Differentiation of human olfactory mucosa mesenchymal stem cells into photoreceptor cells in vitro

Lu, Wen; Duan, Da; Ackbarkhan, Zacharia; Lu, Ming; Huang, Manni

doi:10.18240/ijo.2017.10.04

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Within the olfactory system, these cells can play a reparative role after extensive peripheral damage, as they are able to cross the basement membrane in order to differentiate into neurons and replace the olfactory epithelium if necessary [ 33 ], in addition to their previously demonstrated capacity to promote myelination [ 37 ]. Some groups have differentiated OE-MSCs into different lineages [ 38 , 39 ] and have even shown their regenerative properties in several models of neurodegenerative disorders such as Parkinson´s disease [ 40 ] or spinal cord injury [ 41 ]. Recently, OE-MSCs were differentiated into dopaminergic neurons [ 42 ] and motor neuron-like cells [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich’s Ataxia Patients

Pérez-Luz

Loría

Katsu-Jiménez

et al. 2020

IJMS

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Friedreich’s ataxia is the most common hereditary ataxia for which there is no cure or approved treatment at present. However, therapeutic developments based on the understanding of pathological mechanisms underlying the disease have advanced considerably, with the implementation of cellular models that mimic the disease playing a crucial role. Human olfactory ecto-mesenchymal stem cells represent a novel model that could prove useful due to their accessibility and neurogenic capacity. Here, we isolated and cultured these stem cells from Friedreich´s ataxia patients and healthy donors, characterizing their phenotype and describing disease-specific features such as reduced cell viability, impaired aconitase activity, increased ROS production and the release of cytokines involved in neuroinflammation. Importantly, we observed a positive effect on patient-derived cells, when frataxin levels were restored, confirming the utility of this in vitro model to study the disease. This model will improve our understanding of Friedreich´s ataxia pathogenesis and will help in developing rationally designed therapeutic strategies.

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Section: Introductionmentioning

confidence: 99%

Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich’s Ataxia Patients

Pérez-Luz

Loría

Katsu-Jiménez

et al. 2020

IJMS

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Ocular stem cells: a narrative review of current clinical trials

Sotiropulos¹,

Almaliotis²,

Ploumidou³

et al. 2022

Int J Ophthalmol

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Stem cells are undifferentiated cells showcasing a remarkable capacity of self-replenishing and differentiating into mature cells. Their ability to proliferate connotes that a designated stem cell source is capable of generating an unrestricted number of mature cells. The ever-increasing comprehension of position, activity, and function of ocular stem cells has led to rapid progress and incessant improvement of possible procedures and therapies. A narrative review was conducted to summarize the current evidence on clinical trials and respective literature, regarding current evolution in the field of ocular regenerative medicine. We tried to ascertain the safety of experimental and clinical procedures, their effectiveness, and the ethical repercussion of their use.

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Differentiation of human olfactory mucosa mesenchymal stem cells into photoreceptor cells in vitro

Abstract: This novel finding demonstrates that OM-MSCs can be cultured and expanded . They possess biological characteristics of mesenchymal stem cells, and have the ability to be induced into retinal cells.

Cited by 2 publications

References 20 publications

Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich’s Ataxia Patients

Altered Secretome and ROS Production in Olfactory Mucosa Stem Cells Derived from Friedreich’s Ataxia Patients

Ocular stem cells: a narrative review of current clinical trials

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