Abstract:The rate of the spontaneous activity of cultured cells from the chick embryonic ventricle was only slightly increased by norepinephrine (NE) or epinephrine (EP), even if it was applied close to the cell. On the other hand, the amplitude of contraction, measured from the shortening of the diameter of the cell aggregate, was clearly augmented by up to 50%. Intracellularly injected cAMP also potentiated contraction. Namely, NE, EP, or CAMP showed positive inotropic action but slight Chronotropic action on culture… Show more
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