Differentiation of rat skeletal muscle fibres during development and ageing

Punkt, Karla; Naupert, Andreas; Asmussen, G

doi:10.1016/j.acthis.2003.11.005

Cited by 51 publications

(52 citation statements)

References 22 publications

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“…As in most studies regarding age effects, the present results indicate a fast-to-slow fibre-type transition in soleus muscle, whereas no modification in fibre-type distribution was observed in EDL muscle (Smith et al, 1988;Ishihara and Taguchi, 1991;Sugiura et al, 1992;Konishi et al, 2000;Punkt et al, 2004).…”

Section: Discussionmentioning

confidence: 57%

“…Indeed, fibre-type differentiation does not take place to the same extent in the slow soleus muscle and the fast EDL muscle. For the soleus muscle, numerous authors reported a further increase in slow-twitch fibres to the detriment of fast-twitch fibres (Ishihara and Taguchi, 1991;Konishi et al, 2000;Punkt et al, 2004), whereas for the fast EDL muscle the fibre-type profile is already established (Smith et al, 1988;Sugiura et al, 1992;Yamaguchi et al, 1993;Punkt et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…an increase in type I fibres for the postural soleus muscle. Nevertheless, skeletal muscles are still submitted to some maturation process until adulthood (Ishihara and Taguchi, 1991;Punkt et al, 2004). During this post-weaning growth and maturation phase (week 4 to 16), the muscles continue to grow and mature until the animal reaches sexual maturity (Kovanen, 1989), in order to establish the final fibre-type profile.…”

Section: Introductionmentioning

confidence: 99%

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Differential adaptations during growth spurt and in young adult rat muscles

Barros

Manhães-de-Castro

Goubel

et al. 2009

Animal

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During the post-weaning growth and maturation period (25/90 days after birth), rat limb muscles are submitted to specific adaptations. Our aim was to characterize the mechanical properties of two muscles that are opposite in terms of fibre-type distribution, the soleus and the extensor digitorum longus (EDL) muscles of male Wistar rats. Results showed a fast-to-slow fibretype transition in soleus while no modification in fibre-type distribution was observed in EDL. A growth-induced increase in muscle force was observed. Soleus underwent an increase in twitch kinetics, but EDL showed no modification. Resistance to fatigue was higher in 90-day-old soleus but not modified in the EDL. Surprisingly, analysis of maximal shortening velocity showed a decrease in both soleus and EDL. Finally, tension/extension curves indicated a growth-induced increase in series elastic stiffness in the two muscles. These results suggest that during this growth period, skeletal muscles are submitted to differential adaptations. Moreover, whereas adaptation of biomechanical properties observed can be explained partly by an adaptation of fibre profile in soleus, this is not the case for EDL. It is suggested that changes in muscle architecture, which are often disregarded, could explain some variations in mechanical properties, especially when muscles undergo an increase in both mass and length.

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Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential adaptations during growth spurt and in young adult rat muscles

Barros

Manhães-de-Castro

Goubel

et al. 2009

Animal

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“…The structural makeup of skeletal muscle undergoes developmental changes towards the adult phenotype from birth. Respiratory muscles in rat undergo significant changes in fibre type profile during the first month of life [32,33]. KASS and BAZZY [20] found that the impairment of diaphragm muscle force following sustained hypoxia decreased with age.…”

Section: Discussionmentioning

confidence: 99%

Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development

Carberry

McMorrow

Bradford

et al. 2013

European Respiratory Journal

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Sustained hypoxia is a dominant feature of respiratory disease. Despite the clinical significance, the effects of sustained hypoxia on the form and function of respiratory muscle during development are relatively underexplored.Wistar rats were exposed to 1 week of sustained hypoxia (ambient pressure 450 mmHg) or normoxia at various time points during development. Sternohyoid and diaphragm muscle contractile and endurance properties were assessed in vitro. Muscle succinate dehydrogenase and myosin heavy chain composition were determined. The role of reactive oxygen species in hypoxia-induced muscle remodelling was assessed.Sustained hypoxia increased sternohyoid muscle force and fatigue in early but not late development, effects that persisted after return to normoxia. Hypoxia-induced sternohyoid muscle fatigue was not attributable to fibre type transitions or to a decrease in oxidative capacity. Chronic supplementation with the superoxide scavenger tempol did not prevent hypoxia-induced sternohyoid muscle fatigue, suggesting that mechanisms unrelated to oxidative stress underpin hypoxia-induced maladaptation in sternohyoid muscle. Sustained hypoxia had no effect on diaphragm muscle fatigue.We conclude that there are critical windows during development for hypoxia-induced airway dilator muscle maladaptation. Sustained hypoxia-induced impairment of upper airway muscle endurance may persist into later life. Upper airway muscle dysfunction could have deleterious consequences for the control of pharyngeal airway calibre in vivo. @ERSpublications There are critical windows during development for hypoxia-induced airway dilator muscle maladaptation

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“…The sections were analyzed, and images were acquired on a microscope (BZ-9000; Keyence, Osaka, Japan). Using the images from the serial sections stained for ATPase and SDH, the skeletal muscle fibers were categorized into types I, IIA, or IIB based on a previous study (21). The cross-sectional areas of skeletal muscle fibers were measured using ImageJ software (NIH, MD, USA).…”

Section: Body Weightmentioning

confidence: 99%

<b>Time course of ubiquitin-proteasome and macroautophagy-lysosome pathways in skeletal muscle in rats with heart failur</b><b>e </b>

et al. 2015

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Patients with heart failure have limited exercise capacity due to not only the myocardial dysfunction but also skeletal muscle atrophy. However, the mechanisms and time course of protein degradation in skeletal muscle during heart failure remain unclear, and there is no established standard treatment. The purpose of the present study was to investigate the time course of major protein degradation pathways in skeletal muscle during heart failure. Four-week-old male Wistar rats were randomly assigned to heart failure induced by monocrotaline or control groups. At 14 and 21 days after monocrotaline injection, the lungs, heart, and gastrocnemius and soleus muscles were removed and analyzed. There was no significant difference in body weight between the groups at 14 days after monocrotaline injection. Although there were no morphological changes in the skeletal muscle of the monocrotaline group at this time point, ubiquitin-proteasome and macroautophagylysosome pathways were activated in the monocrotaline group. Additionally, the pathways were less strongly activated in the soleus muscle than in the gastrocnemius muscle. These results suggest that physical exercise that shifts to slow muscle characteristics should begin when there is no indication of skeletal muscle atrophy to prevent exercise intolerance with heart failure.Patients with heart failure have limited exercise capacity due to not only myocardial dysfunction, but also skeletal muscle atrophy (6) and reduced strength (8). Skeletal muscle atrophy and consequent strength reduction result from various conditions such as muscular inactivity, sarcopenia, and cachexia, which decrease protein synthesis and increase protein degradation (17). Similarly, decreased protein synthesis (27) and increased protein degradation (4) after heart failure contribute to skeletal muscle atrophy, and protein degradation is especially common in chronic cases. Some protein degradation pathways involved in skeletal muscle atrophy, namely ubiquitin-proteasome and macroautophagy-lysosome pathways are delineated as major protein degradation system. Ubiquitinproteasome pathway activity is increased in atrophied

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Differentiation of rat skeletal muscle fibres during development and ageing

Cited by 51 publications

References 22 publications

Differential adaptations during growth spurt and in young adult rat muscles

Differential adaptations during growth spurt and in young adult rat muscles

Effects of sustained hypoxia on sternohyoid and diaphragm muscle during development

<b>Time course of ubiquitin-proteasome and macroautophagy-lysosome pathways in skeletal muscle in rats with heart failur</b><b>e </b>

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