Difficulties in diagnosis of supratentorial gliomas by CAT scan.

Kendall, B. E.; Jakubowski, Jan; Pullicino, Patrick; Symon, Lindsay

doi:10.1136/jnnp.42.6.485

Cited by 50 publications

(5 citation statements)

References 7 publications

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“…The scan review was, in the main, retrospective and the accuracy rates found here may not be repeatable in a prospective study. In 1979, Kendall et al 11reported a series of 314 histologically established gliomas of all types scanned on an EMI 1010 machine. They found 26 cases misclassified for an overall accuracy of 91.8%.…”

Section: Discussionmentioning

confidence: 99%

Incidence of brain tumours in two English counties: a population based study

Pobereskin

Chadduck²

2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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Results-16 923 scans were reviewed of which 8774 (52%) were normal. The scan review found 2483 incident intracranial tumours, of which 861 were metastases. Secondary sources of case ascertainment disclosed 46 further cases. Cases were missed by the scan review mainly for technical reasons and only three patients were found who were diagnosed by nonimaging methods. The incidence of primary intracranial tumours standardised to the population of England and Wales was higher than any previously reported (21.04 (17.18-25.62)/100 000 person-years). Overall, 21% of cases were not admitted to hospital. The categories least likely to be admitted were those with sellar and cranial nerve tumours. Those not admitted to hospital were significantly older than those who were. Conclusion-One fifth of patients are not admitted to hospital after the diagnosis of a brain tumour and incidence studies must use case finding methods which will capture these cases. An audit of imaging results provides almost complete case ascertainment. This study shows that the incidence of primary brain tumours is considerably higher than previously thought. OYcial figures from the cancer intelligence units significantly underestimate brain tumour incidence, especially for benign tumours. (J Neurol Neurosurg Psychiatry 2000;69:464-471) Keywords: intracranial tumour; epidemiology; incidence Accurate information about incidence of disease is important for many reasons. Comparison of rates across time and space can give clues to aetiology and accurate data is needed for informed public health debate and for healthcare resource planning. Definition of disease "clusters", a controversial issue, is impossible without precise knowledge of background incidence.Information on the incidence of brain tumours in the United Kingdom comes from the tumour registries of the regional cancer intelligence units and from four previous studies. The first two studies took place before the era of CT.1 2 A more recent hospital based study from south Wales reported a crude rate of 5.6/100 000/year. 3 The most recent population based study from Lothian used multiple sources to identify incident cases and reported a crude rate of 15.3/100 000/year. 4 The same group reviewed a large number of incidence studies and found that the incidence of tumours was positively related to the number of case finding sources used. 5 No information was given in either study, however, on which sources were the most informative.Imaging of the brain has advanced dramatically in the past 20 years and now provides highly accurate information about intracranial structures, with very little perceived risk. This technology is widely available, and its use has become necessary, and in many cases suYcient, for the diagnosis of various intracranial conditions. As a result, over recent years a patient who presents with symptoms of an intracranial tumour is scanned as a matter of routine.An audit of CT and MRI results would seem to be an ideal way to obtain accurate information about incidence of brain t...

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Section: Discussionmentioning

confidence: 99%

Incidence of brain tumours in two English counties: a population based study

Pobereskin

Chadduck²

2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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“…CT-as. 3 Number of tissue samples There were 93 cases, in which the numbers of biopsy samples were evaluable (table 4). Among 80 cases in which a stereotactic biopsy was performed, the initial specimen, which was usually obtained from the periphery of the lesion delineated on CT was sufficient for exact histological diagnosis in 51 cases (64%).…”

Section: General Aspectsmentioning

confidence: 99%

CT-assisted stereotactic brain biopsy: value of intraoperative frozen section diagnosis.

Colbassani

Nishio

Sweeney

et al. 1988

Journal of Neurology, Neurosurgery & Psychiatry

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“…Gliomas are the most common type of primary central nervous system tumor and account for about one-half of confirmed primary intracranial neoplasms (1)(2)(3). The current methods for imaging central nervous system tumors depend either on agents that image the disruption of the blood-brain barrier by the tumor or on agents that image edema and density changes within the tumor and surrounding brain tissue (4)(5)(6)(7)(8). The current methods, however, cannot distinguish between healthy brain and brain infiltrated with tumor cells.…”

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confidence: 99%