Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI

Li, Jingjing; Xue, Ming; Lv, Zhi; Guan, Chunshuang; Huang, Shibo; Li, Shuo; Liang, Bo; Zhou, Xingang; Chen, Budong; Xie, Ruming

doi:10.1016/j.ijid.2021.10.023

International Journal of Infectious Diseases

2021

DOI: 10.1016/j.ijid.2021.10.023

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Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI

Jingjing Li

Ming Xue

Zhi Lv

et al.

Abstract: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, a… Show more

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2024

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Cited by 2 publications

References 37 publications

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Clinicopathological analysis of primary central nervous system lymphoma in patients with or without AIDS

Li,

Chen,

Feng

et al. 2024

Preprint

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Background AIDS-related primary central nervous system lymphoma (AR-PCNSL) differs from immunocompetent-primary central nervous system lymphoma (IC-PCNSL) in certain features. The main objective of this study was to investigate the differences in clinicopathological features between AR-PCNSL and IC-PCNSL. Methods Thirty-seven AR-PCNSL patients and thirty IC-PCNSL patients were included. hematoxylin & eosin staining; immunohistochemical detection using CD20, Bcl-2, Bcl-6, p53, C-MYC, Ki67, and METTL3 antibodies; and Epstein–Barr encoding region (EBER) in situ hybridization were performed. Results All of the observed patients were classified as the DLBCL histological type. AR-PCNSL were younger (37.7 vs. 60.5 years) and had a higher likelihood of being male (86.5% vs. 63.3%) than non-AIDS patients were. Elevated LDH and low sugar content in cerebrospinal fluid (CSF) were more common among AR-PCNSL. The expression levels of METTL3, Bcl-2 and p53 expressions were significantly higher in AR-PCNSL patients than in PCNSL patients without AIDS. In contrast, AR-PCNSL patients exhibited lower levels of Bcl-6 expression. AR-PCNSL patients were more likely to be positive for EBER, accounting for 81.1% of these patients. Furthermore, we also found that the expression of METTL3 was lower in GCB-like DLBCL (n=7) than in ABC-like DLBCL (n=32) in AR-PCNSL (p=0.041); however, in IC-PCNSL patients, the expression of METTL3 was not significantly different between GCB-like DLBCL and ABC-like DLBCL (p=0.710). Conclusions Our study of Chinese AR-PCNSL and IC-PCNSL patients revealed new findings, indicating that METTL3, Bcl-2 and p53 were increased in AR-PCNSL patients compared to IC-PCNSL patients and that METTL3 was higher in ABC-like DLBCL patients than in GCB-like DLBCL in AR-PCNSL patients, suggesting a notable distinction in the pathological characteristics between PCNSL patients with or without AIDS.

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Clinicopathological analysis of primary central nervous system lymphoma in patients with or without AIDS

Li,

Chen,

Feng

et al. 2024

Preprint

View full text Add to dashboard Cite

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Clinicopathological analysis of primary central nervous system lymphoma in patients with or without HIV infection

Li,

Chen,

Feng

et al. 2024

Preprint

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Background The main aim of this study was to investigate the differences in clinicopathological features between HIV-related primary central nervous system lymphoma (PCNSL) and immunocompetent-primary central nervous system lymphoma (IC-PCNSL). Methods The study included thirty-seven patients with HIV-related PCNSL and thirty patients with IC-PCNSL. Hematoxylin & eosin (HE) staining, immunohistochemical detection using CD20, Bcl-2, Bcl-6, p53, C-MYC, Ki67, methyltransferase like factor 3 (METTL3) antibodies, and Epstein–Barr encoding region (EBER) in situ hybridization were performed. Results All of the patients were classified as the diffuse large B-cell lymphoma (DLBCL) histological type. Patients with HIV-related PCNSL were younger and more likely to be male compared to patients with IC-PCNSL. Elevated lactate dehydrogenase (LDH) and low sugar content in cerebrospinal fluid (CSF) were more common among HIV-related PCNSL. The expression levels of METTL3, Bcl-2 and p53 were significantly higher in HIV-related PCNSL patients than in IC-PCNSL patients. In contrast, HIV-related PCNSL patients exhibited lower levels of Bcl-6 expression and more likely to be positive for EBER, accounting for 81.1% of these patients. Furthermore, we also found that the expression of METTL3 was lower in germinal center B (GCB)-like DLBCL (n = 7) than in activated B-cell (ABC)-like DLBCL (n = 32) in HIV-related PCNSL (p = 0.041); however, in IC-PCNSL patients, the expression of METTL3 was not significantly different between GCB-like DLBCL and ABC-like DLBCL (p = 0.710). Conclusion Our study of Chinese patients with HIV-related PCNSL and IC-PCNSL has revealed new findings: although the tumor manifestations are similar in PCNSL patients with and without HIV, HIV-related PCNSL differs from IC-PCNSL in terms of pathological characteristics including METTL3, Bcl-2, p53, Bcl-6, and EBER. We therefore suggest that the pathogenesis of HIV-related PCNSL and IC-PCNSL may be different due to host's immune status.

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Differentiation of Acquired Immune Deficiency Syndrome Related Primary Central Nervous System Lymphoma from Cerebral toxoplasmosis with Use of Susceptibility-Weighted Imaging and Contrast Enhanced 3D-T1WI

Cited by 2 publications

References 37 publications

Clinicopathological analysis of primary central nervous system lymphoma in patients with or without AIDS

Clinicopathological analysis of primary central nervous system lymphoma in patients with or without AIDS

Clinicopathological analysis of primary central nervous system lymphoma in patients with or without HIV infection

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