Differentiated thyroid cancer in patients with prolactinoma

Tam, Abbas Ali; Kaya, Cafer; Aydın, Cevdet; Ersoy, Reyhan; Çakır, Bekir

doi:10.1530/endoabs.37.ep740

Cited by 2 publications

(5 citation statements)

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“…One reason for this could be that routine thyroid USG was not performed in these patients, and every patient with a neck USG due to any other reason, including suspicious findings during thyroid palpation, was included in this study. However, in two recent studies, an increased frequency of NTD was reported in prolactinoma patients (11,12), and two other studies demonstrated increased NTD frequency in patients with CD compared to the general population (14,15). Although NTD was more common in patients with acromegaly, dominant nodule size and distribution of single or multiple nodules were similar in all three groups.…”

Section: Discussionmentioning

confidence: 81%

“…Screening for papillary thyroid carcinoma (PTC) is recommended in patients with acromegaly due to their higher risk of developing tumors, but not for prolactinoma and CD patients (2)(3)(4)(5)(6)(7)(8)(9)(17)(18)(19)(20)(21). We found only one study that evaluated the prevalence of PTC in prolactinomas (12) and one case report on the co-existence of CD and PTC (22). We detected a higher frequency of NTD in CD and prolactinoma patients in our clinical practice, along with a concurrent increase in PTC diagnosis.…”

Section: Introductionmentioning

confidence: 68%

“…In our study also, PTC frequencies were 10.8%, 3.4% and 11.4% in the acromegalic, prolactinoma and CD patients, respectively. One study reported the PTC rate in prolactinomas as 5% (12), while only one case report so far has incidentally detected PTC in CD patients (22). In contrast, PTC is fairly common in patients with acromegaly (2-9, 17-21).…”

Section: Discussionmentioning

confidence: 99%

“…An increased frequency of NTD has also been reported in individuals with functional pituitary adenoma (FPA); acromegaly is more frequently associated with NTD compared to Cushing's disease (CD) or prolactinoma (2)(3)(4)(5)(6)(7)(8)(9)(10). However, an increased risk of NTD in patients with CD and prolactinoma has been reported in recent studies (11)(12)(13)(14)(15). Although thyroid nodules are common, only 8-16% of them are malignant (16).…”

Section: Introductionmentioning

confidence: 99%

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Nodular Thyroid Disease and Papillary Thyroid Carcinoma in Functional Pituitary Adenomas

Dogansen¹,

Yalin²,

Tanrikulu³

et al. 2018

Turk J Endocrinol Metab

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Objective: Increased frequency of nodular thyroid disease has been reported in acromegalic patients. Recent studies have also demonstrated an increased coexistence of nodular thyroid disease with Cushing's disease and prolactinoma. In this study, we evaluated the frequency and outcomes of nodular thyroid disease in each type of functional pituitary adenoma. Material and Methods: A total of 232 patients diagnosed with acromegaly (n=138), prolactinoma (n=59) or Cushing's disease (n=35) were included in this retrospective observational study. The frequency of nodular thyroid disease, fine-needle aspiration results, and the frequency of papillary thyroid carcinoma were compared in each group. Factors related to nodule development were evaluated in functional pituitary adenoma patients with or without nodules. Results: Nodular thyroid disease frequency was higher in patients with acromegaly (69%) compared to those with prolactinoma (36%) or Cushing's disease (34%) (p<0.001). Fine-needle aspiration results and PTC frequencies were similar between the groups. In comparison to patients without nodules (n=104), those with nodules (n=128) were older (p=0.01) and had a higher incidence of glucose metabolism disorders (p=0.006). Insulin-like growth factor-1 levels were higher in acromegalic patients with nodular thyroid disease (p=0.01). There was no relationship between nodule formation and baseline prolactin or cortisol/adrenocorticotropic hormone levels in the patients with prolactinomas and Cushing's disease, respectively. Conclusion: Although nodular thyroid disease was more common in acromegalic patients, its incidence in patients with prolactinoma and Cushing's disease were higher than previously reported in our country (23.5%). The most important factors affecting nodule formation in functional pituitary adenoma patients were glucose metabolism disorders and age. Although a higher frequency of PTC has been reported in acromegalic patients, it was similar for all functional pituitary adenoma patients in our study.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nodular Thyroid Disease and Papillary Thyroid Carcinoma in Functional Pituitary Adenomas

Dogansen¹,

Yalin²,

Tanrikulu³

et al. 2018

Turk J Endocrinol Metab

View full text Add to dashboard Cite

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“…4 had a mild increase of prolactin, which is not typically related to thyroid nodules [9][10][11] . Recent studies showed an increased risk of thyroid enlargement and nodularity in patients with prolactinoma or other neuroendocrine tumours, but not of thyroid cancer [9][10][11] . High prolactin values may be related to mammary cysts of different dimensions, but not to similar lesions of the thyroid 9-11 .…”

Section: Discussionmentioning

confidence: 99%

Thyroid nodules: a puzzle in gynaecological endocrinology

Vasiliu¹,

Albu²,

Cârșote³

et al. 2019

Arch Balk Med Union

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Nodules thyroïdiens: un casse-tête dans l'endocrinologie gynécologiqueIntroduction. Nous présentons différents aspects de l'échographie thyroïdienne qui ont été référés à un endocrinologue après un examen gynécologique. Série de cas. Une femme de 73 ans a été admise pour un examen gynécologique de routine et un examen général a accidentellement détecté un nodule thyroïdien. L'échographie a montré un macronodule de 3,1 cm avec une approche chirurgicale. Une femme de 53 ans a accusé des bouffées de chaleur, associées à des épisodes d'hypertension. L'hyperthyroïdie n'est pas confirmée mais un conglomérat de nodules de 2,2 cm a été trouvé. La ponction à l'aiguille fine exclut une tumeur maligne. Une femme de 66 ans se présentant pour une évaluation osseuse est détectée accidentellement avec un goitre multinodulaire de grande ABSTRACT Introduction. We present different particular aspects of the thyroid ultrasound in patients who were first referred to an endocrinologist after a gynaecological check-up. Case series presentation. A 73-year-old woman was admitted for a routine gynaecological and general examination, after a thyroid nodule was incidentally detected. Ultrasonography showed a macronodule of 3.1 cm, that was treated by surgery. A 53-year-old woman presented for hot flashes in association with high blood pressure episodes. Hyperthyroidism was not confirmed, but a conglomerate of thyroid nodules of 2.2 cm was detected. The fine needle aspiration excluded a malignancy. A 66-year old woman, presenting for bone assessment, was incidentally detected with a large multinodular goitre. The left lobe has multiple nodules including TIRADS4 conglomerate. A 43-year-old woman, with bilateral mammary cysts, normal TSH, CASE SERIES

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Differentiated thyroid cancer in patients with prolactinoma

Cited by 2 publications

References 0 publications

Nodular Thyroid Disease and Papillary Thyroid Carcinoma in Functional Pituitary Adenomas

Nodular Thyroid Disease and Papillary Thyroid Carcinoma in Functional Pituitary Adenomas

Thyroid nodules: a puzzle in gynaecological endocrinology

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