Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure

Abstract

We evaluated the in vitro phagocytic function and the production of microbicidal oxygen radicals by monocytes and neutrophils of 9 Chagas' heart disease subjects with heart failure and 9 without the syndrome in comparison with 11 healthy subjects, by assessing phagocytosis of Saccharomyces cerevisiae and NBT reduction by peripheral blood phagocytes.

Morphological changes in eosinophils are reliable markers of the severity of an acute asthma exacerbation in children

“…The correlation between the severity of asthma exacerbation and morphological changes observed in this work demonstrates the level of activation of eosinophil in these individuals. Using this technique to separate the polymorphonuclear cells directly from the whole blood has also been used to assess phagocytosis and the influence of drugs on phagocyte functions .…”

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“…Studies in humans have provided indirect evidence for the oxidative function of activated macrophages and neutrophils [12,[31][32][33][34]. It was recently demonstrated the interlinked effects of inflammatory responses, antioxidant status and oxidant levels in human ChHD [12,26,35].…”

Involvement of neutrophils in Chagas disease pathology

“…Neutrophils of patients with the chagasic cardiac form, incubated in vitro with T cruzi, have a greater capacity to phagocyte the parasites than neutrophils of individuals with the indeterminate form of the disease . On the other hand, Gomes and collaborators found that neutrophils from patients with indeterminate and cardiac forms did not present differences in phagocytosis in relation to healthy individuals, but regardless of their steady T cruzi phagocytic capacity; neutrophils from IND patients displayed a lower ability to produce cytokines, such as IL‐17, IFN‐γ, IL‐4 and IL‐10, in the presence of autologous plasma .…”