Background: Differentiated service delivery model such as Community Drug Distribution Points (CDDPs) was adopted by Uganda as one of the strategies to decongest the HIV clinics as well as decentralizing HIV care services closer to the stable clients with undetectable viral load. Despite the creation of CDDPs in the catchment areas of accredited anti-retroviral therapy clinics, its utilization remains low at 25%. However, there is little information on the barriers and facilitators to the utilization of CDDPs among adolescents aged 10 to19 years living with HIV in Uganda. The aim of this study was to explore the barriers and facilitators to utilization of CDDPs among Adolescent Living With HIV (ALWHIV) aged 10-19 years in Lira District, Northern Uganda.Methods: We conducted an exploratory descriptive study. A total of 29 qualitative interviews were conducted. Participants were purposively selected. Categories of participants included adolescents aged 10 to19 years living with HIV, caregivers of minors, and lay health care workers at the selected CDDPs. Data was collected using in-depth interviews, focus group discussions and key informant interviews. Data was audio recorded, transcribed and coded manually in which the codes were agreed upon by the authors of the study. The coded data was summarized into major themes on a matrix using master sheet analysis technique. Thematic content analysis was done, the findings were narrated verbatim and presented as text quotes.Results: Our data shows a number of barriers to utilization of CDDPs among ALWHIV in rural settings. Barriers were categorized as individual level (limited level of privacy, fears and worries, long waiting hours and distance), family related (insults and heavy work load) and health system related (lack of transport). Major facilitators to utilization of CDDPs included ease of access to ART care services, shorter waiting time, desires to remain healthy and productive, and peer support and group encouragement. Conclusion and recommendations: Our study adds important public health evidence that CDDPs, as one of the community-based models, seems to be serving underprivileged population with low level of education. We recommend provision of appropriate infrastructures used as CDDPs to protect clients’ privacy and confidentiality. ALWHIV need to be served as individuals on arrival as members of the groups at the CDDPs. There is need to strengthen community engagement and sensitization to eliminate HIV related stigma experienced by ALWHIV.