2018
DOI: 10.1002/jmri.25939
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Differentiation between vasogenic edema and infiltrative tumor in patients with high‐grade gliomas using texture patch‐based analysis

Abstract: 1 Technical Efficacy Stage 4 J. Magn. Reson. Imaging 2018.

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Cited by 37 publications
(29 citation statements)
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References 37 publications
(49 reference statements)
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“…The finding of elevated absolute qT1‐difference values in the edema region stands in line with the results of several previous MRI and MRS studies that also show changes for different MR parameters beyond the enhancing part of glioblastomas: a stripe‐like pattern of regional CBV increase was found in a defined region adjacent to the contrast‐enhancing tumor, which then transformed into enhancing tumor tissue in the follow‐up; the VOI analysis of BOLD‐based relative oxygen extraction fraction (rOEF) maps revealed potentially hypoxic tumor regions with high rOEF in the nonenhancing infiltration zone; peritumoral fiber structures showed significant decreases of N‐acetyl‐aspartate concentrations and fiber densities when compared with the contralateral side . Further studies based on a combination of dynamic contrast enhanced (DCE) and dynamic susceptibility contrast (DSC) MRI or using machine‐learning algorithms on a set of different MRI modalities suggest that these techniques are promising candidates for distinguishing between vasogenic edema and tumor‐containing edema, which appear similar in conventional MRI. The method presented here reveals a new biological aspect of peritumoral alterations in glioblastomas and may thus help with this differentiation, which is important for therapy response assessment.…”
Section: Discussionmentioning
confidence: 99%
“…The finding of elevated absolute qT1‐difference values in the edema region stands in line with the results of several previous MRI and MRS studies that also show changes for different MR parameters beyond the enhancing part of glioblastomas: a stripe‐like pattern of regional CBV increase was found in a defined region adjacent to the contrast‐enhancing tumor, which then transformed into enhancing tumor tissue in the follow‐up; the VOI analysis of BOLD‐based relative oxygen extraction fraction (rOEF) maps revealed potentially hypoxic tumor regions with high rOEF in the nonenhancing infiltration zone; peritumoral fiber structures showed significant decreases of N‐acetyl‐aspartate concentrations and fiber densities when compared with the contralateral side . Further studies based on a combination of dynamic contrast enhanced (DCE) and dynamic susceptibility contrast (DSC) MRI or using machine‐learning algorithms on a set of different MRI modalities suggest that these techniques are promising candidates for distinguishing between vasogenic edema and tumor‐containing edema, which appear similar in conventional MRI. The method presented here reveals a new biological aspect of peritumoral alterations in glioblastomas and may thus help with this differentiation, which is important for therapy response assessment.…”
Section: Discussionmentioning
confidence: 99%
“…Further studies used at higher order tractography at higher 3-T scanner combined with other advanced MR sequences will improve the results. [30][31][32][33][34]…”
Section: Discussionmentioning
confidence: 99%
“…This study not only showed the differentiation between the two different brain pathologies evaluated (meningioma and GBM) but also suggests a differentiation between the edema around both intracranial tumors. Edema surrounding GBM is known to contain both vasogenic and tumor cell infiltration while edema surrounding meningioma is a vasogenic type without tumor cell infiltration [ 6 ].…”
Section: Discussionmentioning
confidence: 99%
“…GBM is the most malignant (WHO grade IV) form of intracranial tumor. Its histological characteristics are quite noticeable, with the presence of dead cells (necrotic tissue) and increased blood vessel density around the tumor [ 3 , 5 - 6 ]. Most cases of meningioma, on the other hand, involve benign tumors, many of which contain calcifications, cysts, or concentrated clusters of blood vessels.…”
Section: Introductionmentioning
confidence: 99%