Differentiating fasciculations from myoclonus in motor neuron disease

Walker, Susan L.; Simon, Neil

doi:10.1016/j.cnp.2017.12.001

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Peripheral and Central Variants1

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“…Grippe et al [ 36 ] have described minipolymyoclonus as “an irregular 1–20 Hz activity with muscle synchronous bursts of 25–50 ms in duration” that can arise from a peripheral or central generator. However, peripherally originating minipolymyoclonus from degenerating motor neurons generally has an EMG burst duration of < 20 ms, similar to a typical motor unit potential [ 8 , 37 ]. In contrast, centrally originating minipolymyoclonus typically has a burst duration of < 100 ms (typically 20–50 ms) [ 30 ].…”

Section: Peripheral and Central Variantsmentioning

confidence: 99%