Differentiation of atypical hepatic hemangioma from liver metastases: Diagnostic performance of a novel type of color contrast enhanced ultrasound

Wu, Xuefeng; Bai, Xiu-Mei; Yang, Wei; Sun, Yu; Wang, Hong; Wu, Wei; Chen, Minhua; Yan, Kun

doi:10.3748/wjg.v26.i9.960

Cited by 23 publications

(26 citation statements)

References 30 publications

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“…The diagnostic accuracy of MRI with liver-specific contrast agents is significantly higher than that of CEUS [ 9 ]. Wu et al reported an association between RE representing hepatic uptake of Gd-EOB-DTPA and the METAVIR scoring system used to differentiate normal liver parenchyma from higher stages of hepatic fibrosis [ 10 ]. Bai et al demonstrate that high intensity on DWI, coupled with high signal intensity on T2, is the most specific feature to distinguish atypical HCC from dysplastic nodules (sensitivity 80.0%, specificity 100%, positive predictive value 100%, and negative predictive value 78.3%).…”

Section: Literature Reviewmentioning

confidence: 99%

[Retracted] The Value of Nuclear Magnetic Resonance in Liver Nodular Lesions

Chen

Bao

2022

Contrast Media & Molecular Imaging

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In order to analyze the value of contrast-enhanced ultrasound (CEUS) combined with functional magnetic resonance imaging (fMRI) in the early differential diagnosis of liver nodular lesions, the authors studied the value of MRI in liver nodular lesions. A total of 82 patients with liver nodular lesions admitted to the hospital were selected for retrospective analysis; all of them underwent CEUS and fMRI examinations, and taking a biopsy or postoperative pathological examination results as the gold standard, the diagnostic value of CEUS, fMRI single item, and the two combined examinations for liver nodular lesions was analyzed by four-table. The biopsy or postoperative pathological examination results showed that a total of 88 lesions were detected in 82 patients, including 51 patients with benign lesions, with 54 lesions, and 31 patients with malignant lesions, with 34 lesions. Taking biopsy or pathological examination results as the gold standard, the four-table analysis CEUS had a sensitivity of 79.63%, a specificity of 82.35%, an accuracy of 80.68%, and a Kappa value of 0.603 for diagnosing benign and malignant liver nodular lesions. The sensitivity of fMRI in diagnosing benign and malignant liver nodular lesions was 83.33%, the specificity was 85.29%, the accuracy was 84.09%, and the Kappa value was 0.672; the combined sensitivity of the two in the diagnosis of benign and malignant liver nodular lesions was 94.44%, the specificity was 91.18%, the accuracy was 93.18%, and the Kappa value was 0.856, both of which were superior to single detection, and the difference in accuracy was statistically significant ( χ 2 = 5.683, P < 0.05 ). CEUS and fMRI have a certain value in the differential diagnosis of liver nodular lesions; the combination of the two can improve the diagnostic sensitivity and accuracy, and has more clinical application value.

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Section: Literature Reviewmentioning

confidence: 99%

[Retracted] The Value of Nuclear Magnetic Resonance in Liver Nodular Lesions

Chen

Bao

2022

Contrast Media & Molecular Imaging

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“…The contrast agents washed out very rapidly during the portal phase and presented hypo-enhancement until the end of the late phase. Wu et al [ 28 ] showed that metastatic lesion presented non-enhancement during the late phase. Zhang et al [ 29 ] found that lung primary lesion’s MLC showed no significant enhancement in CEUS, which was contrary to other findings.…”

Section: Discussionmentioning

confidence: 99%

High-frame-rate contrast-enhanced ultrasound findings of liver metastasis of duodenal gastrointestinal stromal tumor: A case report and literature review

Chen¹,

Huang²

2022

WJCC

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BACKGROUND Liver metastasis of duodenal gastrointestinal stromal tumor (GIST) is rare. Most reports mainly focus on its treatment and approaches to surgical resection, while details on its contrast-enhanced ultrasound (CEUS) findings are lacking. The diagnosis and imaging modalities for this condition remain challenging. CASE SUMMARY A 53-year-old Chinese man presented with mild signs and symptoms of the digestive tract. He underwent routine examinations after GIST surgery. Magnetic resonance imaging showed a 2.3 cm hepatic space-occupying lesion. All the laboratory test results were within normal limits. For further diagnostic confirmation, we conducted high frame rate CEUS (H-CEUS) and found a malignant perfusion pattern. Heterogeneous concentric hyper-enhancement, earlier wash-in than the liver parenchyma, and two irregular vessel columns could be observed at the periphery of the lesion during the arterial phase. Ultrasound-guided puncture biopsy was used to confirm the diagnosis of the lesion as liver metastasis of duodenal GIST. Imatinib was prescribed after biopsy, and the patient’s clinical course was monitored. CONCLUSION H-CEUS is useful for detecting microcirculation differences, wash-in patterns, and vascular morphogenesis and diagnosing liver metastasis of duodenal GIST.

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“…Yang (15) once succeeded in diagnosing a case of thyroid haemangioma with CEUS preoperatively, and believed that the "slow in and slow out" pattern of contrast filling and perfusion was the characteristic feature of haemangioma. Wu (16) summarized the typical features of liver haemangioma as peripheral nodular and centripetal enhancement during the arterial phase followed by hyperor isoenhancement during the portal venous and late phases on CEUS. MRI, especially enhanced MRI can also provide valuable diagnostic information for haemangioma before surgery (1)(2)(3)17).…”

Section: Discussionmentioning

confidence: 99%

Arteriovenous haemangioma of the vas deferens: a case report and literature review

et al. 2021

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Arteriovenous haemangioma of the vas deferens is an extremely rare entity in clinical practice.To date, there have been no clinical or pathological cases reported in Medline, Embase or other published English literature. Herein, a 50-year-old male who presented with right scrotal pain for 4 years after vasectomy was admitted to our hospital. One painful nodule was palpable in the right scrotum on physical examination. Color Doppler ultrasound merely showed dilation of the epididymis and no additional information concerning the painful nodule in the right scrotum. Moreover, the laboratory test results were all within normal limits. Ibuprofen was administered to the patient for 2 months with a poor effect, and then spermatic cord block significantly relieved his symptoms. This patient underwent resection of the right painful nodule of the vas deferens under medical advice. Postoperative pathological examinations showed arteriovenous haemangioma of the vas deferens. There were no obvious complications after arteriovenous haemangioma excision, and the right scrotal pain was significantly relieved 1 month later. This article reminds urologists and oncologists that haemangioma can involve the vas deferens and, in addition to spermatic granuloma, might be a cause of post-vasectomy pain syndrome. Cauterization of the vas deferens might have a potential relationship with haemangioma.

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Differentiation of atypical hepatic hemangioma from liver metastases: Diagnostic performance of a novel type of color contrast enhanced ultrasound

Abstract: conceived and designed the study, performed the examinations, and the data analysis; Sun Y performed the pathologic analysis. Wu XF and Bai XM contributed equally to this work.

Cited by 23 publications

References 30 publications

[Retracted] The Value of Nuclear Magnetic Resonance in Liver Nodular Lesions

[Retracted] The Value of Nuclear Magnetic Resonance in Liver Nodular Lesions

High-frame-rate contrast-enhanced ultrasound findings of liver metastasis of duodenal gastrointestinal stromal tumor: A case report and literature review

Arteriovenous haemangioma of the vas deferens: a case report and literature review

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