Diffuse Alveolar Hemorrhage in Hematopoietic Stem Cell Transplant Recipients and Patients with Hematologic Malignancy

Oncologic emergencies in critical care

“…DAH is characterized by cough, dyspnea, hypoxia, respiratory compromise, and fever without evidence for infection (Afessa, 2011a;Saria and Gosselin-Acomb, 2007). Hemoptysis is uncommon (Afessa, 2011a).…”

“…Hemoptysis is uncommon (Afessa, 2011a). DAH most commonly occurs within the first 30 days after transplant and carries a mortality rate of 76% (Afessa, 2011a). Bronchoscopy may establish the diagnosis.…”

“…DAH most commonly occurs within the first 30 days after transplant and carries a mortality rate of 76% (Afessa, 2011a). Admission to the ICU and use of mechanical ventilation is usually warranted (Afessa, 2011a;Saria and Gosselin-Acomb, 2007). On chest radiograph, unilateral or bilateral alveolar infiltrates may be seen.…”

“…On chest radiograph, unilateral or bilateral alveolar infiltrates may be seen. The optimal steroid dose and schedule has not been identified (Afessa, 2011a). Management includes use of steroids to mediate inflammation (Saria and Gosselin-Acomb, 2007).…”

“…Admission to the ICU and use of mechanical ventilation is usually warranted (Afessa, 2011a;Saria and Gosselin-Acomb, 2007). There are no prospective, randomized trials examining treatment of DAH in the transplant setting (Afessa, 2011a). The optimal steroid dose and schedule has not been identified (Afessa, 2011a).…”