Differentiated thyroid cancer: Impact of adjuvant external radiotherapy in patients with perithyroidal tumor infiltration (stage pT4)

Farahati, Jamshid; Reiners, Christoph; Stuschke, Martin; Müller, Stefan; Stüben, Georg; Sauerwein, W.; Sack, H.

doi:10.1002/(sici)1097-0142(19960101)77:1<172::aid-cncr28>3.0.co;2-1

Cited by 200 publications

(103 citation statements)

References 27 publications

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“…In 1996, however, a further retrospective analysis was published containing 99 irradiated and 70 non-irradiated patients with stage pT4, pN0-1 tumors diagnosed according to uniform criteria (i. e. UICC 1987). This study showed a statistically significant survival advantage for irradiated patients over 40 years of age with papillary carcinoma and lymph node involvement [7]. In our study patients with pT4 tumors showed a trend towards better survival (87% vs 46%) with postoperative irradiation than without; this did not reach statistical significance (p = 0.06).…”

Section: External Radiotherapy: Pro and Contracontrasting

confidence: 70%

“…This is in accordance with the data of the present study, with 10-year survival rates of 92%. These high survival rates involve a further problem: Even though the frequency of local recurrence can be decreased by irradiation [7,20,30], this does not necessarily translate into a significant further prolongation of survival.…”

Section: External Radiotherapy: Pro and Contramentioning

confidence: 99%

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Differentiated Thyroid Cancer: Prognostic Factors and Influence of Treatment on the Outcome in 441 Patients

Sautter-Bihl¹,

Raub²,

Hetzel-Sesterheim³

et al. 2001

Strahlenther Onkol

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Section: External Radiotherapy: Pro and Contracontrasting

confidence: 70%

Section: External Radiotherapy: Pro and Contramentioning

confidence: 99%

Differentiated Thyroid Cancer: Prognostic Factors and Influence of Treatment on the Outcome in 441 Patients

Sautter-Bihl¹,

Raub²,

Hetzel-Sesterheim³

et al. 2001

Strahlenther Onkol

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“…External radiotherapy is effective in local disease control and prevention of locoregional recurrence for patients with papillary carcinoma. [25][26][27] We have previously shown that external radiotherapy achieves local control in 81% of patients when residual microscopic disease is present and achieves complete regression in 37% of patients with macroscopic disease. 27 Radiotherapy also is effective in the palliation of patients with distressing local symptoms.…”

Section: Discussionmentioning

confidence: 99%

Long‐term results in elderly patients with differentiated thyroid carcinoma

Vini

Hyer

Marshall

et al. 2003

Cancer

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BACKGROUNDThe authors assessed the biologic behavior of differentiated thyroid carcinoma in patients age 70 years or older and evaluated factors that influenced long‐term survival.METHODSAmong 1448 patients with differentiated thyroid carcinoma who were treated at the authors' institution over the past 60 years, 111 patients were identified who were age 70 years or older at the time of their initial diagnosis (range, 70–93 years). The authors conducted a retrospective analysis of the outcome of these 111 patients, who had a median follow‐up of 9 years (range, 2–9 years).RESULTSThere were 83 female patients and 28 male patients (female to male ratio, 3:1). Fifty‐eight tumors were papillary, 46 tumors were follicular, and 7 tumors were Hürthle cell carcinoma. Eighty percent of patients presented with a thyroid mass, and 70% of tumors were pathologic stage T3 (pT3) or pT4. Lymph node disease was evident at presentation in 44% of patients, and distant metastases were documented at diagnosis in 23% of patients. Forty‐six patients underwent total thyroidectomy, and the remaining patients underwent subtotal thyroidectomy or biopsy only. Radioiodine was administered to 80 patients, and external beam radiotherapy was administered to 19 patients. The cause specific survival rates were 75%, 50%, and 50% at 5 years, 10 years, and 15 years, respectively. Multivariate analysis showed that the presence of metastases was the most important independent prognostic factor for survival. External beam radiotherapy was associated with a poorer prognosis, in that it was reserved for patients with either inoperable disease or residual disease after surgery and patients with no uptake of radioiodine.CONCLUSIONSA large proportion of thyroid tumors showed extrathyroid spread and distant metastases, which frequently were not iodine‐avid. The prevalent histologic type was papillary, often with features of poor differentiation. Thyroid carcinoma in the elderly appears to behave more aggressively, and they have a less favorable prognosis compared with younger adults. Cancer 2003;97:2736–42. © 2003 American Cancer Society.DOI 10.1002/cncr.11410

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“…The standard treatment for locally advanced DTC is surgical resection, radioiodine therapy, and suppression of thyroid-stimulating hormone (TSH) [10,15]. In some retrospective analyses, additional adjuvant radiotherapy was associated with improved local control or survival in these patients [7,12,27]. There has been no randomized trial so far that tested the use of radiotherapy in DTC.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Adjuvant Radiotherapy in Locally Advanced Differentiated Thyroid Carcinoma

et al. 2003

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Differentiated thyroid cancer: Impact of adjuvant external radiotherapy in patients with perithyroidal tumor infiltration (stage pT4)

Abstract: In addition to total thyroidectomy, treatment with radioiodine, and TSH-suppressive therapy with thyroid hormone, adjuvant external radiotherapy improves the recurrence-free survival in patients older than age 40 years with invasive PTC and lymph node involvement.

Cited by 200 publications

References 27 publications

Differentiated Thyroid Cancer: Prognostic Factors and Influence of Treatment on the Outcome in 441 Patients

Differentiated Thyroid Cancer: Prognostic Factors and Influence of Treatment on the Outcome in 441 Patients

Long‐term results in elderly patients with differentiated thyroid carcinoma

Acute Toxicity of Adjuvant Radiotherapy in Locally Advanced Differentiated Thyroid Carcinoma

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