleukin 10 (IL-10) levels were also elevated. In contrast, patients with the features of severe disease had the lowest IFN-γ levels. Three patients who presented with more than two signs of severe disease died; these patients had undetectable interleukin 2 (IL-2) and IFN-γ levels and low IL-10 levels, which varied between 0 and 36.8pg/mL. Conclusions: Our results showed that disease severity was associated with low IFN-γ levels and elevated IL-10 levels. However, further studies with larger samples are needed to better characterize the relationship between disease severity and cytokine levels, with the aim of identifying immunological markers of active-disease severity.

show abstract

“…The evolution of the disease depends on the species of the protozoa and the host's immune response 10,28 . In human and experimental leishmaniasis, immunity is predominantly mediated by lymphocytes.…”

mentioning

confidence: 99%

Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis

Nogueira

Goto

Sotto

et al. 2008

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SuMMarYAmerican tegumentary leishmaniasis presents as two major clinical forms: localized cutaneous leishmaniasis (LCL) and mucocutaneous leishmaniasis (MCL). The immune response in leishmaniasis is efficiently evaluated by the response to Leishmania antigen through the Montenegro skin test (MST). Both LCL and MCL present positive response to MST, indicating that the patients present cell-mediated immunity against the parasite -Leishmania. In spite of the presence of immunity in MCL, this is not sufficient to stop disease progression and prevent resistance to treatment. In this study we demonstrated interleukin (IL) 2, 4, 5 and interferon (IFN) gamma expression in biopsies of MST of ten patients with American tegumentary leishmaniasis. The obtained results were compared between LCL (n = 5) and MCL (n = 5) patients. The MST of MCL patients displayed a higher expression of IL-2, IL-4 and IL-5, in comparison to LCL. There was no significant difference in IFN-gamma expression between groups. The obtained results suggest the role of IL-4 and IL-5 in the maintenance of the immunopathogenic mechanism of the destructive lesions that characterize MCL.

show abstract

Diffuse cutaneous leishmaniasis: A disease due to an immunological defect of the host

Cited by 164 publications

References 4 publications

Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy

Atypical Mucocutaneous Leishmaniasis Caused by Leishmania braziliensis in an Acquired Immunodeficiency Syndrome Patient: T-cell Responses and Remission of Lesions Associated with Antigen Immunotherapy

Severe visceral leishmaniasis in children: the relationship between cytokine patterns and clinical features

Cytokine profile in Montenegro skin test of patients with localized cutaneous and mucocutaneous leishmaniasis

Contact Info

Product

Resources

About