Differentiation of osteophyte types in osteoarthritis – proposal of a histological classification

Junker, Susann; Krumbholz, Grit; Frommer, Klaus; Rehart, Stefan; Steinmeyer, Jürgen; Rickert, Markus; Schett, Georg; Müller‐Ladner, Ulf; Neumann, Elena

doi:10.1016/j.jbspin.2015.04.008

Cited by 22 publications

(33 citation statements)

References 12 publications

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“…On the mRNA level, it was found that osteophytes are composed of cells that express type I procollagen mRNA, mesenchymal prechondrocytes that express type IIA procollagen mRNA, and maturing chondrocytes that express type IIB procollagen mRNA [94]. On the protein level, Junker et al (2015) [95] found that collagen II was strongly expressed throughout osteophyte formation. Recently, several studies stated that COL2A1 mRNA expression level was significantly increased in chondrocytes isolated from articular cartilage of high-grade OA patients and proposed that this may be a compensatory anabolic response from the chondrocytes in attempts to restore the ECM [96,97].…”

Section: Discussionmentioning

confidence: 99%

COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model

et al. 2020

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Osteoarthritis (OA) is one of the most degenerative joint diseases in both human and veterinary medicine. The objective of the present study was the early diagnosis of OA in donkeys using a reliable grading of the disease based on clinical, chemical, and molecular alterations. OA was induced by intra-articular injection of 25 mg monoiodoacetate (MIA) as a single dose into the left radiocarpal joint of nine donkeys. Animals were clinically evaluated through the assessment of lameness score, radiographic, and ultrasonographic findings for seven months. Synovial fluid and cartilage samples were collected from both normal and diseased joints for the assessment of matrix metalloproteinases (MMPs) activity, COL2A1 protein expression level, and histopathological and immunohistochemical analysis of Caspase-3. Animals showed the highest lameness score post-induction after one week then decreased gradually with the progression of radiographical and ultrasonographic changes. MMP activity and COL2A1 and Caspase-3 expression increased, accompanied by articular cartilage degeneration and loss of proteoglycan. OA was successfully graded in Egyptian donkeys, with the promising use of COL2A1and Caspase-3 for prognosis. However, MMPs failed to discriminate between early and late grades of OA.

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Section: Discussionmentioning

confidence: 99%

COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model

et al. 2020

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“…20,21 It is not possible to manipulate the presence and severity of osteophytes with digital radiographic systems, and this fact suggests the potential advantage for use of a radiographic scoring system in evaluating mainly osteophytes. While the pathophysiology of osteophyte formation is not completely understood, 28 it is known that they occur early in the OA disease process, being consistent features of a destabilized stifle and representing a feature of disease progression that can be scored. 29 In assessment of OA progression, osteophytes can be observed early and prior to development of joint space narrowing.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Intra- and Inter-observer Measurement Variability of a Radiographic Stifle Osteoarthritis Scoring System in Dogs

Wessely¹,

Brühschwein²,

Schnabl‐Feichter³

2017

Vet Comp Orthop Traumatol

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To evaluate the intra- and inter-observer measurement variability of an existing osteoarthritis (OA) stifle scoring system. Paired caudocranial and mediolateral canine stifle radiographs were selected randomly. A total of 15 assessment points were evaluated independently and graded twice (integer numeric scale: 1-4) at an interval of 2 weeks by three observers with different levels of experience. The grades for each of the 15 factors were summed to obtain the OA score for each patient. The 15 independent assessment points measured by the three observers showed high reproducibility and low intra-observer variability. Inter-observer variability was also low (mean: 1.09 ± 4.99, 95% CI [confidence interval]: -0.35 to 2.55). The most discordant ratings among the three observers involved sesamoid bones of gastrocnemius muscle (assessment point 11 of 15) and popliteal surface of femur (assessment point 10 of 15). A validated and feasible OA scoring method is prerequisite for reliable radiographic assessment of OA progression. The low overall inter- and intra-observer variabilities among the 15 independent measures of the OA scoring system presented herein support its feasibility for application in clinical practice as an objective tool for radiographic scoring of stifle OA.

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“…Osteophytes are macroscopically sized bony outgrowths that can form on any bone surface but are prone to form within joint structures 1,2 . The formation of osteophytes is common and present in different joints e.g.…”

mentioning

confidence: 99%

Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes

Rabelo

Scheidt

Klebig

et al. 2020

Sci Rep

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Osteophytes -bony outgrowths on joint structures -are found in healthy individuals but are specifically present in late osteoarthritis (OA). Osteophyte development and function is not well understood, yet biomechanical stimuli are thought to be critical. Bone adapts to mechanical forces via the cellular network of osteocytes. The involvement of osteocytes in osteophyte formation and maturation has not been unravelled. Forty-three osteophytes from tibias of 23 OA patients (65 ± 9 years) were analysed. the trabecular bone structure of osteophytes presented with fewer trabeculae of lower bone mineral density compared to subchondral bone. We identified 40% early stage and 60% late stage osteophytes that significantly differed in their trabecular bone characteristics. Osteophyte bone revealed a higher number of osteocytes and a lower number of empty osteocyte lacunae per bone area than the subchondral bone. We found that OA osteophytes consist of younger bone material comprised of woven and lamellar bone with the capacity to develop into a late stage osteophyte potentially via the involvement of the osteocyte network. Our analysis of OA osteophytes implies a transition from woven to lamellar bone as in physiological bone growth within a pathological joint. Therefore, osteophyte development and growth present a valuable research subject when aiming to investigate the osteogenic signalling cascade.

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Differentiation of osteophyte types in osteoarthritis – proposal of a histological classification

Cited by 22 publications

References 12 publications

COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model

COL2A1 and Caspase-3 as Promising Biomarkers for Osteoarthritis Prognosis in an Equus asinus Model

Evaluation of Intra- and Inter-observer Measurement Variability of a Radiographic Stifle Osteoarthritis Scoring System in Dogs

Multiscale bone quality analysis in osteoarthritic knee joints reveal a role of the mechanosensory osteocyte network in osteophytes

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