Differentiation of Pluripotent Stem Cells for Disease Modeling: Learning from Heart Development
Congwu Chi,
Truman J. Roland,
Kunhua Song
Abstract:Heart disease is a pressing public health problem and the leading cause of death worldwide. The heart is the first organ to gain function during embryogenesis in mammals. Heart development involves cell determination, expansion, migration, and crosstalk, which are orchestrated by numerous signaling pathways, such as the Wnt, TGF-β, IGF, and Retinoic acid signaling pathways. Human-induced pluripotent stem cell-based platforms are emerging as promising approaches for modeling heart disease in vitro. Understandin… Show more
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