Diffuse Anterior Retinoblastoma

Abstract

This variant of diffuse retinoblastoma involved only anterior ocular structures with minimal involvement of the retina.

Diffuse Infiltrating Retinoblastoma - Atypical Presentation of Retinoblastoma in late childhood

“…Diffuse infiltrating retinoblastoma, a rare variant of retinoblastoma, shows a unique growth pattern that occurs in 1-2% of cases, in which the tumor grows horizontally with minimal vertical growth. 2 These tumors tend to be unilateral, sporadic, and are more commonly seen in children around the ages of 6-8 years.…”

Diffuse Infiltrating Anterior Retinoblastoma in a 16-Year-Old Boy

“…Even DIR, which often occurs in older children without a distinct mass and without calcification, has characteristic features, as seen in our patient. 1,2,6 There is currently a trend toward treating selected retinoblastomas with chemoreduction combined with thermotherapy, cryotherapy, or brachytherapy. However, DIR, as seen our case, almost always requires enucleation because conservative treatment invariably fails to control diffuse tumor seeding.…”

Glaucoma in Retinoblastoma

“…The first case described a diffuse anterior RB involving primarily the anterior ocular structures with only one microscopic focus in the peripheral retina (Grossniklaus, 1998). This patient presented with glaucoma with increased IOP and anterior and posterior uveitis but had a normal retina in the affected eye.…”

“…The retina and the optic nerve displayed glaucomatous atrophy. The RB tumor circled the lens zonules and ciliary body for a full 360 degrees, extended around the iris, invaded the ciliary body, and seeded the vitreous base and anterior chamber (Grossniklaus, 1998). The second case of RB and NVI was reported in one eye where the RB tumor was limited exclusively to the retina anterior to the equator (Yoshizumi, 1978).…”