Differentiation of multiple giant cell lesions, Noonan-like syndrome, and (occult) hyperparathyroidism

Neurofibromatosis presenting with a cherubism phenotype

“…But, multifocal lesions are very rare in patients with giant cell granulomas of the jaw [8] and do not involve the jaw bilaterally. Interestingly, of note is the well recognised association of NF1 and central giant-cell granuloma although when this occurs the giant cell granulomas are generally multiple and co-exist with extragnathic lesions [2,8,15,24,29]. In our case, hyperparathyroidism was ruled out on biochemicaland giant cell granulomas on clinical grounds.…”

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

“…Excluding the patient with neurofibromatosis-Noonan syndrome 41 , there have been 4 additional reports of multiple CGCGs in patients with NF1. 44,45,46,47 Molecular analysis of one of these cases 47 uncovered a novel Nf1 splice mutation in the proband, resulting in the deletion of 53 amino acids within the GTPase-activating domain of neurofibromin. Additional cases of a giant cell tumor of the occipital bone 48 and a patient with multiple "peripheral" giant cell granulomas 49 associated with extensive resorption of the underlying bone have also been reported.…”

Multifocal Central Giant Cell Granuloma of the Jaws: Case Report and Review of Literature

“…5,12,13 While the histologic features of CGCG are indistinguishable from these diseases, but and are different clinical and radiologic features. 2,5,14,15 They have differential diagnosis of multifocal CGCG must be made with these diseases.…”

“…Multifocal CGCGs are considered rare and strongly associated with several disorders. 5,12,13 In the present paper, we report a case of multifocal CGCG in an edentulous patient and review the literature reports on this case in the last 37 years that from 1977 to 2014.…”