Differentiating Glioblastoma from Primary Central Nervous System Lymphoma: The Value of Shaping and Nonenhancing Peritumoral Hyperintense Gyral Lesion on FLAIR Imaging

Wang, Ping; Shi, Ying‐Hong; Jian-ye, LI; Zhang, Cheng-Zhou

doi:10.1016/j.wneu.2021.01.114

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…[ 20 ] The general characteristics that high-grade glioma shares with PCNSL are the presence of thick enhancement, periventricular locations, and vasogenic edema; however, most are heterogeneous, with irregular borders, and have a necrotic center and a hemorrhagic component. [ 1 , 13 , 30 , 32 ]…”

Section: Discussionmentioning

confidence: 99%

Primary central nervous system lymphoma: A mirror type presentation in an immunocompetent patient

Chávez,

Arce,

Perea

et al. 2024

Surgical Neurology International

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Background: Primary central nervous system (CNS) lymphoma is a very rare extranodal non-Hodgkin lymphoma. The bilateral pattern, as we call it “mirror type”, has been identified in other CNS lesions such as gliomas, metastases, and demyelinating lesions, so the differential diagnosis includes imaging studies such as magnetic resonance imaging contrasted with spectroscopy, ruling out immunodeficiency or metastatic disease. Case Description: A 65-year-old female presented progressing headache, loss of memory and language alterations, as well as sensory alterations. Neuroimaging showed the presence of two equidistant periventricular lesions at the level of both ventricular atria, a spectroscopy study suggestive of malignancy. Serological studies showed no evidence of immunodeficiency or the presence of positive tumor markers; however, a biopsy was performed, which revealed a histopathological result of primary lymphoma of the CNS. Conclusion: In neuro-oncology, primary CNS tumors with multiple lesions are rare, even more, the “mirror type” lesions. Lymphomas are lesions that can present in different ways on imaging and clinical presentation. These tumors that present a vector effect due to their size, perilesional edema, or that lead to loss of neurological function are highly discussed in diagnostic and surgical treatment. Due to their prognosis, action on diagnosis and treatment must be taken as quickly as hospital resources allow.

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Section: Discussionmentioning

confidence: 99%

Primary central nervous system lymphoma: A mirror type presentation in an immunocompetent patient

Chávez,

Arce,

Perea

et al. 2024

Surgical Neurology International

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show abstract

“…On MRI perfusion imaging, PCNSL is always lower than other intracranial tumors, such as meningiomas, metastases and high grade gliomas. It is due to the low induction of tumor neovascularization and increases in vascular permeability after the destruction of the blood–brain barrier [ 12 , 13 , 14 ]. Therefore, the edge of the enhancement in the tumor is often relatively blurred and the surrounding edema is obvious.…”

Section: Discussionmentioning

confidence: 99%

Preliminary clinical application of multimodal imaging combined with frameless robotic stereotactic biopsy in the diagnosis of primary central nervous system lymphoma

Tang

Shi²,

Qian³

et al. 2022

Heliyon

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Brain tumor segmentation with missing MRI modalities using edge aware discriminative feature fusion based transformer U-net

Jagadeesh,

Anand Kumar

2024

Applied Soft Computing

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Differentiating Glioblastoma from Primary Central Nervous System Lymphoma: The Value of Shaping and Nonenhancing Peritumoral Hyperintense Gyral Lesion on FLAIR Imaging

Cited by 5 publications

References 19 publications

Primary central nervous system lymphoma: A mirror type presentation in an immunocompetent patient

Primary central nervous system lymphoma: A mirror type presentation in an immunocompetent patient

Preliminary clinical application of multimodal imaging combined with frameless robotic stereotactic biopsy in the diagnosis of primary central nervous system lymphoma

Brain tumor segmentation with missing MRI modalities using edge aware discriminative feature fusion based transformer U-net

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