Differentiating toxic and nontoxic congeneric harmful algae using the non-polar metabolome

Brown, Emily R.; Moore, Samuel G; Gaul, David A.; Kubanek, Julia

doi:10.1016/j.hal.2021.102129

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Our review is the first to discuss Alexandrium potential also for marine bioprospecting. Considering the harmfulness of many Alexandrium species, several studies have focused on the identification of toxins, enzymatic pathways responsible of their synthesis [26], transcriptomics [26][27][28], metabolomics [29], as well as various detection methods, ranging from microscopic examinations to real-time PCR-based assays [30,31]. However, species which do not produce toxins have been shown to exert bioactivities [32].…”

Section: Introductionmentioning

confidence: 99%

Alexandrium spp.: From Toxicity to Potential Biotechnological Benefits

Montuori,

De Luca,

Penna

et al. 2023

Marine Drugs

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Many dinoflagellates of the genus Alexandrium are well known for being responsible for harmful algal blooms (HABs), producing potent toxins that cause damages to other marine organisms, aquaculture, fishery, tourism, as well as induce human intoxications and even death after consumption of contaminated shellfish or fish. In this review, we summarize potential bioprospecting associated to the genus Alexandrium, including which Alexandrium spp. produce metabolites with anticancer, antimicrobial, antiviral, as well as anti-Alzheimer applications. When available, we report their mechanisms of action and targets. We also discuss recent progress on the identification of secondary metabolites with biological properties favorable to human health and aquaculture. Altogether, this information highlights the importance of studying which culturing conditions induce the activation of enzymatic pathways responsible for the synthesis of bioactive metabolites. It also suggests considering and comparing clones collected in different locations for toxin monitoring and marine bioprospecting. This review can be of interest not only for the scientific community, but also for the entire population and industries.

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