Differentiation of benign and malignant cervical lymph nodes: Value of B-mode and color Doppler sonography

Adıbelli, Zehra Hilal; Ünal, Gökhan; Erdal, Gül; Uslu, Figen; Koçak, Ümit; Abali, Yusuf

doi:10.1016/s0720-048x(97)00174-5

Cited by 55 publications

(40 citation statements)

References 18 publications

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“…The role of Doppler US in the assessment of vasculature of cervical lymph nodes using CDS and PDS (Na et al 1997;Adibelli et al 1998;Ariji et al 1998;Steinkamp et al 1998;Tschammler et al 1998;Wu et al 1998b;Dragoni et al 1999;Ying 2002;Ying 2003a, 2003b;Ying and Ahuja 2003) is well established. Comparison of the findings of CDS and PDS has been Fig.…”

Section: Discussionmentioning

confidence: 99%

“…With the availability of colour Doppler sonography (CDS) and power Doppler sonography (PDS), the intranodal vasculature of cervical lymph nodes can now be evaluated (Adibelli et al 1998;Steinkamp et al 1998;Wu et al 1998a;Ahuja et al 2001b). It is generally believed that PDS has a higher sensitivity than CDS in the detection of intranodal vasculature (Bude et al 1994;Choi et al 1996; Barth and Shortliffe 1997;Bartolozzi et al 1997;Wright et al 1998).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of cervical lymph node vascularity: A comparison of colour Doppler, power Doppler and 3-D power Doppler sonography

Ahuja

Ying

2004

Ultrasound in Medicine & Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of cervical lymph node vascularity: A comparison of colour Doppler, power Doppler and 3-D power Doppler sonography

Ahuja

Ying

2004

Ultrasound in Medicine & Biology

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“…Our experience with sonographically suspicious or highly suspicious lymph nodes shows that EIS achieves a high overall detection rate of 96.9% -but with a poor true negative outcome of only 45.2%. We judge the value of detectability to be promising, particularly in light of the fact that the published sensitivity and specificity values of sonographic examinations, including colour Doppler ultrasound, range between 66.0-92.8% and 60.0-80.0%, respectively, depending on the study inclusion criteria and the experience of the clinician examining on lymph nodes [23,24,25,26]. It must be addressed that reported accuracy using fine-needle aspiration cytology is currently higher than the corresponding value using EIS [10,13].…”

Section: Discussionmentioning

confidence: 99%

Use of electrical impedance scanning in the differentiation of sonographically suspicious and highly suspicious lymph nodes of the head–neck region

et al. 2002

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Sonographic differentiation between inflammatory and malignant lymph nodes is difficult, due in part to almost unchanged morphology of small lymph node metastases; however, as cancer cells exhibit altered dielectric properties, measurement of local electrical field distortions may be useful as adjunct to ultrasound in detection of malignancy. In this study, we evaluated the ability of electrical impedance scanning (EIS) to differentiate cervically located sonographically suspicious or highly suspicious lymph nodes. Seventy patients with 106 sonographically suspicious lymph nodes (mean size 20 x 13 x 13 mm, mean depth 8 mm) were examined using TransScan TS2000 (Siemens, Erlangen, Germany; manufactured by TransScan Research and Development Co., Israel). Included in the study were cervical ( n=64), inframandibular/periparotideal ( n=32) and nuchal/supraclavicular ( n=10) nodes. The EIS results were compared with histopathological ( n=100) and serological ( n=6) findings. Sixty-two of 64 malignant lymph nodes were correctly detected using EIS; 19 of 42 inflammatory/benign lymph nodes were correctly identified as benign (true positive 96.9%, true negative 45.2%; accuracy 71.3%, negative predictive value 90.5%, positive predictive value 59.6%). The high tumour detection rate achieved in this study suggests that EIS may be of value as an adjunctive technique in differentiation of lymph nodes of the head-neck region. Software changes to reduce the high number of false-positive markers are, however, necessary to improve the value in the evaluation during a regular clinical routine.

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“…Previously, several gray-scale and power Doppler sonographic features were used to differentiate between benign and malignant cervical nodes. [1][2][3][4][5][6] However, the interpretation of sonograms of lymph nodes is subject to variability 7,8 due to variable clinical practice and/or levels of experience.…”

Section: Introductionmentioning

confidence: 99%

Application of Computer-Aided Diagnosis to the Sonographic Evaluation of Cervical Lymph Nodes

Zhang

Wang

et al. 2015

Ultrason Imaging

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We initiated an observer study to evaluate a computerized system developed in our previous study for automatic extraction of 10 features and estimation of the malignancy probability of cervical nodes in sonograms. In the present study, five expert radiologists and five resident radiologists interpreted the sonograms of 178 nodes. The malignancy rating and patient management recommendation (biopsy or follow-up) were made without and then with the computer aid. Under these two reading conditions, the performances of radiologists and agreement among a group of radiologists were evaluated by using the receiver operating characteristic (ROC) analysis and the κ statistic, respectively. With the computer aid, the performances of radiologists improved significantly, as indicated by the increase in the area under the ROC curve (Az) from 0.843 to 0.896 (p = 0.031) and from 0.705 to 0.822 (p < 0.001), for the expert and resident groups, respectively. Agreement among all 10 radiologists improved from slight to moderate as indicated by an increase in the κ value from 0.195 to 0.421 (p < 0.001). The average performance of residents with aid (Az = 0.822) was close to that of experts without aid (Az = 0.843). Results indicate that computer-aided diagnosis is useful to improve radiologist performance (especially that of inexperienced radiologists) in the ultrasonographic evaluation of cervical nodes and to reduce variability among radiologists.

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Differentiation of benign and malignant cervical lymph nodes: Value of B-mode and color Doppler sonography

Cited by 55 publications

References 18 publications

Evaluation of cervical lymph node vascularity: A comparison of colour Doppler, power Doppler and 3-D power Doppler sonography

Evaluation of cervical lymph node vascularity: A comparison of colour Doppler, power Doppler and 3-D power Doppler sonography

Use of electrical impedance scanning in the differentiation of sonographically suspicious and highly suspicious lymph nodes of the head–neck region

Application of Computer-Aided Diagnosis to the Sonographic Evaluation of Cervical Lymph Nodes

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