Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats

Li, Shan-Bing; Li, Yi-Fang; Mao, Zhong-Fu; Hui-hua, HU; Ouyang, Shu-Hua; Wu, Yanping; Tsoi, Bun; Gong, Pin; Kojima, Hiroshi; He, Rong‐Rong

doi:10.1002/jsfa.6811

Cited by 11 publications

(11 citation statements)

References 44 publications

(45 reference statements)

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“…To date this is the first investigation to examine the impact of DYM on resting heart rate, while a few investigations examined TCR. Li et al [34] examined the effects of TCR (30 mg/kg) on resting heart rate of hypertensive and normotensive rats at baseline, as well as every 30 min up to 180 min post TCR administration. No changes in resting heart rate were found.…”

Section: Cardiovascular Functionmentioning

confidence: 99%

Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults

et al. 2020

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Methylliberine (Dynamine®; DYM) and theacrine (Teacrine®; TCR) are purine alkaloids purported to have similar neuro-energetic effects as caffeine. There are no published human safety data on DYM, and research on TCR is limited. The purpose of this study was to examine the effect of four weeks of DYM supplementation with and without TCR on cardiovascular function and blood biomarkers. One-hundred twenty-five men and women (mean age 23.0 yrs, height 169.7 cm, body mass 72.1 kg; n = 25/group) were randomly assigned to one of five groups: low-dose DYM (100 mg), high-dose DYM (150 mg), low-dose DYM with TCR (100 mg + 50 mg), high-dose DYM with TCR (150 mg + 25 mg), and placebo. Regardless of group and sex, significant main effects for time were noted for heart rate, systolic blood pressure, and QTc (p < 0.001), high-density lipoproteins (p = 0.002), mean corpuscular hemoglobin (p = 0.018), basophils (p = 0.006), absolute eosinophils (p = 0.010), creatinine (p = 0.004), estimated glomerular filtration rate (p = 0.037), chloride (p = 0.030), carbon dioxide (p = 0.023), bilirubin (p = 0.027), and alanine aminotransferase (p = 0.043), among others. While small changes were found in some cardiovascular and blood biomarkers, no clinically significant changes occurred. This suggests that DYM alone or in combination with TCR consumed at the dosages used in this study does not appear to negatively affect markers of health over four weeks of continuous use.

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Section: Cardiovascular Functionmentioning

confidence: 99%

Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults

et al. 2020

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“…kucha (3 g/kg caffeine and 22 g/kg theacrine) did not lead to increases in blood pressure and heart rate in spontaneously hypertensive rats [10]. When rats were given 30 mg/kg caffeine, theobromine, or theacrine, only the caffeine treatment had a significant effect on cardiovascular parameters [10]. …”

Section: Introductionmentioning

confidence: 99%

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Clewell

Hirka²,

Glávits³

et al. 2016

Journal of Toxicology

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A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses of 0 (vehicle only), 180, 300, and 375 mg/kg bw/day. Two females and one male in the 300 and 375 mg/kg bw/day groups, respectively, died during the study. Histological examination revealed centrilobular hepatocellular necrosis as the probable cause of death. In 375 mg/kg bw/day males, slight reductions in body weight development, food consumption, and feed efficiency, decreased weight of the testes and epididymides and decreased intensity of spermatogenesis in the testes, lack or decreased amount of mature spermatozoa in the epididymides, and decreased amount of prostatic secretions were detected at the end of the three months. At 300 mg/kg bw/day, slight decreases in the weights of the testes and epididymides, along with decreased intensity of spermatogenesis in the testes, and lack or decreased amount of mature spermatozoa in the epididymides were detected in male animals. The NOAEL was considered to be 180 mg/kg bw/day, as at this dose there were no toxicologically relevant treatment-related findings in male or female animals.

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“…Moreover, the consumption of green tea extract (2 and 4 g/kg diet) was observed to benefit blood pressure and to improve inflammation and antioxidant status in NaCl-induced hypertensive rats [125]. However, results from another animal study argued that heavy tea consumption might be unsuitable for hypertensive subjects [126]. It was found that feeding of tea extract (300 mg/kg BW) induced an acute increase in systolic/diastolic blood pressure and heart rate in spontaneously hypertensive rats, which might be mediated by regulating plasma epinephrine and norepinephrine levels.…”

Section: Cardiovascular-protective Effect In Vivomentioning

confidence: 99%

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

Tang

Meng

Gan

et al. 2019

IJMS

216

150

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Tea is widely consumed all over the world. Generally, tea is divided into six categories: White, green, yellow, oolong, black, and dark teas, based on the fermentation degree. Tea contains abundant phytochemicals, such as polyphenols, pigments, polysaccharides, alkaloids, free amino acids, and saponins. However, the bioavailability of tea phytochemicals is relatively low. Thus, some novel technologies like nanotechnology have been developed to improve the bioavailability of tea bioactive components and consequently enhance the bioactivity. So far, many studies have demonstrated that tea shows various health functions, such as antioxidant, anti-inflammatory, immuno-regulatory, anticancer, cardiovascular-protective, anti-diabetic, anti-obesity, and hepato-protective effects. Moreover, it is also considered that drinking tea is safe to humans, since reports about the severe adverse effects of tea consumption are rare. In order to provide a better understanding of tea and its health potential, this review summarizes and discusses recent literature on the bioactive components, bioavailability, health functions, and safety issues of tea, with special attention paid to the related molecular mechanisms of tea health functions.

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Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats

Abstract: The different effects of C. sinensis, C. ptilophylla and C. assamica var. kucha on BP might be explained, at least partially, by the differences in the varieties and contents of purine alkaloids.

Cited by 11 publications

References 44 publications

Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults

Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults

A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Health Functions and Related Molecular Mechanisms of Tea Components: An Update Review

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