Differentiating patterns of oligoclonal banding in the cerebrospinal fluid improves diagnostic utility for multiple sclerosis

Lin, Ming‐Wei; Suan, Dan; Lenton, Kerry; Henniker, Tony; Burke, Therese; Vucic, Steve; Fulcher, David A.

doi:10.1097/pat.0b013e3283511a87

Cited by 8 publications

(4 citation statements)

References 10 publications

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“…For o-IgG, such findings have been found to be unreliable 27 and mostly unrelated to the diagnosis of MS (ref. 28 ). On the other hand, a few patients with such a finding, or even a single CSF-restricted band 29,30 , may have MS (ref.…”

Section: Discussionmentioning

confidence: 99%

Oligoclonal free light chains in cerebrospinal fluid as markers of intrathecal inflammation. Comparison with oligoclonal IgG

Zeman¹,

Hradílek²,

Kušnierová³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Aims.To compare the sensitivity and specificity of CSF-restricted oligoclonal IgG and free light chains as markers of multiple sclerosis and other inflammatory neurological diseases. Methods. 196 paired CSF and serum samples were examined for oligoclonal IgG and oligoclonal free light chains. The sensitivity and specificity of the tests were calculated and optimal cut-offs for the number of CSF-restricted oligoclonal bands were then determined by analysis of receiver operating characteristic curves. Results. Optimal cut-off values were ≥5 IgG bands for multiple sclerosis, ≥4 IgG bands for inflammatory neurological disease, ≥6 free κ, and ≥2 free λ bands for both purposes. Using these cut-off values, sensitivities and specificities for multiple sclerosis were 83.8% and 91.3% for IgG, 83.8% and 81.0% for free κ , and 67.6% and 75.4% for free λ. For inflammatory neurological disease, sensitivities and specificities were 60.8% and 95.7% for IgG, 69.6% and 92.6% for free κ, and 64.8% and 86.2% for free λ. Conclusions. Although exact cut-off values may vary according to method, reporting borderline results as positive, may compromise the specificity of the test and should be avoided.. The detection of intrathecal free light chain synthesis may be of value especially when the oligoclonal IgG test is negative or borderline, even though its specificity is slightly lower.

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Section: Discussionmentioning

confidence: 99%

Oligoclonal free light chains in cerebrospinal fluid as markers of intrathecal inflammation. Comparison with oligoclonal IgG

Zeman¹,

Hradílek²,

Kušnierová³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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“…These data show that the eastern and far-eastern populations had a higher OCB (-) MS ratio or the findings may be the result of the method used and the subjective interpretation of the result. 15 Andlovic et al 16 showed that the novel alkaline phosphatase assay is more sensitive than the standard peroxidase method for detection of OCBs. They compared the two methods and concluded that in patients with clinically isolated syndrome and MS OCB were more often present when analysis was performed by using the novel assay.…”

Section: Discussionmentioning

confidence: 99%

Comparison of neurophysiological and mri findings of patients with multiple sclerosis using oligoclonal band technique

Elli̇dağ¹,

Eren

Erdoğan

et al. 2013

ANS

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BackgroundThe correlation of oligoclonal bands (OCBs) and intrathecal IgG synthesis are not yet clear in multiple sclerosis (MS).PurposeIn this study, we investigated the OCB situation and IgG index, cranial and cervical magnetic resonance imaging (MRI) findings and also compared visual evoked potentials (VEP) and somatosensorial evoked potentials (SEP) in order to better understand the OCB pattern and pathogenesis.MethodsRetrospective study included 40 patients (19 male, 21 female, mean age 29 ± 4,24) with precise MS diagnosis according to McDonald criteria.ResultSixteen of the patients were OCB negative, and 24 patients were positive. The different between the OCB situation and number of plaques in cranial and cervical MRI, atrophy, oedema and contrast material retention were insignificant. The different between the OCB situation and VEP and SEP were insignificant.ConclusionThese laboratory findings are all specific, all developing via independent mechanisms and are not related to each other during the silence periods of patients.

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“…Concerning the role and significance of antibodies in MS patients, the presence of CSF oligoclonal bands and increased immunoglobulin IgG synthesis is a frequent feature of MS [87] as well as other localized autoimmune diseases of the CNS [88]. These pathogenic autoantibodies (autoAbs) can induce tissue damage and thus be involved in plaque initiation and demyelination by recruiting macrophages and by complement deposition in white matter lesion of MS patients [89].…”

Section: Humoral Immunity Proteasomes and Msmentioning

confidence: 99%

Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

Bellavista

Santoro

Galimberti

et al. 2014

Autoimmune Diseases

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The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS). Both ex vivo analyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS. Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+ and CD4+ T cells and B cells as well as neurons during MS development. Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS. Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS. In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss the pro et contra of possible therapies for MS targeting proteasome isoforms.

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Differentiating patterns of oligoclonal banding in the cerebrospinal fluid improves diagnostic utility for multiple sclerosis

Cited by 8 publications

References 10 publications

Oligoclonal free light chains in cerebrospinal fluid as markers of intrathecal inflammation. Comparison with oligoclonal IgG

Oligoclonal free light chains in cerebrospinal fluid as markers of intrathecal inflammation. Comparison with oligoclonal IgG

Comparison of neurophysiological and mri findings of patients with multiple sclerosis using oligoclonal band technique

Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

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