Differentiation of focal nodular hyperplasia from hepatocellular adenomas with low-mecanical-index contrast-enhanced sonography (CEUS): effect of size on diagnostic confidence

Abstract

• CEUS is highly specific for the diagnosis of FNH, regardless of lesion size • CEUS shows reduced sensitivity in diagnosing FNH lesions larger than 35 mm • The filling patterns of hepatocellular adenomas are not affected by lesion size.

Improvement of the accuracy of liver lesion DCEUS quantification with the use of automatic respiratory gating

“…Although this study evaluates the use of ARG on DCEUS quantification, qualitative evaluation of image loops [20] may also benefit from such a motion-correction technique. By applying ARG on image loops during review, the removal of out-of-plane motion results in a more accurate depiction of the area.…”

Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?

“…CEUS findings of HCA were described in previous studies [5][6][7][8]18] . In one study which investigated 18 lesions, which were iso-hypoechoic in 9, hyper-enhancing in all in the arterial phase, and iso or hypo-enhancement in all in the late phase [18] .…”

“…Although contrast-enhanced ultrasonographic features of HCA have been reported in several literatures till now [5][6][7] , there have been little studies that described those of each type of HCA [8] . HCAs usually arise in the liver without steatosis, because a nodule arising in fibrotic/cirrhotic liver was not to be a HCA according to World Health Organization classification 2010 [1] .…”

Romanian National Guidelines on Contrast Enhanced Ultrasound in clinical practice

“…In the STIC study, CEUS had 82.5% sensitivity and 94.3% specificity for the diagnosis of FNH [22], while in the DEGUM study they were 57.1% and 99.3%, respectively [18]. The calculated pooled sensitivity for FNH was 88% in the Frie-drich-Rust meta-analysis [10] and the specificity can go as high as 100% [12,23]. Adenoma is a rare benign liver tumor, more frequent in young women and in people using steroid containing drugs [24].…”