Diffuse alveolar hemorrhage due to metastatic angiosarcoma of the lung: A case report

Pan, Zhijie; Zhou, An; Li, Yanyuan; Zhou, Jianying

doi:10.3892/ol.2015.3820

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…[ 36 ] To the best of our knowledge, 34 cases of metastatic brain angiosarcoma have been reported, half of which were metastases from the heart [ Table 1 ]. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 ] Metastatic lesions of the brain are usually multiple at diagnosis, and differentiation from intracerebral hemorrhages[ 26 ] or cavernous angiomas[ 23 27 ] based only on radiological findings is difficult. Only two previous cases had a history of expanding hematoma in a short period as was observed in our case.…”

Section: Discussionmentioning

confidence: 99%

Pyothorax-associated angiosarcoma metastasized to the brain with multiple and progressively expanding hematomas: Case report and literature review

et al. 2018

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The brain metastasis of angiosarcoma is very rare, and little is known about its clinical features or therapeutic strategy. A 74-year-old male was hospitalized for disturbance of consciousness. Radiological examination revealed multiple cerebral hematomas. Gadolinium contrast-enhanced magnetic resonance imaging showed no significant enhancement at any of the lesions. To detect a suspected metastatic brain tumor or abscess, a full-body scan was performed but revealed only a poorly enhanced mass in the removal cavity caused by thoracoplasty in the left upper chest. After admission, a cascade of expansion of those hematomas occurred in the right frontal, left parietal, and right temporal lobes, and each lesion thus had to be sequentially removed by craniotomies. The pathological diagnosis of the right frontal lesion was an abscess with hematoma. However, a malignant vascular tumor was highly suspected because of many CD31(+)/Ki-67(+) cells in the left parietal lesion. A mass in the scar caused by thoracoplasty was suspected to be the primary lesion, and brain metastasis of angiosarcoma was finally diagnosed. Whole-brain irradiation and systemic paclitaxel administration were performed, and a complete response for the brain lesions was obtained for 22 months; the patient then died of an intratracheal hemorrhage. This case represents the first report of multiple brain metastases from pyothorax-associated angiosarcoma accompanied by sequentially and gradually expanding hematomas, as well as the first case with the control of metastatic brain lesions for over 1 year after the onset of neurological symptoms. Control of the lesions could be achieved by their total removal with complete hemostasis, as well as additional radio- and chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Pyothorax-associated angiosarcoma metastasized to the brain with multiple and progressively expanding hematomas: Case report and literature review

et al. 2018

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“…Angiosarcomas are a group of vascular malignant tumors that are relatively rare and account for 1-2% of all soft tissue sarcomas (1). With an extremely poor prognosis, patients with angiosarcomas always ending within a year (2). They originate from vascular or lymphatic epithelial cells and can arise in various locations of the body (3,4).…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Different Treatment Modalities of Cutaneous Angiosarcoma: Results From Meta-Analysis and Observational Data From SEER Database

Chen

et al. 2021

Front. Oncol.

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IntroductionCutaneous angiosarcoma (cAS) is an aggressive vascular tumor that originates from vascular or lymphatic epithelial cells. To date, the cAS literature has been limited in a small number with single-center experiences or reports due to its rarity and the optimal treatment strategy is still in dispute. This study aimed to conduct a systematic review and compare the effect of available treatments retrieved from observational studies and Surveillance, Epidemiology, and End Results (SEER) program.MethodsThe authors performed a systematic review in the PubMed, Embase and MEDLINE database identifying the researches assessing the treatment for cAS patients. Clinical and treatment information of patients who had been diagnosed with a primary cAS were also obtained from the SEER program.ResultsThirty-two studies were eligible but only 5 of which with 276 patients were included in meta-analysis since the unclear or unavailable information. The risk ratio of 5-year death for surgery, surgery with radiotherapy and surgery with chemotherapy were 0.84, 0.96, and 0.69. Meanwhile, in SEER database, there are 291 metastatic and 437 localized patients with cAS. The localized patients receiving surgery showed a significantly worse overall survival result when compared with the surgery combined with RT: hazard ratio: 1.6, 95% confidential interval: 1.05, 2.42, P = 0.03.ConclusionIn conclusion, our study provided a detailed picture of the effectiveness of present treatments for localized and metastatic cAS patients. The CT could be inappropriate in localized patients. For metastatic patients, the surgery combined RT was recommended compared with surgery alone since its enhanced OS prognosis. Yet, more novel-designed clinical trials with specific targeted populations and rigorous conducting are needed for a solid conclusion on which would be a better treatment strategy.

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“…The clinical features of angiosarcoma vary according to the tumor site, ranging from asymptomatic cutaneous papule to deeper site bleeding, hemothorax, and pain. Although the lung is the most common site of metastasis, diffuse alveolar hemorrhage (DAH) is a very rare manifestation of pulmonary metastatic angiosarcoma, and most case reports have shown extremely poor prognosis [ [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] ]. We report a case to illustrate the clinical importance of proper diagnosis and treatment in patients with metastatic angiosarcoma with these dangerous clinical presentations.…”

Section: Introductionmentioning

confidence: 99%

Diffuse alveolar hemorrhage from metastatic cardiac angiosarcoma of the lung successfully treated with paclitaxel chemotherapy: A case report and brief literature review

Yang

Park

Han

et al. 2021

Respiratory Medicine Case Reports

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Diffuse alveolar hemorrhage due to metastatic angiosarcoma of the lung: A case report

Cited by 4 publications

References 14 publications

Pyothorax-associated angiosarcoma metastasized to the brain with multiple and progressively expanding hematomas: Case report and literature review

Pyothorax-associated angiosarcoma metastasized to the brain with multiple and progressively expanding hematomas: Case report and literature review

The Effectiveness of Different Treatment Modalities of Cutaneous Angiosarcoma: Results From Meta-Analysis and Observational Data From SEER Database

Diffuse alveolar hemorrhage from metastatic cardiac angiosarcoma of the lung successfully treated with paclitaxel chemotherapy: A case report and brief literature review

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