Differing correlates for suicide attempts among patients with schizophrenia or schizoaffective disorder in India and USA

Bhatia, Triptish; Thomas, Pramod; Semwal, Prachi; Thelma, B.K.; Nimgaonkar, Vishwajit L.; Deshpande, Smita N.

doi:10.1016/j.schres.2006.04.015

Cited by 37 publications

(23 citation statements)

References 33 publications

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“…This is comparable to the findings by Bhatia et al (2006) from the same center nine years ago, where they reported a prevalence of around 23% as opposed to 20–40% from world literature (Pompili et al, 2007). …”

Section: Discussionsupporting

confidence: 87%

“…From mean of attempters and nonattempters, effect size was calculated as 0.66. Considering the prevalence of suicide attempters in India as 30% in schizophrenia/schizoaffective disorders (Bhatia et al, 2006), sample size was calculated using G power (http:/www.surveysystem.com/sscalc.htm), by taking alpha = 0.05 and power = 90%. The method was used for t -test (Means: Wilcoxon-Mann-Whitney Test, two groups).…”

Section: Sample Sizementioning

confidence: 99%

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Lifetime suicide intent, executive function and insight in schizophrenia and schizoaffective disorders

Verma

Srivastava

Singh

et al. 2016

Schizophrenia Research

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Objectives Lack of insight and neurocognitive deficits are often seen in schizophrenia patients. While there are several studies investigating the relationship between suicidal ideation, executive function and insight, there are relatively fewer investigating the triangular relationship between suicide intent, insight and cognitive competence in schizophrenia. The aim of our study was to address this issue. Methods One hundred seventy five subjects with DSM-IV TR diagnoses of schizophrenia or schizoaffective disorder were enrolled and the diagnosis was established using the Hindi version of the Diagnostic Interview for Genetic Studies and other available information in consultation with a Board certified senior Psychiatrist. All the subjects were interviewed on Beck’s cognitive insight scale and tested on the Trail Making Test. All the subjects who had lifetime history of suicide attempt were interviewed on Pierce’s suicide intent scale. Results Ever attempters scored significantly higher on Beck’s cognitive insight scale (p = 0.012) and outperformed non-attempters on Trail Making Test A and B (p = 0.026 and p = 0.012 respectively), indicating better executive functions in the former. However among ever attempters, significant relationship was not found between executive functions, insight and severity of suicide intent. Conclusion Our study suggests that good insight and better executive functioning may be significantly correlated with suicide attempts at some time during the course of illness. Patients with schizophrenia should be evaluated for potential suicidality once denial, neurocognitive deficits and other factors associated with poor insight abate.

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Section: Discussionsupporting

confidence: 87%

Section: Sample Sizementioning

confidence: 99%

Lifetime suicide intent, executive function and insight in schizophrenia and schizoaffective disorders

Verma

Srivastava

Singh

et al. 2016

Schizophrenia Research

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“…An earlier study from the same centre had reported 23.3% of attempted suicides among schizophrenia participants (Bhatia et al, 2006), they had included both schizophrenia and schizoaffective disorder while ours was a sample of schizophrenia participants only. Additionally, we included only those who reported clear intentionality and lethality.…”

Section: Discussionmentioning

confidence: 89%

Self-harm and suicide attempts in Schizophrenia

Jakhar

Beniwal

Bhatia

et al. 2017

Asian Journal of Psychiatry

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Background The risk of suicide among persons with schizophrenia (SZ) is higher than in general population, with multiple contributory factors. We assessed the prevalence of risk of deliberate self-harm and suicide attempts, along with associated socio-demographic and clinical factors in a group of SZ outpatients (n=61) as part of a larger study on overall schizophrenia-associated risks. Aims To investigate factors associated with risk of deliberate self-harm and suicide among persons with schizophrenia. Method Out of 270 SZ participants evaluated for various risks using Ram Manohar Lohia Risk Assessment Interview (RML-RAI), 61 reported risk of self-harm including suicide attempt/s. The factors associated with this risk were further evaluated on clinical details and Diagnostic Interview for Genetic Studies. Results Risk of reported self-harm was 22.59%. Among them, 10% had attempted suicide at least once. Current age and past month Global Assessment of Functioning score from DIGS (GAF) were significantly correlated with suicide attempt. Attempters had significantly lower current GAF score, indicating poorer functioning. Among 27 attempters, 9 attempted at the onset of illness while 6 others attempted suicide within one year. Most common method of attempt was ingestion of insecticides or overdose of medication, followed by hanging or jumping from height. Conclusion In our hospital-based sample of suicide attempters, 10% had attempted suicide, among them over 55% within first year of illness. Attempters were significantly older than non-attempters and suffered from significantly more severe illness than non-attempters. Positive symptoms were significantly associated with attempt, irrespective of time at which suicide was attempted.

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“…Based on this information, consensus diagnoses were established by certified psychiatrists and psychologists using DSM IV criteria. Inter-rater and inter-site diagnostic reliability was checked throughout the study and Kappa values of 0.8 or greater were aimed for (Bhatia et al, 2006). …”

Section: Methodsmentioning

confidence: 99%

Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort

Kukshal

Kodavali

Srivastava

et al. 2013

Journal of Psychiatric Research

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Background Associations of polymorphisms from dopaminergic neurotransmitter pathway genes have been reported in Caucasian ancestry schizophrenia (SZ) samples. As studies investigating single SNPs with SZ have been inconsistent, more detailed analyses utilizing multiple SNPs with the diagnostic phenotype as well as cognitive function may be more informative. The analyses were conducted in a north Indian sample. Methods Indian SZ case-parent trios (n = 601 families); unscreened controls (n= 468) and an independent set of 118 trio families were analyzed. Representative SNPs in the Dopamine D3 receptor (DRD3), dopamine transporter (SLC6A3), vesicular monoamine transporter 2 (SLC18A2), catechol-o-methyltransferase (COMT) and dopamine beta hydroxylase (DBH) were genotyped using SNaPshot/SNPlex assays (n=59 SNPs). The Trail Making Test (TMT) was administered to a subset of the sample (n=260 cases and_n=302 parents). Results Eight SNPs were nominally associated with SZ in either case-control or family based analyses (p<0.05, rs7631540 and rs2046496 in DRD3; rs363399 and rs10082463 in SLC18A2; rs4680, rs4646315 and rs9332377 in COMT). rs6271 at DBH was associated in both analyses. Haplotypes of DRD3 SNPs incorporating rs7631540-rs2134655-rs3773678-rs324030-rs6280-rs905568 showed suggestive associations in both case-parent and trio samples. At SLC18A2, rs10082463 was nominally associated with psychomotor performance and rs363285 with executive functions using the TMT but did not withstand multiple corrections. Conclusions Though suggestive associations with dopaminergic genes were detected in this study, but convincing links between dopaminergic polymorphisms and SZ or cognitive function were not observed.

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Differing correlates for suicide attempts among patients with schizophrenia or schizoaffective disorder in India and USA

Cited by 37 publications

References 33 publications

Lifetime suicide intent, executive function and insight in schizophrenia and schizoaffective disorders

Lifetime suicide intent, executive function and insight in schizophrenia and schizoaffective disorders

Self-harm and suicide attempts in Schizophrenia

Dopaminergic gene polymorphisms and cognitive function in a north Indian schizophrenia cohort

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