Differentiated thyroid cancer in children: diagnosis and management

Abstract

The optimal treatment of differentiated thyroid cancer in pediatric patients continues to be debated. Recent publications from institutions around the world provide useful data regarding current approaches to this unusual disease. Further collaborative studies are needed to further refine the surgical approach, particularly the extent of lymph-node dissection, radioactive iodine dosing, and the role of genetic analysis in diagnosis and clinical approach.

Surgical management of well-differentiated thyroid carcinoma in children and adolescents: 33 years of experience of a single institution in Serbia

“…There are no published randomized prospective therapeutic trials yet [11,14,[24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Surgery of thyroid carcinoma in children varies among institutions regarding the surgery on thyroid gland and the lymph nodes.…”

Evaluation and Management of Pediatric Thyroid Nodules

“…As a consequence, Japanese clinicians may see an increase in the number of pediatric thyroid cancers in the next three to ten years. These cancers are exclusively of the papillary subtype, have different RET/PTC rearrangements, and behave somewhat differently than sporadic tumors (Demidchik et al, 2006;Dinauer et al, 2008;Pacini, 2002). …”

“…The prevalence of palpable thyroid nodules in patients less than 21 years of age is only .05-1.8% (American Cancer Society [ACS], 2009;Dinauer & Francis, 2007;Dinauer et al, 2008;Gosepath et al, 2007;Halac & Zimmerman, 2005, Niedziela, 2006Ortel & Klinck 1965;Rallison et al 1991;Wartofsky, 2000;Wiersinga, 2007). However, the true incidence of incidental nodules may be higher than 13% in the pediatric and adolescent group based on autopsy studies.…”

Ultrasound Elastography - Review of Techniques and Its Clinical Applications in Pediatrics - Part 2

“…However, even 25% of these nodules are malignant [13,15]. Fine-needle aspiration cytology (FNAC) is the main tool to define the character of the nodule due to its high accuracy and Picture of Tsukuba 4 lymph node during maximum tissue compression.…”