Differentiation of mesothelial cells into macrophage phagocytic cells in a patient with clinical sepsis

Tirado, Mariantonieta; Koss, William

doi:10.1182/blood-2018-07-859991

Cited by 4 publications

(3 citation statements)

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“…Through a mechanism called transignaling, the local increase of IL-6Ra promotes an IL-6mediated neutrophil clearance subsequent to mononuclear cell recruitment (127,128). Apoptotic neutrophils are phagocytosed by MØs and to a lesser extent by the same MCs (129). Necrotic neutrophils and NETs promote the infiltration of mature MØs recruited also by locally produced chemokines such as CXCL8 and CCL2 (130).…”

Section: Leukocyte Recruitment During Peritonitis: From Neutrophils Tmentioning

confidence: 99%

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions

et al. 2021

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Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins leading to progressive thickening of the submesothelial compact zone of the peritoneal membrane. This process may be caused by a number of insults including pathological conditions linked to clinical practice, such as peritoneal dialysis, abdominal surgery, hemoperitoneum, and infectious peritonitis. All these events may cause acute/chronic inflammation and injury to the peritoneal membrane, which undergoes progressive fibrosis, angiogenesis, and vasculopathy. Among the cellular processes implicated in these peritoneal alterations is the generation of myofibroblasts from mesothelial cells and other cellular sources that are central in the induction of fibrosis and in the subsequent functional deterioration of the peritoneal membrane. Myofibroblast generation and activity is actually integrated in a complex network of extracellular signals generated by the various cellular types, including leukocytes, stably residing or recirculating along the peritoneal membrane. Here, the main extracellular factors and the cellular players are described with emphasis on the cross-talk between immune system and cells of the peritoneal stroma. The understanding of cellular and molecular mechanisms underlying fibrosis of the peritoneal membrane has both a basic and a translational relevance, since it may be useful for setup of therapies aimed at counteracting the deterioration as well as restoring the homeostasis of the peritoneal membrane.

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Section: Leukocyte Recruitment During Peritonitis: From Neutrophils Tmentioning

confidence: 99%

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions

et al. 2021

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“…The local increase of IL-6Rα promotes an IL-6-mediated neutrophil clearance after mononuclear cell recruitment through a mechanism called trans-signaling [ 42 , 43 ]. Apoptotic neutrophils are phagocytized by MØs and to a lesser extent by the same MCs [ 44 ]. Necrotic neutrophils and NETs promote the infiltration of mature MØs recruited also by locally produced chemokines, such as CXCL8 and CCL2 [ 45 ].…”

Section: Cellular and Molecular Mechanisms Implicated In The Damage O...mentioning

confidence: 99%

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

Trionfetti

Marchant

González-Mateo

et al. 2023

IJMS

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Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient KRT presenting benefices as home therapy. In PD patients, the peritoneum is chronically exposed to PD fluids containing supraphysiologic concentrations of glucose or other osmotic agents, leading to the activation of cellular and molecular processes of damage, including inflammation and fibrosis. Importantly, peritonitis episodes enhance peritoneum inflammation status and accelerate peritoneal injury. Here, we review the role of immune cells in the damage of the peritoneal membrane (PM) by repeated exposure to PD fluids during KRT as well as by bacterial or viral infections. We also discuss the anti-inflammatory properties of current clinical treatments of CKD patients in KRT and their potential effect on preserving PM integrity. Finally, given the current importance of coronavirus disease 2019 (COVID-19) disease, we also analyze here the implications of this disease in CKD and KRT.

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“…Also, as a result of mesothelial-to-mesenchymal transition (MMT), these cells, might be genetically reprogrammed after the influence of specific stimuli. In a recent mouse model, the lineage analysis of stem cells demonstrated that MMT increased the proliferation of myofibroblasts and hepatic satellite cells during liver fibrogenesis ( Tirado and Koss, 2018 ).…”

Section: Phases Of Normal Wound Healing and Fibrosismentioning

confidence: 99%

The Potential Use of Cannabis in Tissue Fibrosis

Pryimak

Zaiachuk

Kovalchuk

et al. 2021

Front. Cell Dev. Biol.

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Fibrosis is a condition characterized by thickening or/and scarring of various tissues. Fibrosis may develop in almost all tissues and organs, and it may be one of the leading causes of morbidity and mortality. It provokes excessive scarring that excels the usual wound healing response to trauma in numerous organs. Currently, very little can be done to prevent tissue fibrosis, and it is almost impossible to reverse it. Anti-inflammatory and immunosuppressive drugs are among the few treatments that may be efficient in preventing fibrosis. Numerous publications suggest that cannabinoids and extracts of Cannabis sativa have potent anti-inflammatory and anti-fibrogenic properties. In this review, we describe the types and mechanisms of fibrosis in various tissues and discuss various strategies for prevention and dealing with tissue fibrosis. We further introduce cannabinoids and their potential for the prevention and treatment of fibrosis, and therefore for extending healthy lifespan.

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Differentiation of mesothelial cells into macrophage phagocytic cells in a patient with clinical sepsis

Cited by 4 publications

References 0 publications

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions

Mechanisms of Peritoneal Fibrosis: Focus on Immune Cells–Peritoneal Stroma Interactions

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

The Potential Use of Cannabis in Tissue Fibrosis

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