Differentiation of Tarchonanthus camphoratus L. and Tarchonanthus parvicapitulatus P.P.J. Herman (Asteraceae) using electron microscopy, and comparison of their biological activities

Aro, A.O.; Famuyide, Ibukun M.; Elisha, Ishaku Leo; Kabongo-Kayoka, Prudence N.; McGaw, Lyndy Joy; Kahler-Venter, Christina P.

doi:10.1016/j.jep.2020.113620

Journal of Ethnopharmacology

2021

DOI: 10.1016/j.jep.2020.113620

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Differentiation of Tarchonanthus camphoratus L. and Tarchonanthus parvicapitulatus P.P.J. Herman (Asteraceae) using electron microscopy, and comparison of their biological activities

A.O. Aro

Ibukun M. Famuyide

Ishaku Leo Elisha

et al.

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2022

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“…Thus the damaged filter part of the kidneys becomes 'leaky' and allows the protein along with the urine [1]. Loss of protein due to excessive damage of glomeruli results in a lower albumin levels in blood serum causing swelling all over the body (edema), resulting in the nephrotic syndrome [2,3]. Diabetic nephropathy is considered to the most common and one of the most serious issues in both types of diabetes mellitus and a most common cause of end stage renal disease (ESRD) across the globe [4].…”

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Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats

Chitra

Rini

Ramachandram

2022

J Diabetes Metab Disord

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Purpose This study was carried out to study the effect of anethole rich fraction on the Diabetic Nephropathy (DN) rats, and explore the mechanisms. Methods Male wistar rats were grouped into 4 (n = 6 per group): Control, junk food fed DN induced rats, low dose and high dose groups. DN was induced by oral junk food feeding. They were monitored for blood glucose levels and urine protein content at regular intervals. At the end of the study, the biological and hematological parameters were measured. Pancreatic and kidney viscera were taken to observe histopathological changes. Results Both the doses of anethole rich fraction could drastically lower blood glucose levels, Low Density Lipoprotein (LDL), Glycated Serum Protein (GSP), Total Cholesterol (TC), Triglycerides (TG) (P < 0.01), Malondialdehyde (MDA) level (P < 0.01 or P < 0.05), increases insulin level (P < 0.01), High Density Lipoproteins (HDL), Glutathione Reductase (GSH) and Superoxide Dismutase (SOD) (P < 0.01 or P < 0.05 or P > 0.05). Both doses of anethole rich fraction also improved the pathological changes of kidney and pancreatic tissues in DN rats (P < 0.01 or P < 0.05 or P > 0.05). Conclusions Hence it can be hypothesized that the high dose of anethole rich fraction (100 mg/kg) could reach the intervention effect and could ameliorate renal damage in DN rats by improving the renal functions, oxidative stress levels, glycometabolism and pathological changes of pancreas and kidney.

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mentioning

confidence: 99%

Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats

Chitra

Rini

Ramachandram

2022

J Diabetes Metab Disord

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Differentiation of Tarchonanthus camphoratus L. and Tarchonanthus parvicapitulatus P.P.J. Herman (Asteraceae) using electron microscopy, and comparison of their biological activities

Cited by 1 publication

References 51 publications

Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats

Renoprotective activity of anethole- rich fraction from aromatic herbs on junk food induced diabetic nephropathy in rats

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