Nowadays, the Novosibirsk free electron laser (NovoFEL) is the most intense radiation source in the terahertz spectral range. It operates in the continuous mode with a pulse repetition rate of up to 11.2 MHz (5.6 MHz in the standard mode) and an average power of up to 500 W. The radiation wavelength can be precisely tuned from 120 to 240 mm with a relative line width of 0.3-1%, which corresponds to the Fourier transform limit for a micropulse length of 40-100 ps. The laser radiation is plane-polarized and completely spatially coherent. The radiation is transmitted to six user stations through a nitrogen-filled beamline. Characteristics of the NovoFEL radiation differ drastically from those of conventional low-power (and often broadband) terahertz sources, which enables obtaining results impossible with other sources, but necessitates the development of special experimental equipment and techniques. In this paper, we give a review of the instrumentation developed for control and detection of high-power terahertz radiation and for the study of interaction of the radiation with matter. Quasi-optic elements and systems, one-channel detectors, power meters, real-time imagers, spectroscopy devices and other equipment are described. Selected experimental results (continuous optical discharge, material and biology substance ablation, real-time imaging attenuated total reflection spectroscopy, speckle metrology, polarization rotation by an artificial chiral structure, terahertz radioscopy and imaging) are also presented in the paper. In the near future, after commissioning another four electron racetracks and two optical resonators, intense radiation in the range from 5 to 240 μm will be available for user experiments.