Differentiation of trophoblast endocrine cells

Soares, Michael J.; Chapman, Brian; Rasmussen, Christine A.; Dai, Guoli; Kamei, Takayuki; Orwig, Kyle E.

doi:10.1016/s0143-4004(96)90051-x

Cited by 121 publications

(112 citation statements)

References 118 publications

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“…AF 139808. ) 1995, Soares et al 1996). As a result of interactions with the maternal stromal compartment and fetal mesenchyme, the ectoplacental cone develops into two recognizable zones: the junctional zone and the labyrinth zone (Soares et al 1996) (Fig.…”

Section: Organization Of the Chorioallantoic Placentamentioning

confidence: 99%

“…7). The junctional zone is situated at the maternal interface and is comprised of three differentiated trophoblast lineages, trophoblast giant cells, spongiotrophoblast, and glycogen cells, whereas the labyrinth zone is located at the fetal interface and consists of trophoblast giant cells, syncytial trophoblast cells, and fetal mesenchyme and vasculature (Soares et al 1996). Trophoblast giant cells and spongiotrophoblast cells are principally involved in the biosynthesis of members of the PRL family (Soares et al 1998).…”

Section: Organization Of the Chorioallantoic Placentamentioning

confidence: 99%

“…Trophoblast giant cells and spongiotrophoblast cells arise through the activation of distinct regulatory programs at temporally disparate developmental phases (Guillemot et al 1994, Cross et al 1995, Rossant et al 1998. Trophoblast giant cells represent the first differentiated trophoblast lineage originating shortly after implantation, and are situated at the maternal-placental interface (Rossant 1995, Soares et al 1996. Spongiotrophoblast cells develop concurrently with the establishment of the chorioallantoic placenta at midgestation and are located beneath the trophoblast giant cell layer (Rossant 1995, Soares et al 1996.…”

Section: Plp-fmentioning

confidence: 99%

“…Trophoblast giant cells represent the first differentiated trophoblast lineage originating shortly after implantation, and are situated at the maternal-placental interface (Rossant 1995, Soares et al 1996. Spongiotrophoblast cells develop concurrently with the establishment of the chorioallantoic placenta at midgestation and are located beneath the trophoblast giant cell layer (Rossant 1995, Soares et al 1996. As a result, it is apparent that PLP-F has access to potentially different physiological compartments, depending on its sites of synthesis in the rat and in the mouse.…”

Section: Plp-fmentioning

confidence: 99%

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Identification of two new nonclassical members of the rat prolactin family

Sahgal¹,

Knipp²,

Liu³

et al. 2000

Journal of Molecular Endocrinology

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The prolactin (PRL) family is comprised of a group of hormones/cytokines that are expressed in the anterior pituitary, uterus, and placenta. These proteins participate in the control of maternal and fetal adaptations to pregnancy. In this report, we have identified two new nonclassical members of the rat PRL family through a search of the National Center for Biotechnology Information dbEST database. The cDNAs were sequenced and their corresponding mRNAs characterized. Overall, the rat cDNAs showed considerable structural similarities with mouse proliferin-related protein (PLF-RP) and prolactin-like protein-F (PLP-F), consistent with their classification as rat homologs for PLF-RP and PLP-F. The expression of both cytokines/hormones was restricted to the placenta. The intraplacental sites of PLF-RP and PLP-F synthesis differed in the rat and the mouse. In the mouse, PLF-RP was expressed in the trophoblast giant cell layer of the midgestation chorioallantoic and choriovitelline placentas and, during later gestation, in the trophoblast giant cell and spongiotrophoblast layers within the junctional zone of the mouse chorioallantoic placenta. In contrast, in the rat, PLF-RP was first expressed in the primordium of the chorioallantoic placenta (ectoplacental cone region) and, later, exclusively within the labyrinth zone of the chorioallantoic placenta. In the mouse, PLP-F is an exclusive product of the spongiotrophoblast layer, whereas in the rat, trophoblast giant cells were found to be the major source of PLP-F, with a lesser contribution from spongiotrophoblast cells late in gestation. In summary, we have established the presence of PLF-RP and PLP-F in the rat.

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Section: Organization Of the Chorioallantoic Placentamentioning

confidence: 99%

Section: Organization Of the Chorioallantoic Placentamentioning

confidence: 99%

Section: Plp-fmentioning

confidence: 99%

Section: Plp-fmentioning

confidence: 99%

See 2 more Smart Citations

Identification of two new nonclassical members of the rat prolactin family

Sahgal¹,

Knipp²,

Liu³

et al. 2000

Journal of Molecular Endocrinology

View full text Add to dashboard Cite

show abstract

“…Invasive trophoblast cells have their origins in stem and precursor cells arising from trophectoderm during the first differentiation events of embryo development and are subsequently situated within a region of the rodent chorioallantoic placenta termed the junctional zone. 9,10 These stem/precursor cells also seed distinct trophoblast cell lineages in the labyrinth zone, which specialize in bidirectional transport of nutrients and wastes between maternal and fetal compartments. 11 modifications, which is viewed as a maternally protective adaptation.…”

mentioning

confidence: 99%