Differentiating Benign from Malignant Solid Breast Masses with US Strain Imaging

Burnside, Elizabeth S.; Hall, Timothy J.; Sommer, Amy M.; Hesley, Gina K.; Sisney, Gale A.; Svensson, W. E.; Fine, Jason P.; Jiang, Jinfeng; Hangiandreou, Nicholas J.

doi:10.1148/radiol.2452061805

Cited by 280 publications

(214 citation statements)

References 29 publications

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“…8 Malignant tumors have reduced elasticity and also display larger dimensions on elastography due to accompanying desmoplastic reaction. 9 The purpose of this study was to evaluate the diagnostic utility of SE in differentiating benign from malignant breast lesions in peripheral part of West Bengal.…”

Section: Introductionmentioning

confidence: 99%

Application of Sonoelastography in Reducing the Invasive Investigations to Diagnose Breast Malignancy

Chakrabarti¹,

Rahaman²,

Basu³

2016

jemds

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Section: Introductionmentioning

confidence: 99%

Application of Sonoelastography in Reducing the Invasive Investigations to Diagnose Breast Malignancy

Chakrabarti¹,

Rahaman²,

Basu³

2016

jemds

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“…The clinical potential of elasticity imaging has been demonstrated in imaging breast (Regner et al 2006;Burnside et al 2007), cardiovascular disease (Pislaru et al 2004;Trahey et al 2004), and fibrosis (Sandrin et al 2003), amongst others.…”

Section: Introductionmentioning

confidence: 99%

Shear Wave Elasticity Imaging Based on Acoustic Radiation Force and Optical Detection

et al. 2012

Ultrasound in Medicine & Biology

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Abstract:Tissue elasticity is closely related to the velocity of shear waves within biological tissue.Shear waves can be generated by an acoustic radiation force and tracked by, e.g., ultrasound or MRI measurements. This has been shown to be able to non-invasively map tissue elasticity in depth and has great potential in a wide range of clinical applications including cancer and cardiovascular diseases. In this study a highly sensitive optical measurement technique is proposed as an alternative way to track shear waves generated by the acoustic radiation force.A CCD camera was used to capture diffuse photons from tissue mimicking phantoms illuminated by a laser source at 532nm. CCD images were recorded at different delays after the transmission of an ultrasound burst, and were processed to obtain the time of flight for the shear wave. A differential measurement scheme involving generation of shear waves at two different positions was used to improve the accuracy and spatial resolution of the system. The results from measurements on both homogeneous and heterogeneous phantoms were compared to measurements from other instruments, and demonstrate the feasibility and accuracy of the technique for imaging and quantifying elasticity. The relative error in estimation of shear wave velocity can be as low as 5.5% with a spatial resolution of 2 mm.The system is shown to be highly sensitive and is able to track shear waves propagating over several centimetres given the ultrasound excitation amplitude and the phantom material used in this study. It was also found that the reflection of shear waves from boundaries between regions with different elastic properties can cause significant bias in the estimation of elasticity, which also applies to other shear wave tracking techniques. This bias can be reduced at the expense of reduced spatial resolution.

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“…For this evaluation, a software is used in which soft lesions seem to be bright, hard lesions seem to be dark and malignant lesions are more specific than benign lesions. On the other hand tissues seem to be in different color spectrum according to their hardness [6][7][8][9][10][11]. Yet, there is no agreement on the method or classification which has the most clinical applicability.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Tumoral Prognostic Factors by Sonoelastography Score in Patients to be Operated Due to Breast Cancer

et al. 2012

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Predictability of pre-op prognosis on patient with a diagnosis of breast cancer is quite valuable for the choice of both surgical technique and adjuvant therapy. With the aim of evaluation of sonoelastography score utility in this respect, correlation of tumoral prognostic factors by sonoelastography score in patients be operated due to breast cancer was analyzed on our study. Pre-op sonoelastography results and tumoral hystopathological properties of 60 patients operated with a diagnosis of breast cancer in 2011 at Adnan Menderes University Faculty of Medicine General Surgery Department were analyzed retrospectively. As an elastography scoring method, "Tsukuba scoring system" was used. Statistically significant differences(p<0,05) were determined between tumor grade and Ki-67 analyzed as prognostic factor with tumors reported as sonoelastography score 4 and score 5, on the other hand there were no statistically significant differences between tumor size, positivity of axillary lymph nodes, significance of lymphovascular invasion, p-53 positivity, CerbB-2 positivity, hormone receptor positivity, tumor hysthologic type and applied surgical technique between tumors reported as elastography score 4 and score 5. (p>0.005). Foresee ability of prognostic factors correlation by sonoelastography score will be guide way for the choice of surgery technique, determination of adjuvant therapy and patient follow-up.

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Differentiating Benign from Malignant Solid Breast Masses with US Strain Imaging

Abstract: US strain imaging can facilitate improved classification of benign and malignant breast masses. However, interobserver variability and image quality influence observer performance.

Cited by 280 publications

References 29 publications

Application of Sonoelastography in Reducing the Invasive Investigations to Diagnose Breast Malignancy

Application of Sonoelastography in Reducing the Invasive Investigations to Diagnose Breast Malignancy

Shear Wave Elasticity Imaging Based on Acoustic Radiation Force and Optical Detection

Correlation of Tumoral Prognostic Factors by Sonoelastography Score in Patients to be Operated Due to Breast Cancer

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