Differentiation of Compressive from Glaucomatous Optic Neuropathy with Spectral-Domain Optical Coherence Tomography

Comparison of the Pattern of Retinal Ganglion Cell Damage Between Patients With Compressive and Glaucomatous Optic Neuropathies

“…Intraocular pressure was lower in the GON group than the healthy control group, which is attributable to many of the patients being on IOP-lowering treatment at the time of SD-OCT. Interestingly, IOP was also lower in the CON group than in the control group, which is consistent with the findings of Danesh-Meyer et al 16 Although we do not have a clear explanation for this finding, we speculate that it is related to the effect of long-term hormonal imbalance in CON patients who have a parasellar tumor. It is known that the production of the aqueous humor is influenced by pituitary hormones.…”

“…1), which is consistent with previous findings. 16,19,[30][31][32] The nasal and temporal cpRNFL thinning is consistent with the classic band atrophy of the ONH that can be seen in patients with a chiasmal tumor and preservation of uncrossed fibers. 16 On the other hand, the cpRNFL showed thinning in all sectors except for the T and NS sectors in GON, with the thinning being most notable in the TS and TI sectors (Fig.…”

“…Data obtained at least 6 months after intracranial surgery were used for analysis, because the VF loss associated with CON may not be the result of RGC loss but instead result from RGC dysfunction and so be reversible after performing decompressing surgery. 16 Only subjects without any evidence of recurrent tumor confirmed by neuroradiologic examinations and with stable VF defects for at least 6 months were included. Patients with an intraocular pressure (IOP) greater than 21 mm Hg or definite glaucomatous optic nerve damage (neuroretinal rim notching, thinning, or localized retinal nerve fiber layer [RNFL] defect) in either eye were excluded from this study.…”

“…16 They found that the cpRNFL profile differed distinctively between the two diseases, with the damage occurring predominantly in the temporal and nasal sectors of the optic nerve head (ONH) in CON, but in the superior and inferior sectors in GON.…”

“…Danesh-Meyer et al 16 showed that evaluating the circumpapillary retinal nerve fiber layer (cpRNFL) thickness using optical coherence tomography (OCT) can distinguish the differing patterns of retinal ganglion cell (RGC) damage between CON and GON. 16 They found that the cpRNFL profile differed distinctively between the two diseases, with the damage occurring predominantly in the temporal and nasal sectors of the optic nerve head (ONH) in CON, but in the superior and inferior sectors in GON.…”