Differentiation and Separation of the Tetracycline Antibiotics by Countercurrent Distribution

Minieri, P. Paul; Mistretta, A.G.

doi:10.1126/science.122.3182.1234

Cited by 3 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well-known that the recovery efficiency of cocurrent operation cannot exceed one theoretical separation stage. Countercurrent operation is a common method to increase the recovery efficiency. − Most conventional types of extraction equipment mentioned above are generally counter-current-flow operated. However, it is difficult to realize countercurrent flow in microfluidic devices because the surface wetting and viscosity effects are much larger than gravity and inertial effects .…”

Section: Introductionmentioning

confidence: 99%

Hydrodynamics and Mass Transfer in a Countercurrent Multistage Microextraction System

Lan

Jing

et al. 2016

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

In our previous study, a bionic system simulating the cardiovascular system was built to realize a countercurrent multistage microextraction. However, further study on the hydrodynamics and mass transfer performances of such a system is still needed. In this study, a theoretical model was first established to describe the relationship between the pressure drop and the flow rate. The flow resistance, including the effect of the two-phase interface, was investigated based on the theoretical model and experimental data. The mass transfer coefficient was then investigated by experiments and computational fluidic dynamics (CFD) simulation. The overall mass transfer coefficient was found positively correlated with the slug velocity. Both the aqueous phase mass transfer coefficient and the organic phase mass transfer coefficient were obtained by CFD simulation. A correlation equation was established to calculate the Sherwood number, and it is proved to be applicable in both the aqueous and the organic phases.

show abstract

Section: Introductionmentioning

confidence: 99%

Hydrodynamics and Mass Transfer in a Countercurrent Multistage Microextraction System

Lan

Jing

et al. 2016

Ind. Eng. Chem. Res.

View full text Add to dashboard Cite

show abstract

“…Though the mass transfer speed is much faster than that of the conventional extractors, the recovery efficiency of the cocurrent microextraction can reach no higher than that of a conventional device with a single theoretical separation stage. To increase recovery efficiency, countercurrent flow of two immiscible liquids to achieve multi-stage extraction is often used, [19][20][21][22] but it is difficult to realize countercurrent flow at the micro-scale because viscosity and surface wetting dominate over gravity and inertial effects. 23 Difficulty in achieving countercurrent two-phase flow has been a barrier to the application of microextraction in chemical processes.…”

mentioning

confidence: 99%