Differentiation of focal indeterminate marrow abnormalities with multiparametric MRI

Abstract

3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:49-60.

Solid bone tumors of the spine: Diagnostic performance of apparent diffusion coefficient measured using diffusion‐weighted MRI using histology as a reference standard

“…It is more and more applied in oncologic imaging, apparent diffusion coefficient (ADC) being a parameter used to measure the magnitude of diffusion of water molecules within biologic tissues . Previous studies investigated the role of DWI in the differentiation between benign and malignant skeletal conditions, with promising results . However, studies performed in the spine had small sample size or lacked histology comparison .…”

“…8 Previous studies investigated the role of DWI in the differentiation between benign and malignant skeletal conditions, with promising results. [9][10][11][12][13][14][15][16][17][18][19] However, studies performed in the spine had small sample size or lacked histology comparison. 11,12,14,16,19 Moreover, several of these studies focused on the differentiation between osteoporotic and malignant vertebral fractures, in which ADC measurement is affected by bone marrow edema related to compression fracture itself.…”

Measurements of Diffusion and Perfusion in Vertebral Bone Marrow Using Intravoxel Incoherent Motion (IVIM) With Multishot, Readout‐Segmented (RESOLVE) Echo‐Planar Imaging

“…In previous IVIM studies on vertebral bone marrow, single-shot EPI sequences have been employed. [3][4][5][6][7][8][9] In the current study the use of a RESOLVE sequence (ie, a segmented readout) allows for 1) an increase of the matrix size, thus the acquisition of images with an improved spatial resolution and 2) the shortening of the EPI echo train, which contributes to reduce the distortions and blurring artifacts on the images. The disadvantage of the RESOLVE sequence, in comparison to the single-shot approach, is the longer acquisition time.…”

“…As a result, the IVIM technique can now be applied to various tissues. Surprisingly, however, only a very limited number of IVIM studies have been performed on bone marrow . This might be due to lipids, which represent a major confounding factor in the quantification of both diffusion and perfusion .…”

“…Surprisingly, however, only a very limited number of IVIM studies have been performed on bone marrow. [3][4][5][6][7][8][9] This might be due to lipids, which represent a major confounding factor in the quantification of both diffusion and perfusion. 10,11 While the effects of the lipids on the quantification of the water (apparent) diffusion coefficient (ADC) in bone marrow have been investigated, 12 little attention has been paid to their effects on the diffusion (D, D*) and perfusion (f ) parameters obtained by the IVIM approach.…”