Diffraction under total internal reflection for micro-fluidic analysis

Sarov, Y.; Ivanov, Tzv.; Sarova, V.; Capek, Ignác; Rangelow, Ivo W.

doi:10.1007/s00339-006-3597-x

Cited by 7 publications

(15 citation statements)

References 22 publications

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“…Tests with biotin/ streptavidin assays were conducted to demonstrate detection of small molecule binding. Sarov et al (2006) employed a grating realised with a PMMA microprism on a glass microchannel lid, requiring multi-step fabrication. Laser light enters the prism under total internal reflection, so that the grating is irradiated and an evanescent field penetrates the microchannel.…”

Section: Refractive Index Techniquesmentioning

confidence: 99%

Optofluidic integration for microanalysis

Hunt

Wilkinson

2007

Microfluid Nanofluid

129

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This review describes recent research in the application of optical techniques to microfluidic systems for chemical and biochemical analysis. The ''lab-on-achip'' presents great benefits in terms of reagent and sample consumption, speed, precision, and automation of analysis, and thus cost and ease of use, resulting in rapidly escalating adoption of microfluidic approaches. The use of light for detection of particles and chemical species within these systems is widespread because of the sensitivity and specificity which can be achieved, and optical trapping, manipulation and sorting of particles show significant benefits in terms of discrimination and reconfigurability. Nonetheless, the full integration of optical functions within microfluidic chips is in its infancy, and this review aims to highlight approaches, which may contribute to further miniaturisation and integration.

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Section: Refractive Index Techniquesmentioning

confidence: 99%

Optofluidic integration for microanalysis

Hunt

Wilkinson

2007

Microfluid Nanofluid

129

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“…First, for all studied dispersions the relative DE change is positive at s polarization (the zeroth order gains energy at an increase of the concentration and, respectively, of the ERI). The opposite response occurs for the p polarization; the η 0 diminishes for higher c. Such peculiarity of the polarization behavior is typical for a phase performance of the TIR-DR, that is, when transparent fluids are sensed 20 (no absorption or r t ) 1). The energy redistribution of the diffraction pattern in this regime is determined by the variations of the TIR phase Φ t , caused by RI changes.…”

mentioning

confidence: 95%

“…[13][14] In our previous works, the first autonomous microrealization of a TIR-DG for uniform microfluid analysis is described. [19][20] Here, a TIR-DG is utilized for quantitative characterization of nanoparticle suspensions for the first time. A wide variety of liquid dispersions with polymeric, metallic, and ferromagnetic nanoparticles are investigated.…”

mentioning

confidence: 99%

“…Moreover, the behavior of all high-order diffracted waves is opposite to that of the zeroth (as a consequence of the constant total diffracted power). 20 Finally, using only one photodetector simplifies the experiments and the processing of the data.…”

mentioning

confidence: 99%

“…Although for some applications such an error could be acceptable, it can be also seen that the average value N h SRRI in all cases coincides much better (2-4%) with the references. The earlier investigations of the TIR-DG sensors 15,17,20 have dealt either with pure transparent (variable n, k ) 0) samples either with pure absorbing fluid (n ) const, variable k). The first case is accompanied by an exchange of energy between the zeroth and the (first diffraction orders (the strengthening of the zeroth order is connected with weakening of the (first orders and vice versa).…”

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confidence: 99%

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On Total Internal Reflection Investigation of Nanoparticles by Integrated Micro-Fluidic System

et al. 2007

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We report on a novel sensor for characterization of nanoparticles colloidal suspensions. We employ a diffraction grating under total internal reflection for investigation of nanodisperse fluids passing through an integrated microfluidic channel. Dispersions containing polymeric, metallic, and ferromagnetic nanoparticles are studied. Using this device, we can accurately determine in real-time the specific refractive index for the nanoparticle suspension and the nanoparticle concentration. The nanoparticle concentrations can be calculated with a resolution of 0.3-0.5 wt% for polymeric nanoparticles, 0.03-0.05 wt% for metallic nanoparticles, and 0.05-0.1 wt% for ferromagnetic nanoparticles. This translates to an effective refractive index that can be determined with an accuracy of 7 x 10(-4) for the polymeric and 2 x 10(-4) for the metallic and ferromagnetic dispersions.

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