Differentiation of malignant and benign breast lesions using magnetization transfer imaging and dynamic contrast‐enhanced MRI

Heller, Samantha L.; Moy, Linda; Lavianlivi, Sherlin; Moccaldi, Melanie; Kim, Sungheon

doi:10.1002/jmri.23786

Cited by 19 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Initial applications of MT-MRI in breast cancer showed a significant reduction of MTR in malignancies compared with benign lesions (11, 12). Bonini et al (11) hypothesized that increased proteolytic activity may cause a reduction of macromolecules in the malignant tumor environment, thus resulting in reduced MTR.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

et al. 2016

View full text Add to dashboard Cite

Quantitative magnetization transfer magnetic resonance imaging provides a means for indirectly detecting changes in the macromolecular content of tissue noninvasively. A potential application is the diagnosis and assessment of treatment response in breast cancer; however, before quantitative magnetization transfer imaging can be reliably used in such settings, the technique’s reproducibility in healthy breast tissue must be established. Thus, this study aims to establish the reproducibility of the measurement of the macromolecular-to-free water proton pool size ratio (PSR) in healthy fibroglandular (FG) breast tissue. Thirteen women with no history of breast disease were scanned twice within a single scanning session, with repositioning between scans. Eleven women had appreciable FG tissue for test–retest measurements. Mean PSR values for the FG tissue ranged from 9.5% to 16.7%. The absolute value of the difference between 2 mean PSR measurements for each volunteer ranged from 0.1% to 2.1%. The 95% confidence interval for the mean difference was ±0.75%, and the repeatability value was 2.39%. These results indicate that the expected measurement variability would be ±0.75% for a cohort of a similar size and would be ±2.39% for an individual, suggesting that future studies of change in PSR in patients with breast cancer are feasible.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Mammography has been shown to reduce breast cancer mortality in population-based screening programs however, it has well-recognized limitations, such as exposure to ionizing radiation and low sensitivity in patients with dense breasts [12].…”

Section: Discussionmentioning

confidence: 99%

“…The majority of benign lesions have a Type I curve, and the majority of malignant lesions have a Type III curve. Unfortunately there is overlap within these categories [12].…”

Section: Citationmentioning

confidence: 99%

“…The majority of benign lesions have a Type I curve, and the majority of malignant lesions have a Type III curve. Unfortunately there is overlap within these categories [12].We calculated the P value of each type of time signal intensity curve and we found that progressive (type I ) and the wash out (type III) curves were found in 5 (83.4%) and 0 (0%) pathologically proven benign lesions compared to 1 (16.6%) and 22 (100%) malignant lesions respectively. So their calculating P value was significant (<0.005) in differentiation benign from malignant lesions with progressive type curve more observed in benign findings and wash out curve more with malignant findings.…”

mentioning

confidence: 93%

“…It is generally accepted that early detection of breast cancer increases the probability of cure [10]. The objective of traditional diagnostic imaging examinations is to estimate the extent of disease and identify subclinical disease in the affected and contralateral breast to guide local therapy [11].Mammography has been shown to reduce breast cancer mortality in population-based screening programs however, it has well-recognized limitations, such as exposure to ionizing radiation and low sensitivity in patients with dense breasts [12].Ultrasonography has undergone significant improvements in the last years that have extended its utility for breast imaging. Important clinical advances in breast US have been the improved benign/malignant differentiation of solid breast lesions and the use of US to guide interventional procedures such as needle aspirations, core-needle biopsies, and pre-biopsy needle localizations of breast masses or calcifications.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Characterization of Suspicious Breast Lesions with Dynamic Contrast enhanced MRI In comparison to Conventional mammography and Ultrasonography

Ghazala¹

2016

JCPCR

View full text Add to dashboard Cite

This study included thirty three patients with suspicious breast lesions. For every patient; Mammography, Ultrasonography and Dynamic MRI were done.Our results indicate that the sensitivity of breast imaging can be increased by complementary use of MRI. For patients in whom the status of breast lesion remains unclear, MRI, though most expensive among all other complementary diagnostic modalities, it reduces the number of unnecessary biopsies and diagnostic challenges. Keywords: Mammography; Breast ultrasound; Dynamic MRI breast Characterization of Suspicious Breast Lesions with Dynamic Contrast enhanced MRI In comparison to Conventional mammography and Ultrasonography 2/19Copyright: ©2016 Ghazala et al. Citation MethodsMammography was conducted for all patients using digital mammography in both medio lateral oblique and craniocaudal views with spot compression magnification view when necessary.Mammographic images were analyzed regarding the presence of masses, architectural distortion, asymmetrical density and calcification. In detected masses their side, site, number, margins and density were evaluated, while in case of micro calcification their shape and distribution were assessed.Then classification of breast lesions was based on the Breast Imaging Reporting and Data System (BI-RADS).Then ultrasound was performed for all patients using a high frequency probe (7.5MHZ), scanning was done in two orthogonal (longitudinal and transverse) planes.Masses were evaluated by US considering BI-RADS US lexicon regarding: their shape, orientation, margins, echopattern (anechoic, hyperechoic, complex, hypoechoic, isoechoic), lesion boundary (abrupt interface, echogenic halo) and presence or absence of acoustic shadowing or enhancement.Then all patients were referred for further MRI examination. MR imaging protocolDynamic MR imaging was performed with high field strength 1.5 Tesla on (Philips Ingenia system) using dedicated double breast coil.Coronal T1 weighted spin echo sequence was carried out for localization purpose and followed by plain sequences using T1weighted fast spin echo sequence (TR=125msec.,TE= 5.3msec.),in addition to T2 weighted fast spin echo sequence (TR=3740mesc.,TE=90 msec.) in axial orientation.A bolus of gadolinium dimeglumine (Gd-DTPA) (Magnavist, Schering AG Berlin, Germany) was injected manually intravenous at a dose of (0.1mmol/kg) followed by saline flush to ensure that contrast -enhanced images could be obtained immediately after contrast agent injection.Dynamic T1 WIs then performed using Gradient echo T1 weighted image with fat suppression at the following time points: 1 minute, 2 min., 4 min. and 7 min.Post processing image subtraction was obtained between the post contrast imaging showing maximum enhancement and pre-contrast images (in the same axial plane), using the software subtraction function available on the work station.Quantitative analysis was done by placing the region of interest (ROI) at the most enhanced part within the lesion result in automatically created time/ signal...

show abstract

Separation of benign and malignant breast lesions using dynamic contrast enhanced MRI in a biopsy cohort

Kim

Freed

Leite

et al. 2016

Magnetic Resonance Imaging

Self Cite

View full text Add to dashboard Cite

PURPOSE To assess the diagnostic utility of contrast kinetic analysis for breast lesions and background parenchyma of women undergoing MRI-guided biopsies, for whom standard clinical analysis had failed to separate benign and malignant lesions. METHOD This study included 115 women who had indeterminate lesions based on routine diagnostic breast MRI exams and underwent an MRI(3T)-guided biopsy of one or more lesions suspicious for breast cancer. Breast DCE-MRI was performed using a radial stack-of-stars 3D spoiled gradient echo pulse sequence and modified k-space weighted image contrast (KWIC) image reconstruction. Contrast kinetic model analysis was conducted to characterize the contrast enhancement patterns measured in lesions and background parenchyma (BP). The transfer rate (Ktrans), interstitial volume fraction (ve), and vascular volume fraction (vp) estimated from the lesion and BP were used to separate malignant from benign lesions. RESULTS The patients with malignant lesions had significantly (p<0.05) higher median lesion-Ktrans (0.081 min−1), higher median BP-Ktrans (0.032 min−1), and BP-vp (0.020) than those without malignant lesions (0.056 min−1, 0.017 min−1 and 0.012, respectively). The area under the receiver operating characteristic curve (AUC) of the BP-Ktrans (0.687) was highest among the single parameters and higher than that of the lesion-Ktrans (0.664). The combined logistic regression model of lesion-Ktrans, lesion-ve, BP-Ktrans, BP-ve, and BP-vp had the highest AUC of 0.730. CONCLUSION Our results suggest that the contrast kinetic analysis of DCE-MRI data can be used to differentiate the malignant lesions from the benign and high-risk lesions among the indeterminate breast lesions recommended for MRI-guided biopsy exams.

show abstract

Differentiation of malignant and benign breast lesions using magnetization transfer imaging and dynamic contrast‐enhanced MRI

Cited by 19 publications

References 35 publications

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

Quantitative Magnetization Transfer Imaging of the Breast at 3.0 T: Reproducibility in Healthy Volunteers

Characterization of Suspicious Breast Lesions with Dynamic Contrast enhanced MRI In comparison to Conventional mammography and Ultrasonography

Separation of benign and malignant breast lesions using dynamic contrast enhanced MRI in a biopsy cohort

Contact Info

Product

Resources

About