Differentiation of Nevoid Basal Cell Carcinoma from Epithelioma Adenoides Cysticum

Graham, James H.; Mason, Judy; Gray, Howard R.; Helwig, Elson B.

doi:10.1038/jid.1965.34

Cited by 22 publications

(5 citation statements)

References 10 publications

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“…More in accordance with our results are those reported by Jackson & Gardere (1971), who in 102 tutnors found solid (69.97,), cystic (6.867,), adenoid (0.987o), superficial (10.787o), tnorphea-like (0.987>) and fibroepithelial (1.967o). Mason et al (1965) noticed the presence of bone or osteoid in 1 1 of 370 examined ttimors, and Graham et al (1965) reported bone in some of the cutaneous lesions of about one-third of the NBS-patients. Bone or osteoid in BCC was not seen at ail in the present study.…”

Section: Discussionmentioning

confidence: 98%

The nevoid basal cell carcinoma syndrome

Lindeberg

Jepsen

1983

J Cutan Pathol

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126 basal cell carcinomas from 7 patients with nevoid basal cell carcinoma syndrome were examined histologically and--using a scoring system--compared with 54 solitary basal cell carcinomas. The solid subtype formed 78.9% of all tumors in the head and neck region and 48.9% of those located elsewhere. A broader spectrum of histological subtypes was noticed in tumors from patients with the syndrome. As multiple, keratinizing odontogenic and epidermal cysts are often seen in the nevoid basal cell carcinoma syndrome it was interesting to see that multiple keratinizing cysts within skin tumors were recorded more often in this group.

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Section: Discussionmentioning

confidence: 98%

The nevoid basal cell carcinoma syndrome

Lindeberg

Jepsen

1983

J Cutan Pathol

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“…i Tbere is some evidence that the meso-' ; derm beneath nevoid basal cell carcinomas is similarly abnormal and in this way differs from other basal cell carcinomas. Tbe j nevoid tumors may be distinguisbed by tbe bigh composition of sulfated acid mucopolysaccbarides (Graham et al 1965) in the 1 underlying mesoderm and by a tendency • towards ossification and calcification in this tissue (Maddox et al 1964, Graham et al 1965, Murphy 1969. The basal proliferation | of tbese tumors is mimicked to some extent ' by tbe epithelium of odontogenic keratocysts.…”

Section: Odontogenic Keratocystsmentioning

confidence: 99%

The pathogenesis of odontogenic cysts: a review

Browne

1975

J Oral Pathology Medicine

138

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Abstract. The pathogenesis of the three common forms of odontogenic cyst is discussed. It is concluded that the dental cyst arises from proliferation of the epithelial rests of Malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. The dentigerous cyst arises from pooling of inflammatory exudate, which is derived from the obstructed follicular veins of an unerupted tooth and accumulates between the reduced enamel epithelium and the crown of the tooth. It enlarges by unicentric expansion from the hydrostatic pressure of its contents. The odontogenic keratocyst arises by proliferation of the residues of the dental lamina, possibly as a hamartomatous abnormality. It enlarges by both multicentric expansion due to the proliferation of localized groups of epithelial cells in the lining and by unicentric expansion from the hydrostatic pressure of its contents.

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“…Indeed about 35% show bone forma¬ tion whereas basal cell epitheliomas rarely do. 12 This, coupled with the reported radiologically demonstrable ectopic calcification in the falx cerebri, petroclinoid ligament, costal cartilage, and ovarian as well as mesenteric cysts serves as an identifying feature of the basal cell nevus syndrome.2 In at¬ tempting to discern the reason for the local depositions of calcium, evaluation of the function of the parathyroid gland by phos¬ phate excretion, and calcium infusion tests have regularly been normal,3 as they were in this patient. However, hyporesponsiveness to injected parathyroid hormone has been noted in some patients.13 This suggests that the defect is not in the parathyroid gland but in the local tissue response.…”

Section: Commentmentioning

confidence: 99%