Differentiating Between Benign and Malignant Pleural Effusions

Payne, D. Keith; Owens, Michael W.

doi:10.1201/b14205-20

Cited by 3 publications

(3 citation statements)

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“…Small pleural effusions can be present on imaging in patients with methotrexate-, procarbazine-, or ATRA-induced pneumonitis, especially if the reaction is severe. 9,111 Bleomycin, cyclophosphamide, IL-2, immunoglobulins, methotrexate, radiation therapy, and ATRA can produce lone exudative pleural effusions. 9,111 Bilateral pleural thickening is a distinctive form of late cyclophosphamide toxicity.…”

Section: Pleural Involvementmentioning

confidence: 99%

“…9,111 Bleomycin, cyclophosphamide, IL-2, immunoglobulins, methotrexate, radiation therapy, and ATRA can produce lone exudative pleural effusions. 9,111 Bilateral pleural thickening is a distinctive form of late cyclophosphamide toxicity. 73,112 Pneumothorax can complicate late drug-induced pulmonary changes, requiring specific management.…”

Section: Pleural Involvementmentioning

confidence: 99%

“…Pleural thickening or an effusion is distinctly unusual. 111 Pulmonary function tests (PFTs) reveal a restrictive lung function defect with hypoxemia and reduced DLCO that predates the onset of overt toxicity by weeks. The BAL pattern is neutrophilic.…”

Section: Drugs That Produce Toxicity In Patients With Hematological Dmentioning

confidence: 99%

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Drug-Induced Respiratory Disease in Patients with Hematological Diseases

Camus¹,

Costabel²

2005

Seminars in Respiratory and Critical Care Medicine

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Patients with hematological malignancies or recipients of hematopoietic stem cell transplants may develop myriad pulmonary manifestations, as a complication of either the disease or the diverse agents used to treat the disease. Clinical, radiographic, and physiological features of drug-induced and radiation-induced pulmonary injury are often difficult to distinguish from other causes of pulmonary infiltrates (e.g., infections, pulmonary edema, alveolar hemorrhage, etc.). Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is essential to exclude infectious etiologies. In some cases, surgical lung biopsies are required to establish a specific etiological diagnosis. This review discusses the myriad causes of lung injury/toxicity that may afflict patients with hematological malignancies or transplant recipients, and presents diagnostic and therapeutic approaches.

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Section: Pleural Involvementmentioning

confidence: 99%