Differentiating Melancholic and Non-melancholic Major Depressive Disorder Using Fractional Amplitude of Low-Frequency Fluctuations

Zhang, Yingying; Cui, Xilong; Ou, Yangpan; Liu, Feng; Li, Huabing; Chen, Jindong; Zhao, Jingping; Xie, Gary; Guo, Wenbin

doi:10.3389/fpsyt.2021.763770

Cited by 4 publications

(2 citation statements)

References 119 publications

(194 reference statements)

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“…Brain network analysis has also demonstrated that MD patients exhibit distinctive changes in DMN homogeneity [16]. In addition, recent studies have shown that patients with MD and NMD differ in terms of the amplitude of low-frequency fluctuation, regional homogeneity, and voxel-mirrored homotopic connectivity [17–19]. These differences may be used to distinguish between the two subtypes of MDD.…”

Section: Introductionmentioning

confidence: 99%

Atrophy of bilateral nucleus accumbens in melancholic depression

Chu

Yuan

et al. 2023

NeuroReport

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Evidence from previous literature suggests that the nucleus accumbens (NAc), hippocampus, and amygdala play critical roles in the reward circuit. Meanwhile, it was also suggested that abnormalities in the reward circuit might be closely associated with the symptom of anhedonia of depression. However, few studies have investigated the structural alterations of the NAc, hippocampus, and amygdala in depression with anhedonia as the main clinical manifestation. Thus, the current study aimed to explore the structural changes of the subcortical regions among melancholic depression (MD) patients, especially in the NAc, hippocampus, and amygdala, to provide a theoretical basis for understanding the pathological mechanisms of MD. Seventy-two MD patients, 74 nonmelancholic depression (NMD) patients, and 81 healthy controls (HCs) matched for sex, age, and years of education were included in the study. All participants underwent T1-weighted MRI scans. Subcortical structure segmentation was performed using the FreeSurfer software. MD and NMD patients had reduced left hippocampal volume compared with HCs. Meanwhile, only MD patients had reduced bilateral NAc volumes. Moreover, correlation analyses showed correlations between left NAc volume and late insomnia and lassitude in MD patients. The reduced hippocampal volume may be related to the pathogenesis of major depressive disorder (MDD), and the reduced volume of the NAc may be the unique neural mechanism of MD. The findings of the current study suggest that future studies should investigate the different pathogenic mechanisms of different subtypes of MDD further to contribute to the development of individualized diagnostic and treatment protocols.

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Section: Introductionmentioning

confidence: 99%

Atrophy of bilateral nucleus accumbens in melancholic depression

Chu

Yuan

et al. 2023

NeuroReport

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“…There are also several studies about melancholic MDD. These studies found that the melancholic MDD had distinct fractional ALFF values in the right middle temporal gyrus (MTG)/and bilateral superior occipital gyrus (SOG) ( 43 ), lower ReHo values in the right SOG/middle occipital gyrus (MOG) ( 44 ), different network homogeneity values in the right posterior cingulate cortex (PCC)/precuneus, right angular gyrus, and the right MTG ( 45 ), decreased voxel-mirrored homotopic connectivity values in the fusiform gyrus, PCC, and SOG ( 46 ). As a promising approach to rs-fMRI, ALFF has been adopted widely because it can reflect the spontaneous neuronal activity of specific regions ( 47 ).…”

Section: Introductionmentioning

confidence: 99%

The aberrant dynamic amplitude of low-frequency fluctuations in melancholic major depressive disorder with insomnia

Deng

Jiang

et al. 2022

Front. Psychiatry

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BackgroundInsomnia is considered one of the manifestations of sleep disorders, and its intensity is linked to the treatment effect or suicidal thoughts. Major depressive disorder (MDD) is classified into various subtypes due to heterogeneous symptoms. Melancholic MDD has been considered one of the most common subtypes with special sleep features. However, the brain functional mechanisms in melancholic MDD with insomnia remain unclear.Materials and methodsMelancholic MDD and healthy controls (HCs, n = 46) were recruited for the study. Patients were divided into patients with melancholic MDD with low insomnia (mMDD-LI, n = 23) and patients with melancholic MDD with high insomnia (mMDD-HI, n = 30), according to the sleep disturbance subscale of the 17-item Hamilton Depression Rating Scale. The dynamic amplitude of low-frequency fluctuation was employed to investigate the alterations of brain activity among the three groups. Then, the correlations between abnormal dALFF values of brain regions and the severity of symptoms were investigated.ResultsLower dALFF values were found in the mMDD-HI group in the right middle temporal gyrus (MTG)/superior temporal gyrus (STG) than in the mMDD-LI (p = 0.014) and HC groups (p < 0.001). Melancholic MDD groups showed decreased dALFF values than HC in the right middle occipital gyri (MOG)/superior occipital gyri (SOG), the right cuneus, the bilateral lingual gyrus, and the bilateral calcarine (p < 0.05). Lower dALFF values than HC in the left MOG/SOG and the left cuneus in melancholic MDD groups were found, but no significant difference was found between the mMDD-LI group and HC group (p = 0.079). Positive correlations between the dALFF values in the right MTG/STG and HAMD-SD scores (the sleep disturbance subscale of the HAMD-17) in the mMDD-HI group (r = 0.41, p = 0.042) were found. In the pooled melancholic MDD, the dALFF values in the right MOG/SOG and the right cuneus (r = 0.338, p = 0.019), the left MOG/SOG and the left cuneus (r = 0.299, p = 0.039), and the bilateral lingual gyrus and the bilateral calcarine (r = 0.288, p = 0.047) were positively correlated with adjusted HAMD scores.ConclusionThe occipital cortex may be related to depressive symptoms in melancholic MDD. Importantly, the right MTG/STG may play a critical role in patients with melancholic MDD with more severe insomnia.

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