Differentiation of qacA and qacB using high-resolution melt curve analysis, and both qacA and qacB but not qacC or norA types increase chlorhexidine minimal inhibitory concentrations in Staphylococcus aureus isolates

Lin, Kai-Hsiang; Lin, Chien‐Yu; Huang, Chieh-Chen; Ho, Yu‐Ling; Yang, Shufen; Ho, Cheng‐Maw

doi:10.1016/j.jmii.2020.09.006

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…Sequence analysis showed that the Tet38 protein is closely related to the TetA(K) tetracycline efflux pump, harbors 14 predicted transmembrane segments, and is a member of the MFS [82]. In addition to mediating resistance to tetracycline [83,84], tunicamycin [85], and Fosfomycin [86], Tet38 was demonstrated to transport fatty acids [87] and confer S. aureus internalization into host epithelial cells [88]. A more recent molecular analysis of Tet38 showed that various residues conferred differences in these functional characteristics [89].…”

Section: Tet38mentioning

confidence: 99%

The Major Facilitator Superfamily and Antimicrobial Resistance Efflux Pumps of the ESKAPEE Pathogen Staphylococcus aureus

et al. 2023

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The ESKAPEE bacterial pathogen Staphylococcus aureus has posed a serious public health concern for centuries. Throughout its evolutionary course, S. aureus has developed strains with resistance to antimicrobial agents. The bacterial pathogen has acquired multidrug resistance, causing, in many cases, untreatable infectious diseases and raising serious public safety and healthcare concerns. Amongst the various mechanisms for antimicrobial resistance, integral membrane proteins that serve as secondary active transporters from the major facilitator superfamily constitute a chief system of multidrug resistance. These MFS transporters actively export structurally different antimicrobial agents from the cells of S. aureus. This review article discusses the S. aureus-specific MFS multidrug efflux pump systems from a molecular mechanistic perspective, paying particular attention to structure–function relationships, modulation of antimicrobial resistance mediated by MFS drug efflux pumps, and direction for future investigation.

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