Differentiating Between Apathy and Depression in Patients With Parkinson Disease Dementia

Camargo, Carlos Henrique Ferreira; Serpa, Rafael Arthur; Jobbins, V.; Berbetz, F.; Sabatini, Jivago Szpoganicz

doi:10.1177/1533317517728333

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…On the other hand, we found that depression correlated with apathy. Depression and apathy are the most frequent neuropsychiatric disorders in neurodegenerative diseases and their co‐occurrence is expected in many parkinsonian syndromes (Camargo et al., 2018 ; Santangelo et al., 2018 ) and dementias (Collins et al., 2020 ). Distinguishing apathy from depression can be a major challenge due to an overlap in symptom, despite many studies suggested that they are separate entities underlined by different neural networks (Isella et al., 2002 ; Kirsch‐Darrow et al., 2006 ; Mayberg, 1994 ; Pluck & Brown, 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Psychometric properties of the Beck Depression Inventory‐II in progressive supranuclear palsy

et al. 2021

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Objectives: Depression is one of the most common neuropsychiatric symptoms in progressive supranuclear palsy (PSP). Yet, few studies have examined the ability of available instruments to detect depressive symptoms in PSP. Aims of the present study were to (I) report psychometric properties of the Beck Depression Inventory Second Edition (BDI-II) in PSP, (II) establish the BDI-II cut-off indicating the presence of depression in PSP and (III) describe clinical correlates as well as correlation with quality of life of depressive symptoms in PSP. Design, setting and participants: : At the Center for Neurodegenerative Diseases of the University of Salerno, Italy, the BDI-II was validated in 62 PSP patients diagnosed according to the Movement Disorder Society criteria. Patients underwent a clinical interview, a motor evaluation, extensive cognitive and behavioral testing. Results:The mean BDI-II total score was 15.92 ± 10.31. The internal consistency was high (Cronbach's alpha = 0.868); corrected item-total correlation was >0.40 for the majority of items. The significant and moderate correlation of the BDI-II with other tools evaluating depressive symptoms indicated adequate convergent validity of the scale. The satisfactory cut-off to identify patients with clinically significant depression was >14.5. We also showed a correlation between higher scores on BDI-II and lower quality of life, irrespective of motor and cognitive burden. Conclusion:In conclusion, the BDI-II is a reliable and valid tool for the assessment of depression symptoms in PSP. Such data are useful to standardize studies of depression in PSP and to quantify the effectiveness of any interventions on this disabling symptom.

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Section: Discussionmentioning

confidence: 99%

Psychometric properties of the Beck Depression Inventory‐II in progressive supranuclear palsy

et al. 2021

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“…For numerous somatic diseases, an association with depression is well-established. For example, patients with multiple sclerosis (8), stroke (9), parkinson's disease (10), diabetes mellitus (11), breast cancer (12) or heart failure (13) have an elevated risk for developing a major depressive disorder (MDD). From a psychiatric perspective, it is important to note that a recently published study with 1,237,194 participants showed that individuals who exercised (various types of disciplines) had 1.49 (43.2%) fewer days of poor mental health in the past month than non-exercising individuals (14).…”

Section: Introductionmentioning

confidence: 99%

Depression in Somatic Disorders: Is There a Beneficial Effect of Exercise?

et al. 2019

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Background: The beneficial effects of exercise training on depressive symptoms are well-established. In the past years, more research attention has been drawn to the specific effects of exercise training on depressive symptoms in somatically ill patients. This reviews aims at providing a comprehensive overview of the current findings and evidence of exercise interventions in somatic disorders to improve depressive symptoms.Methods: We systematically searched PubMed and Cochrane databases and extracted meta-analyses from somatically ill patients that underwent exercise interventions and provided information about the outcome of depressive symptoms.Results: Of the 4123 detected publications, 39 were selected for final analysis. Various diseases were included (breast-cancer, prostate cancer, mixed-cancer, cardiovascular disease, coronary heart disease, hemodialysis, fibromyalgia syndrome, acute leukemia, other hematological malignancies, heart failure, HIV, multiple sclerosis, mixed neurological disorders, Parkinson's disease, stroke, ankylosing spondylitis, traumatic brain injury, lupus erythematodes). Most meta-analyses (33/39) found beneficial effects on depressive symptoms, but quality of the included studies as well as duration, intensity, frequency, and type of exercise varied widely.Conclusion: Exercise training has the potential to improve depressive symptoms in patients with somatic disorders. For specific training recommendations, more high quality studies with structured exercise programs and better comparability are needed.

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“…Emerging literature has shown a relationship between psychological symptoms like depression and risk of neurodegenerative disorders including dementia ( Bennett & Thomas, 2014 ; Landes, Sperry, Strauss, & Geldmacher, 2001 ; Nagayama et al, 2016 ; Oguru, Tachibana, Toda, Okuda, & Oka, 2010 ). Recent investigations highlight apathy as a separate entity from depression ( Marin, Fogel, Hawkins, Duffy, & Krupp, 1995 ; Starkstein, Petracca, Chemerinski, & Kremer, 2001 ), which has been uniquely associated with cognitive and functional decline in neurologic diseases ( Camargo, Serpa, Jobbins, Berbetz, & Sabatini, 2018 ; Palmer et al, 2010 ; Vicini Chilovi et al, 2009 ). Apathy predicts worse functional and cognitive outcomes after a stroke and in Parkinson’s disease (PD) ( Caeiro, Ferro, & Costa, 2013 ; Cohen, Aita, Mari, & Brandt, 2015 ; Hama et al, 2007 ).…”

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confidence: 99%

Apathy and the Risk of Predementia Syndromes in Community-Dwelling Older Adults

Ceïde

Warhit

Ayers

et al. 2020

The Journals of Gerontology: Series B

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Objectives Apathy is a potential predictor of dementia in older adults, but this investigation has been limited to older adults with a preexisting neurological illness like mild cognitive impairment (MCI), stroke or Parkinson’s disease. The objective of this study was to investigate the association between apathy at baseline and incident predementia syndromes, including MCI and motoric cognitive risk syndrome (MCR), subjective cognitive complaints and slow gait, in community-dwelling older adults. Method We prospectively studied the association between apathy (using the 3-item subscale of the Geriatric Depression Scale [GDS3A]) and incident cognitive disorders in 542 community-dwelling older adults enrolled in the Central Control of Mobility in Aging study using Cox proportional hazard models. Associations were reported as hazard ratio (HR) with 95% confidence intervals (CIs), adjusting for age, education, baseline cognitive performance, and depressive symptoms. Results Apathy was associated with incident MCR (HR 2.39, 95% CI: 1.10–5.20), but not predementia syndromes overall nor MCI. In sensitivity analyses of MCI subtypes, apathy was associated with nonamnestic MCI (HR 2.44, 95% CI: 1.14–5.22), but not amnestic MCI. Our study was limited by a short follow-up time (median 13.6 months; interquartile range 29.8) and a brief subscale measurement of apathy, GDS3A. Discussion In our study, apathy predicted MCR but not MCI in community-dwelling older adults. These results and the current literature suggest that apathy is an early risk factor for dementia. Additionally, apathy may be a novel treatment target that could forestall the disability of dementia.

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Differentiating Between Apathy and Depression in Patients With Parkinson Disease Dementia

Cited by 16 publications

References 31 publications

Psychometric properties of the Beck Depression Inventory‐II in progressive supranuclear palsy

Psychometric properties of the Beck Depression Inventory‐II in progressive supranuclear palsy

Depression in Somatic Disorders: Is There a Beneficial Effect of Exercise?

Apathy and the Risk of Predementia Syndromes in Community-Dwelling Older Adults

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