Difficulties involved in diaminobenzidine histochemistry of endogenous peroxidase

Bogaert, Louis-Jacques van; Quikokes, Jorge Abarca; Craynest, Marie-Paule van

doi:10.1016/s0065-1281(80)80022-5

Cited by 4 publications

(1 citation statement)

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“…Mexiletine has been used in the treatment of acute and chronic ventricular arrhythmias associated with various cardiac diseases (3)(4)(5)(6). The quantitative determination of mexiletine is important both for monitoring and optimizing blood levels of patients receiving therapeutic doses, and for studying the pharrnacokinetic properties of the drug (7,8,9). Several gas4iquid Chromatographie methods are available for measuring the circulating concentrations of mexiletine (10-rl5).…”

Section: Introductionmentioning

confidence: 99%

Gas-Liquid Chromatographie Determination of Mexiletine in Human Serum with Nitrogen Sensitive Detection

S¹,

Svens²,

Leskinen³

1981

CCLM

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A simple and rapid method for the quantitative determination of mexiletine, using gas-liquid chromatography with nitrogen sensitive detection, is described. Only one extraction step is needed, the recovery is between 92-96% and the precision varies between 2.0-5.5%. The lower limit of detection reached 0.5 μιηοΐ/ΐ. During routine handling the method was easy, quick and cheap. Gaschromatographische Bestimmung von Mexiletine im Serum mit StickstoffdetektorZusammenfassung: Eine einfache und schnelle Bestimmungsmethode f r Mexiletine im Serum mittels Gaschromatographie mit Stickstoffdetektor wird beschrieben. Eine einmalige Extraktion ist ausreichend, die Wiederfindungsrate betr gt 92-96%, die Genauigkeit variiert zwischen 2,0 und 5,5%. Die Nachweisgrenze liegt bei 0,5 μιηοΐ/ΐ. Im Rahmen von Routinebestimmungen hat sich die Methode als spezifisch, zeitsparend und billig erwiesen.

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